2023
A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samples
2022
Is aggregated surveillance data a reliable method for constructing tuberculosis care cascades? A secondary data analysis from Uganda
White E, Hernández-Ramírez R, Majwala R, Nalugwa T, Reza T, Cattamanchi A, Katamba A, Davis J. Is aggregated surveillance data a reliable method for constructing tuberculosis care cascades? A secondary data analysis from Uganda. PLOS Global Public Health 2022, 2: e0000716. PMID: 36962541, PMCID: PMC10045605, DOI: 10.1371/journal.pgph.0000716.Peer-Reviewed Original ResearchNational TB ProgrammeTreatment initiationAntiretroviral therapySurveillance dataLimits of agreementFacility characteristicsTB surveillance dataTuberculosis care cascadeNumber of peopleXpert-positivesCare cascadeTB careTB treatmentTB programsTuberculosis controlQuality improvement toolsSecondary data analysisHealth facilitiesPositive diagnosisAddress reasonsLinear mixed modelsConcordance correlation coefficientHIVTherapyDiagnosis
2015
Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis
Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. The Journal Of Infectious Diseases 2015, 212: 990-998. PMID: 25762787, PMCID: PMC4548467, DOI: 10.1093/infdis/jiv149.Peer-Reviewed Original ResearchConceptsDrug-tolerant bacilliDrug exposureDrug-susceptible pulmonary tuberculosisDrug-tolerant Mycobacterium tuberculosisDrug-susceptible Mycobacterium tuberculosisMycobacterium tuberculosisTuberculosis treatment regimensInitial drug exposureReverse transcription-polymerase chain reactionMessenger RNA expressionM. tuberculosis gene expressionDrug efflux pumpsSerial sputaPulmonary tuberculosisTreatment initiationNovel drug targetsTreatment regimensPolymerase chain reactionToxin-antitoxin genesHuman tuberculosisRate of declineDrug responsivenessStress signatureMarked downregulationDrug tolerance