2024
Cardiomyopathy‐Associated Chronic Heart Failure in Infants Aged <1 Year: A Prospective Observational Cohort Over 5 Years in Northern China
Ding W, Wang B, Hong J, Lu L, Xiao Y, Shan G, Myers C, Yu Q, Spurney C, Li Z, Han L. Cardiomyopathy‐Associated Chronic Heart Failure in Infants Aged <1 Year: A Prospective Observational Cohort Over 5 Years in Northern China. Journal Of The American Heart Association 2024, 13: e029121. PMID: 39344650, PMCID: PMC11681489, DOI: 10.1161/jaha.122.029121.Peer-Reviewed Original ResearchConceptsBundle-branch blockHeart failureVentricular noncompactionReduced left ventricular ejection fractionInfants aged <1 yearPatients up to 5Infants aged <1Pediatric heart centersOutcomes of infantsPresence of left bundle-branch blockVentricular ejection fractionLeft ventricular noncompactionEjection fraction groupChronic heart failureProspective observational studyYear of diagnosisChinese pediatric populationSecondary to cardiomyopathyProspective observational cohortIncreased heart sizeFavorable predictorsBaseline LVEFEjection fractionNo significant differenceMedical therapy
2013
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y. The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs. Molecular Cell 2013, 52: 101-112. PMID: 24055342, PMCID: PMC3843377, DOI: 10.1016/j.molcel.2013.08.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationComputational BiologyDatabases, GeneticGene Expression ProfilingGene Expression RegulationGenomic ImprintingGenotypeHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansMiceMicroRNAsMuscle DevelopmentMyoblasts, SkeletalPhenotypeRibonucleoproteinsRNA InterferenceRNA, Long NoncodingTime FactorsTransfectionConceptsLet-7 familyWide transcriptome analysisHuman genetic disordersNoncanonical binding siteLet-7 microRNALet-7 overexpressionGene functionH19 depletionTranscriptome analysisMuscle differentiationMolecular spongeUnexpected modeImportant regulatorAdult muscleH19 knockdownRecent implicationMiR-675Physiological significanceMicroRNAsH19Binding sitesGenetic disordersOverexpressionImportant roleFetal tissues
2012
High lead exposure is associated with telomere length shortening in Chinese battery manufacturing plant workers
Wu Y, Liu Y, Ni N, Bao B, Zhang C, Lu L. High lead exposure is associated with telomere length shortening in Chinese battery manufacturing plant workers. Occupational And Environmental Medicine 2012, 69: 557. PMID: 22539657, DOI: 10.1136/oemed-2011-100478.Peer-Reviewed Original ResearchConceptsLead exposurePlant workersLong-term lead exposureBody mass indexHigh lead exposureBattery plant workersTelomere length shorteningWeak positive associationInpatient workersMass indexAge-associated diseasesInverse associationBurden assessmentStrong inverse correlationMultivariate analysisOccupational pollutantsLength shorteningLead levelsInverse correlationTelomere lengthLead toxicityBLLPositive associationPublic healthQuantitative PCR
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply