2022
Why is leptospirosis hard to avoid for the impoverished? Deconstructing leptospirosis transmission risk and the drivers of knowledge, attitudes, and practices in a disadvantaged community in Salvador, Brazil
Palma F, Costa F, Lustosa R, Mogaji H, de Oliveira D, Souza F, Reis M, Ko A, Begon M, Khalil H. Why is leptospirosis hard to avoid for the impoverished? Deconstructing leptospirosis transmission risk and the drivers of knowledge, attitudes, and practices in a disadvantaged community in Salvador, Brazil. PLOS Global Public Health 2022, 2: e0000408. PMID: 36962720, PMCID: PMC10022107, DOI: 10.1371/journal.pgph.0000408.Peer-Reviewed Original ResearchLow socioeconomic statusLower riskLeptospirosis transmissionSocioeconomic statusIndividual infection riskEnvironmental risk factorsPublic health messagingUrban disadvantaged communitiesKAP variablesMale genderRisk factorsCross-sectional KAP surveyEpidemiological dataHigh-risk activitiesHealth messagingPrevention practicesGreater riskInfection riskInfectious diseasesKAP surveyTransmission riskResidents' knowledgeDisadvantaged communitiesRiskRisk activitiesStructural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey
Fofana MO, Nery N, Ticona J, de Andrade Belitardo EMM, Victoriano R, Anjos RO, Portilho MM, de Santana MC, dos Santos LL, de Oliveira D, Cruz JS, Muenker MC, Khouri R, Wunder EA, Hitchings MDT, Johnson O, Reis MG, Ribeiro GS, Cummings DAT, Costa F, Ko AI. Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey. PLOS Medicine 2022, 19: e1004093. PMID: 36074784, PMCID: PMC9499230, DOI: 10.1371/journal.pmed.1004093.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSARS-CoV-2 infection riskUrban slumsSyndrome coronavirus 2 infectionSARS-CoV-2 seroprevalenceSARS-CoV-2 incidenceCoronavirus 2 infectionCross-sectional serosurveyMain outcome measuresUrban slum populationPresence of IgGSARS-CoV-2 spike proteinUrban slum communityCross-sectional surveyUrban slum residentsCumulative incidenceMedian ageRisk factorsOutcome measuresStudy populationHigh seroprevalenceMedian dailyPandemic waveGender distributionBiannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil
Cruz J, Nery N, Sacramento G, Victoriano R, Montenegro A, Santana J, Costa F, Ko A, Reis M, Wunder E. Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil. Frontiers In Medicine 2022, 9: 862378. PMID: 35492362, PMCID: PMC9048256, DOI: 10.3389/fmed.2022.862378.Peer-Reviewed Original ResearchMicroscopic agglutination testAntibody kineticsEndemic areasReinfection eventsSubcohort of individualsBurden of leptospirosisLife-threatening diseaseProspective cohortClinical manifestationsAsymptomatic infectionHumoral responseRisk factorsImmune responseLeptospirosis infectionAgglutination testPaucity of informationSerological surveyLeptospirosisSample collection timeInfectionLeptospira interrogansSubcohortFurther studiesHigh rateDisease
2021
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Silva M, Kikuti M, Anjos R, Portilho M, Santos V, Gonçalves T, Tauro L, Moreira P, Jacob-Nascimento L, Santana P, Campos G, Siqueira A, Kitron U, Reis M, Ribeiro G. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal Of Infectious Diseases 2021, 105: 608-616. PMID: 33684559, DOI: 10.1016/j.ijid.2021.03.003.Peer-Reviewed Original ResearchConceptsChronic arthralgiaChikungunya virus infectionRisk factorsVirus infectionDaily activitiesAcute febrile illnessIndependent risk factorPersistence of painCohort of patientsImpact of painProgression of diseaseTranscriptase-polymerase chain reactionPersistent arthralgiaFebrile illnessSubstantial disabilityViral loadFemale sexPolymerase chain reactionIgM enzymeArthralgiaSurveillance studyChikungunya virusDengue virusPatientsImmunosorbent assay
2019
Bloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features
Leal H, Azevedo J, Silva G, Amorim A, de Roma L, Arraes A, Gouveia E, Reis M, Mendes A, de Oliveira Silva M, Barberino M, Martins I, Reis J. Bloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features. BMC Infectious Diseases 2019, 19: 609. PMID: 31296179, PMCID: PMC6624930, DOI: 10.1186/s12879-019-4265-z.Peer-Reviewed Original ResearchConceptsK. pneumoniaePrevious antimicrobial useLaboratory-based surveillanceAntimicrobial susceptibility testingMDR bacteremiaMDR-GNBDrug-resistant pathogensNegative bacteremiaLiver diseaseBloodstream infectionsHigh morbidityMale sexRisk factorsEpidemiological aspectsNegative bacilliHealthcare professionalsMicrobiological featuresSusceptibility testingBacteremiaInfectionAntimicrobial useCausative agentAntibiotic resistanceIntervention measuresResistance determinants
2016
Factors affecting carriage and intensity of infection of Calodium hepaticum within Norway rats (Rattus norvegicus) from an urban slum environment in Salvador, Brazil
WALKER R, CARVALHO-PEREIRA T, SERRANO S, PEDRA G, HACKER K, TAYLOR J, MINTER A, PERTILE A, PANTI-MAY A, CARVALHO M, SOUZA FN, NERY N, RODRIGUES G, BAHIENSE T, REIS MG, KO AI, CHILDS JE, BEGON M, COSTA F. Factors affecting carriage and intensity of infection of Calodium hepaticum within Norway rats (Rattus norvegicus) from an urban slum environment in Salvador, Brazil. Epidemiology And Infection 2016, 145: 334-338. PMID: 27780498, PMCID: PMC6247895, DOI: 10.1017/s0950268816002259.Peer-Reviewed Original ResearchConceptsIntensity of infectionNorway ratsIndependent risk factorC. hepaticumHumans of exposureUrban slum environmentsCalodium hepaticumUrban slum areaSlum areasLiver involvementMammalian hostsRisk factorsInfective eggsRatsCarriage levelsSignificant riskInfectionUrban slumsCarriageFurther studiesSub-standard living conditionsRiskZoonotic pathogensSlum environmentRodent-borne zoonotic pathogens
2009
Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Machado A, Finkmoore B, Emodi K, Takenami I, Barbosa T, Tavares M, Reis M, Arruda S, Riley L. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 719-25. PMID: 19460247.Peer-Reviewed Original ResearchConceptsHousehold contactsLatent tuberculosis infectionLTBI treatmentLatent tuberculosis infection treatmentTB-endemic countriesRisks of treatmentHigh-risk populationPulmonary TBMedication intoleranceTuberculosis infectionTuberculosis controlRisk factorsHigh riskSide effectsInfection treatmentHospitalVisitsMonthsTreatmentFollowINHRiskTBRegimenPatients
2008
Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza C, Barbosa C, de Moura Neto J, Barreto J, Reis M, Gonçalves M. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics And Molecular Biology 2008, 31: 39-41. DOI: 10.1590/s1415-47572008000100008.Peer-Reviewed Original ResearchChronic myeloid leukemiaAcute promyelocytic leukemiaRisk factorsMyeloid leukemiaTypes of leukemiaGlutathione S-transferase thetaGSTT1null genotypeAPL patientsGSTM1 polymorphismHealthy controlsBrazilian patientsPromyelocytic leukemiaNull genotypeControl groupGene polymorphismsGSTT1 genesLeukemiaPatientsMultiplex PCRPolymorphismDifferent populationsAssociation studiesGroup
2002
Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic.
Sarkar U, Nascimento S, Barbosa R, Martins R, Nuevo H, Kalofonos I, Kalafanos I, Grunstein I, Flannery B, Dias J, Riley L, Reis M, Ko A. Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic. American Journal Of Tropical Medicine And Hygiene 2002, 66: 605-10. PMID: 12201599, DOI: 10.4269/ajtmh.2002.66.605.Peer-Reviewed Original ResearchConceptsRisk factorsUrban epidemicPopulation-based case-control studyPopulation-based case-control investigationIndependent risk factorLaboratory-confirmed casesHealthy neighbourhood controlsCase-control investigationCase-control studyCases of leptospirosisSevere leptospirosisWeil's syndromeWorkplace exposuresNeighborhood controlsHigh endemicityLeptospirosisFocused interventionsMore ratsSyndromeRatsEpidemicEnvironmental sourcesComplicationsFactorsMortality
1999
Urban epidemic of severe leptospirosis in Brazil
Ko A, Reis M, Dourado C, Johnson W, Riley L, Group S. Urban epidemic of severe leptospirosis in Brazil. The Lancet 1999, 354: 820-825. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.Peer-Reviewed Original ResearchConceptsDengue feverInfectious disease referral hospitalAggressive supportive careEpidemic of leptospirosisStrong independent predictorPositive blood culturesLarge urban outbreaksIdentification of leptospiresRenal insufficiencyRespiratory insufficiencySevere leptospirosisSupportive careIndependent predictorsReferral hospitalOutpatient clinicSevere anemiaSevere manifestationsActive surveillanceMental statusRisk factorsBlood culturesDiagnostic confusionUrban epidemicMicroagglutination testUrban outbreaks