2025
A streamlined CRISPR-based test for tuberculosis detection directly from sputum
Bell A, Dunkley O, Modi N, Huang Y, Tseng S, Reiss R, Daivaa N, Davis J, Vargas D, Banada P, Xie Y, Myhrvold C. A streamlined CRISPR-based test for tuberculosis detection directly from sputum. Science Advances 2025, 11: eadx2067. PMID: 40768573, PMCID: PMC12327463, DOI: 10.1126/sciadv.adx2067.Peer-Reviewed Original ResearchMeSH KeywordsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsHumansMycobacterium tuberculosisNucleic Acid Amplification TechniquesSensitivity and SpecificitySputumTuberculosis
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunity Health CentersFemaleHIV InfectionsHumansMaleMiddle AgedModels, StatisticalMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesPoint-of-Care TestingTime-to-TreatmentTuberculosisUgandaConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosis
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