2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdultBody CompositionBody Mass IndexDiabetes Mellitus, Type 2FemaleGlucoseHumansMaleNative Hawaiian or Other Pacific IslanderObesityConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesA stop-gain variant in BTNL9 is associated with atherogenic lipid profiles
Carlson J, Krishnan M, Rosenthal S, Russell E, Zhang J, Hawley N, Moors J, Cheng H, Dalbeth N, de Zoysa J, Watson H, Qasim M, Murphy R, Naseri T, Reupena M, Viali S, Stamp L, Tuitele J, Kershaw E, Deka R, McGarvey S, Merriman T, Weeks D, Minster R. A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles. Human Genetics And Genomics Advances 2022, 4: 100155. PMID: 36340932, PMCID: PMC9630829, DOI: 10.1016/j.xhgg.2022.100155.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtherosclerosisButyrophilinsCholesterol, HDLDyslipidemiasHumansNative Hawaiian or Other Pacific IslanderTriglyceridesConceptsStop-gain variantUnique population historyFine-mapping analysisEuropean ancestry populationsGenetic architecturePolynesian populationsPopulation historyGenetic analysisAssociation studiesSuggestive associationPolynesian ancestryCurrent understandingEvidence of associationAmerican SamoaBiological foundationsVariantsGeneticsPopulationNew ZealandBTNL9AncestryPregnancy health and perinatal outcomes among Pacific Islander women in the United States and US Affiliated Pacific Islands: Protocol for a scoping review
Suss R, Mahoney M, Arslanian KJ, Nyhan K, Hawley NL. Pregnancy health and perinatal outcomes among Pacific Islander women in the United States and US Affiliated Pacific Islands: Protocol for a scoping review. PLOS ONE 2022, 17: e0262010. PMID: 35041684, PMCID: PMC8765672, DOI: 10.1371/journal.pone.0262010.Peer-Reviewed Original ResearchAsianFemaleHawaiiHumansNative Hawaiian or Other Pacific IslanderPregnancyPregnancy OutcomeUnited States
2021
Preterm birth among Pacific Islander women and related perinatal outcomes: a scoping review protocol
Wu B, Arslanian KJ, Nyhan K, Taylor S, Shabanova V, Muasau-Howard B, Hawley NL. Preterm birth among Pacific Islander women and related perinatal outcomes: a scoping review protocol. BMJ Open 2021, 11: e050483. PMID: 34728448, PMCID: PMC8565552, DOI: 10.1136/bmjopen-2021-050483.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolFemaleHumansInfant, NewbornMinority GroupsNative Hawaiian or Other Pacific IslanderPeer ReviewPregnancyPremature BirthResearch DesignReview Literature as TopicSystematic Reviews as TopicConceptsPreterm birthPacific IslandersMaternal-child health outcomesCause of deathPreferred Reporting ItemsJoanna Briggs Institute ManualPacific Islander womenFull-text screeningPerinatal outcomesFuture study designsPeer-reviewed journalsCochrane LibraryRisk factorsEligible studiesConsensus reviewReporting ItemsHealth outcomesReview protocolEvidence mappingStudy designEvidence synthesisBirthOutcomesScoping ReviewMinority populations
2020
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian KJ, Fidow UT, Atanoa T, Unasa-Apelu F, Naseri T, Wetzel AI, Pomer A, Duckham RL, McGarvey ST, Strayer JA, Kershaw EE, Weeks DE, Hawley NL. A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants. International Journal Of Obesity 2020, 45: 45-55. PMID: 32884101, PMCID: PMC8329753, DOI: 10.1038/s41366-020-00659-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody CompositionCross-Sectional StudiesFemaleGenotypeHumansInfantInfant, NewbornMaleMutation, MissenseNative Hawaiian or Other Pacific IslanderPolymorphism, Single NucleotideProspective StudiesSamoaTumor Suppressor ProteinsYoung AdultConceptsBody mass indexDual-energy X-ray absorptiometrySamoan infantsBone massFat massLean massEarly infantsBody compositionInfant body mass indexMinor alleleDeterminants of adiposityOdds of diabetesBone mass accretionMissense variantsX-ray absorptiometryFat-free massCross-sectional analysisMore bone massCREBRF variantProspective studyHigher oddsEarly infancyInfantsAdult populationNatural history