2025
Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study
Oliveira C, Shapiro E, Sheth S, Ellingson M, Johnson N, Sullivan E, Querec T, Unger E, Niccolai L. Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study. The Lancet Regional Health - Americas 2025, 51: 101225. PMID: 41019517, PMCID: PMC12465035, DOI: 10.1016/j.lana.2025.101225.Peer-Reviewed Original ResearchHPV vaccinationCase-control studyHuman papillomavirusVaccine effectivenessClinical effectsDose of HPV vaccineHigh-grade cervical lesionsOdds ratioBenefits of HPV vaccinationEffectiveness of HPV vaccinationMultivariable conditional logistic regression modelsVaccine-eligible womenPap smear resultsHuman papillomavirus vaccineConfidence intervalsConditional logistic regression modelsCenters for Disease Control and PreventionDisease Control and PreventionCervical lesionsSmear resultsFirst doseHPV-16Pap testControl and PreventionLogistic regression modelsEpidemiologic, Clinical, and economic Burden of AnoGenital Warts Among Adults: A Global Systematic Review
You X, Valente S, Machalek D, Felsher M, Pieniazek I, Nowicka K, Tota J, Chen Y, Niccolai L, Cui F. Epidemiologic, Clinical, and economic Burden of AnoGenital Warts Among Adults: A Global Systematic Review. International Journal Of Infectious Diseases 2025, 108029. PMID: 40882763, DOI: 10.1016/j.ijid.2025.108029.Peer-Reviewed Original ResearchAnogenital wartsHuman papillomavirusManifestations of human papillomavirusEconomic burdenHuman papillomavirus vaccination programsSystematic reviewEvidence-Based Medicine ReviewsClinical impactIncidence rateEpidemiological dataGlobal systematic reviewGlobal surveillanceHigh-income countriesVaccination programMedicine ReviewsWartsAgeConference proceedingsEvidence-basedIncidenceIncome levelSexBurdenReviewPapillomavirusInfluence of Community-Level Factors on Health Care Provider Recommendations for HPV Vaccine
Ellingson M, O’Leary S, Schwartz J, Niccolai L. Influence of Community-Level Factors on Health Care Provider Recommendations for HPV Vaccine. Pediatrics Open Science 2025, 1: 1-9. DOI: 10.1542/pedsos.2024-000263.Peer-Reviewed Original ResearchCommunity-level factorsHealth care providersHealth care provider recommendationHuman papillomavirus vaccineHuman papillomavirusInfluence of community-level factorsNon-White adolescentsZip codesNational Immunization Survey-TeenHuman papillomavirus vaccine coverageHigh-poverty zip codesRate of unemploymentAssociated with higher population densityCommunity-level educationUS Census Bureau dataAge-eligible patientsCare provider recommendationEvidence-based interventionsCensus Bureau dataPoverty statusLogistic regression analysisAdolescent raceStatistically significant interactionCare providersSurvey-TeenEstimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus
Xu H, Aparicio C, Wats A, Araujo B, Pitzer V, Warren J, Shapiro E, Niccolai L, Weinberger D, Oliveira C. Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus. JAMA Network Open 2025, 8: e250380. PMID: 40063022, PMCID: PMC11894488, DOI: 10.1001/jamanetworkopen.2025.0380.Peer-Reviewed Original ResearchConceptsRSV-positive casesCase-control studyRSV infectionLRTI-associated hospitalizationsWeeks postimmunizationLong-acting monoclonal antibodiesTest-negative case-control studyClinical settingRespiratory syncytial virusMultivariate logistic regressionYale New Haven Health SystemRSV diseaseEmergency department dataState immunization registryRSV seasonSyncytial virusNirsevimabPolymerase chain reactionClinical trialsLRTIInfantsPotential confoundersMonoclonal antibodiesBroader outcomesDisease severity
2024
U.S. Women with Invasive Cervical Cancer: Characteristics and Potential Barriers to Prevention
Rosenblum H, Gargano J, Cleveland A, Dahl R, Park I, Whitney E, Castilho J, Sackey E, Niccolai L, Brackney M, Debess E, Ehlers S, Bennett N, Kurtz R, Unger E, Markowitz L. U.S. Women with Invasive Cervical Cancer: Characteristics and Potential Barriers to Prevention. Journal Of Women's Health 2024, 33: 594-603. PMID: 38608239, PMCID: PMC11995403, DOI: 10.1089/jwh.2023.0462.Peer-Reviewed Original ResearchInvasive cervical cancerEvaluate characteristics of womenPopulation-based descriptive studyInvasive cervical cancer diagnosisCervical cancer screeningReduce cervical cancer ratesPopulation-based surveillance sitesCervical cancer ratesIdentified potential barriersNon-white womenAdvent of screeningPotential barriersCharacteristics of womenIncident invasive cervical cancerCancer screeningPreventive careCancer ratesCervical cancerMental illnessSubstance use disordersChi-square testDescriptive frequenciesDescriptive studyMultiple barriersSurveillance sites
2023
Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019
Sheth S, Johnson N, Sullivan E, Torres A, Oliveira C, Niccolai L. Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019. Journal Of Women's Health 2023, 33: 28-32. PMID: 37943625, PMCID: PMC10794823, DOI: 10.1089/jwh.2022.0456.Peer-Reviewed Original ResearchConceptsMid-adult womenVaccination statusHPV vaccinationHPV vaccineHuman Papillomavirus Vaccination StatusHPV vaccination statusHuman papillomavirus vaccinationAge 26 yearsHealth care providersCross-sectional surveyPapillomavirus vaccinationUnvaccinated womenVaccinated womenVaccine informationCare providersVaccinationAdult womenVaccineWomenBehavioral correlatesCorrelatesStatusPotential benefitsYearsParticipantsHuman papillomavirus vaccine effectiveness by age at vaccination: A systematic review
Ellingson M, Sheikha H, Nyhan K, Oliveira C, Niccolai L. Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review. Human Vaccines & Immunotherapeutics 2023, 19: 2239085. PMID: 37529935, PMCID: PMC10399474, DOI: 10.1080/21645515.2023.2239085.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSystematic reviewHuman Papillomavirus Vaccine EffectivenessVaccine-type HPV infectionYounger ageHigh vaccine effectivenessHuman papillomavirus vaccineVaccine effectiveness studiesYounger age groupsAdolescents ages 15Adolescents ages 9HPV infectionHPV vaccineVaccine initiationPapillomavirus vaccineTime vaccinationAnogenital wartsCervical abnormalitiesCervical cancerDisease outcomeAge groupsOlder ageEffectiveness studiesAge 15AgeAcceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA
Nawrocki C, Piedmonte N, Niesobecki S, Rowe A, Hansen A, Kaufman A, Foster E, Meek J, Niccolai L, White J, Backenson B, Eisen L, Hook S, Connally N, Hornbostel V, Hinckley A. Acceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA. Ticks And Tick-borne Diseases 2023, 14: 102231. PMID: 37531890, PMCID: PMC10883357, DOI: 10.1016/j.ttbdis.2023.102231.Peer-Reviewed Original ResearchFailure to Complete Multidose Vaccine Series in Early Childhood.
Michels S, Niccolai L, Hadler J, Freeman R, Albers A, Glanz J, Daley M, Newcomer S. Failure to Complete Multidose Vaccine Series in Early Childhood. 2023, 152 PMID: 37489285, PMCID: PMC10389773, DOI: 10.1542/peds.2022-059844.Peer-Reviewed Original ResearchConceptsVaccine seriesVaccination patternsUS childrenAdditional vaccine doseEarly childhood immunizationVaccine dosePreventable diseaseChildhood immunizationSeries completionNumber of childrenSociodemographic factorsInsurance coverageStrong associationOptimal protectionEarly childhoodBinomial regressionChildrenDosesAssociationStructural barriersCoverage goalsVaccinationImmunizationA review of data systems for assessing the impact of HPV vaccination in selected high-income countries
Wang W, Kothari S, Khoury H, Niccolai L, Garland S, Sundström K, de Pouvourville G, Bonanni P, Chen Y, Franco E. A review of data systems for assessing the impact of HPV vaccination in selected high-income countries. Expert Review Of Vaccines 2023, 22: 161-179. PMID: 36576068, DOI: 10.1080/14760584.2023.2162505.Peer-Reviewed Original ResearchConceptsHigh-income countriesHPV vaccinationCervical cancer prevention policyCharacteristics of HPVHuman papillomavirus vaccinationCervical screening programmeEarly detection measuresCancer prevention policiesWorld Health OrganizationPapillomavirus vaccinationCervical cancerVaccination coverageDisease outcomeScreening programElimination effortsGlobal eliminationPrevention programsTreatment programData SystemVaccinationHealth OrganizationHPVTargeted reviewPrevention policiesUnited StatesClinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review
King L, Lewnard J, Niccolai L. Clinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review. Open Forum Infectious Diseases 2023, 10: ofad004. PMID: 36726535, PMCID: PMC9887268, DOI: 10.1093/ofid/ofad004.Peer-Reviewed Original ResearchHPV vaccinationHuman papillomavirusNarrative reviewHPV natural historyRecurrent respiratory papillomatosisPublic health considerationsRespiratory papillomatosisOropharyngeal cancerAnogenital wartsPrevious infectionCancer casesUS guidelinesVaccinationImportant causeNatural historyAvailable evidenceSexual behaviorPatientsHealth considerationsCancerCliniciansBroad implementationGreater awarenessWide variationPapillomatosis
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original ResearchMessaging of Different Disease Outcomes for Human Papillomavirus Vaccination: A Systematic Review
Niccolai L, Johnson N, Torres A, Sullivan E, Hansen C. Messaging of Different Disease Outcomes for Human Papillomavirus Vaccination: A Systematic Review. Journal Of Adolescent Health 2022, 72: 334-343. PMID: 36529616, DOI: 10.1016/j.jadohealth.2022.10.018.Peer-Reviewed Original Research
2021
“The Squeaky Wheel Gets the Grease”: Rental Assistance Applicants’ Quests for a Rationed and Scarce Resource
Keene D, Rosenberg A, Schlesinger P, Whittaker S, Niccolai L, Blankenship K. “The Squeaky Wheel Gets the Grease”: Rental Assistance Applicants’ Quests for a Rationed and Scarce Resource. Social Problems 2021, 70: 203-218. PMID: 36798516, PMCID: PMC9928171, DOI: 10.1093/socpro/spab035.Peer-Reviewed Original Research
2020
A Multi Region Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States
Johnson N, Warren J, Elliott E, Niccolai L, Deziel N. A Multi Region Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1089.Peer-Reviewed Original ResearchPhysician and patient prediction of adherence to antiretroviral therapy in HIV positive people in Saint-Petersburg, Russia
Vetrova M, Aleksandrova O, Paschenko A, Toropov S, Rassokhin V, Abyshev R, Levina O, Niccolai L, Heimer R. Physician and patient prediction of adherence to antiretroviral therapy in HIV positive people in Saint-Petersburg, Russia. AIDS Care 2020, 33: 473-477. PMID: 32148065, DOI: 10.1080/09540121.2020.1738005.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV-positive peopleART initiationPositive peopleHIV viral suppressionPatient predictionsAccuracy of providerReview of pharmacyART retentionHIV physiciansViral suppressionPhysicians' predictionsTreatment outcomesART outcomesPatientsAdherenceLaboratory dataTherapyLongitudinal analysisOutcomesProvidersInitiationPhysiciansCare
2019
Introduction to Immunology, Epidemiology, and Immunoepidemiology
Niccolai L, Ruddle N, Krause P. Introduction to Immunology, Epidemiology, and Immunoepidemiology. 2019, 3-17. DOI: 10.1007/978-3-030-25553-4_1.ChaptersIndividual multicellular organismsImmune responseMulticellular organismsRelevant health problemHealth-related eventsInflammatory diseasesSelect populationCombination of cellsHealth problemsEpidemiologic toolImmunoepidemiologyMicrobial infectionsEpidemiologyGenetic polymorphismsImmunologyEnvironmental factorsPopulationAutoimmunityMalignancyOrganismsInfectionDiversityDiseaseStudy962. Trends in Cervical Pre-cancers by Race and Ethnicity During the Human Papillomavirus Vaccine Era, HPV Vaccine Impact Monitoring Project (HPV-IMPACT), United States, 2008–2016
Gargano J, Lewis R, Hunt H, McClung N, Bennett N, Griffin M, Niccolai L, Park I, Powell M, Brackney M, Scahill M, Pemmaraju M, Fink D, Ehlers S, Cleveland A, Unger E, Markowitz L. 962. Trends in Cervical Pre-cancers by Race and Ethnicity During the Human Papillomavirus Vaccine Era, HPV Vaccine Impact Monitoring Project (HPV-IMPACT), United States, 2008–2016. Open Forum Infectious Diseases 2019, 6: s29-s29. PMCID: PMC6809029, DOI: 10.1093/ofid/ofz359.064.Peer-Reviewed Original ResearchAverage annual percentage changeCervical intraepithelial neoplasiaRace/ethnicityVaccine eraYear oldsNH blacksNH whitesHuman papillomavirus vaccine introductionActive population-based surveillanceHPV vaccine eraPopulation-based surveillanceConfidence intervalsAnnual percentage changeSignificant declineScreened womenVaccine impactRace/ethnicity dataCervical cancerIntraepithelial neoplasiaVaccine introductionCIN2Hispanic womenJoinpoint softwareSitu casesAge groupsP836 Trends in anogenital warts since introduction of human papillomavirus vaccines in connecticut, USA
Niccolai L, Brackney M. P836 Trends in anogenital warts since introduction of human papillomavirus vaccines in connecticut, USA. Sexually Transmitted Infections 2019, 95: a351. DOI: 10.1136/sextrans-2019-sti.881.Peer-Reviewed Original ResearchO17.5 Declining trends in anogenital warts since HPV vaccine introduction in a large urban health system, 2013–2017
Yakely A, Oliviera C, Niccolai L. O17.5 Declining trends in anogenital warts since HPV vaccine introduction in a large urban health system, 2013–2017. Sexually Transmitted Infections 2019, 95: a79. DOI: 10.1136/sextrans-2019-sti.203.Peer-Reviewed Original ResearchIncident anogenital wartsAnogenital wartsHPV vaccineVaccine impactBirth cohortImportant public health priorityLarge urban health systemElectronic medical record dataHPV vaccine impactTrends of HPVHPV vaccine introductionNumber of patientsPublic health priorityMedical record dataSignificant declineProportion of visitsUrban health systemBirth cohort analysisCochran-Armitage testEarlier birth cohortsLater birth cohortsMale vaccinationGenital wartsRoutine vaccinationRoutine recommendation
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