The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesThe missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans
Fu H, Hawley NL, Carlson JC, Russell EM, Pomer A, Cheng H, Naseri T, Reupena M, Deka R, Choy CC, McGarvey ST, Minster RL, Weeks DE. The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans. Obesity Research & Clinical Practice 2022, 16: 220-227. PMID: 35606300, PMCID: PMC9373717, DOI: 10.1016/j.orcp.2022.04.004.Peer-Reviewed Original ResearchConceptsBMI rateHousehold asset scoreAA genotypeBody mass indexMissense variantsBMI of femalesSex-stratified modelsHigh rateAG participantsBaseline BMIMean BMICohort studyMass indexSamoan adultsPhysical activityGG genotypeBMIAge groupsA alleleLongitudinal changesAsset scoreRs373863828Older participantsFemalesCREBRF