2025
Design of field trials for the evaluation of transmissible vaccines in animal populations
Sheen J, Kennedy-Shaffer L, Levy M, Metcalf C. Design of field trials for the evaluation of transmissible vaccines in animal populations. PLOS Computational Biology 2025, 21: e1012779. PMID: 39899630, PMCID: PMC11790233, DOI: 10.1371/journal.pcbi.1012779.Peer-Reviewed Original ResearchReview: "The health and employment effects of employer vaccination mandates"
Kennedy-Shaffer L. Review: "The health and employment effects of employer vaccination mandates". Rapid Reviews: Infectious Diseases January 2025. DOI:10.1162/2e3983f5.6cd00cbf.Commentaries, Editorials and Letters
2024
Review 2: “Parallel trends in an unparalleled pandemic: difference-in- differences for infectious disease policy evaluation.”
Kennedy-Shaffer L. Review 2: “Parallel trends in an unparalleled pandemic: difference-in-differences for infectious disease policy evaluation.” Rapid Reviews: Infectious Diseases May 2024. DOI:10.1162/2e3983f5.7efdeb76.Commentaries, Editorials and LettersProbably Overthinking It
Kennedy-Shaffer L. Probably Overthinking It. The Mathematical Intelligencer 2024, 46: 403-405. DOI: 10.1007/s00283-024-10349-y.Commentaries, Editorials and LettersQuasi-experimental methods for pharmacoepidemiology: difference-in-differences and synthetic control methods with case studies for vaccine evaluation
Kennedy-Shaffer L. Quasi-experimental methods for pharmacoepidemiology: difference-in-differences and synthetic control methods with case studies for vaccine evaluation. American Journal Of Epidemiology 2024, 193: 1050-1058. PMID: 38456774, PMCID: PMC11228849, DOI: 10.1093/aje/kwae019.Peer-Reviewed Original ResearchConceptsSynthetic control methodDifference-in-differencesHealth policyCase studyAverage treatment effectQuasi-experimental methodPolicyQuasi-experimental designWeight assumptionPopulation-level effectsTime trendsStudy designSources of evidenceConfounding factorsEvaluation studiesPharmacoepidemiologyTarget estimandAbsence of contamination
2023
Supporting the Use of Institutional Data to Improve Outcomes
Feingold P, Kennedy-Shaffer L, Wee J, Jaklitsch M, Marshall M. Supporting the Use of Institutional Data to Improve Outcomes. The Annals Of Thoracic Surgery 2023, 117: 875-876. PMID: 37827350, DOI: 10.1016/j.athoracsur.2023.09.045.Commentaries, Editorials and LettersTeaching the Difficult Past of Statistics to Improve the Future
Kennedy-Shaffer L. Teaching the Difficult Past of Statistics to Improve the Future. Journal Of Statistics And Data Science Education 2023, 32: 108-119. DOI: 10.1080/26939169.2023.2224407.Peer-Reviewed Original ResearchAnastomotic Stricture After Minimally Invasive Esophagectomy
Feingold P, Bryan D, Kuckelman J, Kennedy-Shaffer L, Wang V, Deeb A, Wee J, Jaklitsch M, Marshall M. Anastomotic Stricture After Minimally Invasive Esophagectomy. The Annals Of Thoracic Surgery 2023, 116: 712-719. PMID: 37244601, DOI: 10.1016/j.athoracsur.2023.05.013.Peer-Reviewed Original ResearchConceptsMinimally invasive esophagectomyInvasive esophagectomyAnastomotic strictureMinimally invasive esophagectomy approachesUnivariate analysis of patientsSingle-institution retrospective reviewAssociated with strictureAnalysis of patientsProportion of patientsDay of surgeryPercentage of patientsAssociated with anastomotic strictureTumor histologyTumor stageAnastomotic dilatationInitial dilationSurgeon variablesUnivariate analysisMultivariate analysisPrimary outcomeEsophagectomyStricturePatientsRisk factorsImprove outcomesReview of: “Measuring the efficacy of a vaccine during an epidemic.”
Kennedy-Shaffer L. Review of: “Measuring the efficacy of a vaccine during an epidemic.” Qeios May 2023. DOI:10.32388/VZ07WE.Commentaries, Editorials and LettersPublic Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials.
Kennedy-Shaffer L. Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials. American Journal Of Public Health 2023, 113: 778-785. PMID: 37104734, PMCID: PMC10262256, DOI: 10.2105/ajph.2023.307302.Peer-Reviewed Original ResearchConceptsPublic health impactCOVID-19 pandemicPopulation healthEvidence baseCOVID-19Health impactsInfectious disease outbreaksCommunity levelRandomized trialsIndividual levelRegulatory barriersPivotal trialsClinical benefitTrialsClinical trialsVaccine trialsPrevent infectionStrategic deploymentVaccineHealthComparative performance of between-population vaccine allocation strategies with applications for emerging pandemics
Joshi K, Rumpler E, Kennedy-Shaffer L, Bosan R, Lipsitch M. Comparative performance of between-population vaccine allocation strategies with applications for emerging pandemics. Vaccine 2023, 41: 1864-1874. PMID: 36697312, PMCID: PMC10075509, DOI: 10.1016/j.vaccine.2022.12.053.Peer-Reviewed Original Research
2022
Baseball's Natural Experiment
Kennedy-Shaffer L. Baseball's Natural Experiment. Significance 2022, 19: 42-45. DOI: 10.1111/1740-9713.01691.Peer-Reviewed Original ResearchReviewer Report: “Characterising the persistence of RT-PCR positivity and incidence in a community survey of SARS-CoV-2.”
Kennedy-Shaffer L. Reviewer Report: “Characterising the persistence of RT-PCR positivity and incidence in a community survey of SARS-CoV-2.” Wellcome Open Research August 2022. DOI:10.21956/wellcomeopenres.19611.r52063.Commentaries, Editorials and LettersViral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection
Kennedy-Shaffer L. Review 1: “Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection.” Rapid Reviews: COVID-19 May 2022. DOI:10.1162/2e3983f5.80a2172a.Commentaries, Editorials and LettersThe required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings
Sheen J, Haushofer J, Metcalf C, Kennedy‐Shaffer L. The required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings. Statistics In Medicine 2022, 41: 2466-2482. PMID: 35257398, PMCID: PMC9111156, DOI: 10.1002/sim.9365.Peer-Reviewed Original ResearchConceptsCluster randomized trialEffectiveness of interventionsSample sizeRandomized trialsPlanning such trialsApproximate sample size formulaeReduce transmissionEffect sizeNonpharmaceutical interventionsInfectious disease outbreaksObservational studyInterventionEpidemic settingsSample size methodsAdequate powerSARS-CoV-2 pandemicSARS-CoV-2 transmissionSample size formulaTested individualsSimulated bankTreatment effectsTrialsCommunity transmissionOutbreak settingsSize formulaRapid Response: Assumption of independence between LFT results and infectiousness, given PCR results, may not hold
Kennedy-Shaffer L. Rapid Response: Assumption of independence between LFT results and infectiousness, given PCR results, may not hold. Rapid Response to BMJ 2022;376:e066871. BMJ March 2022. https://www.bmj.com/content/376/bmj-2021-066871/rr-1.Commentaries, Editorials and Letters
2021
Power and sample size calculations for cluster randomized trials with binary outcomes when intracluster correlation coefficients vary by treatment arm
Kennedy-Shaffer L, Hughes M. Power and sample size calculations for cluster randomized trials with binary outcomes when intracluster correlation coefficients vary by treatment arm. Clinical Trials 2021, 19: 42-51. PMID: 34879711, PMCID: PMC8883478, DOI: 10.1177/17407745211059845.Peer-Reviewed Original ResearchConceptsWorking correlation structureIntracluster correlation coefficientIntracluster correlation coefficient valuesAsymptotic varianceCorrelation structureClustered binary dataSample size requirementsSample size calculationCluster-level covariatesExchangeable working correlation structureCluster randomized trialModest-sized clustersBinary covariateSize calculationBinary outcomesBinary dataDistribution of cluster sizesFormulaCluster size distributionSize requirementsCovariatesEquationsSample sizeCluster sizeRandomized trialsEstimating Vaccine Efficacy Against Transmission via Effect on Viral Load
Kennedy-Shaffer L, Kahn R, Lipsitch M. Estimating Vaccine Efficacy Against Transmission via Effect on Viral Load. Epidemiology 2021, 32: 820-828. PMID: 34469363, PMCID: PMC8478108, DOI: 10.1097/ede.0000000000001415.Peer-Reviewed Original ResearchConceptsViral load measurementsVaccine efficacyViral loadMeasure of vaccine efficacyRandomized controlled trialsEstimates of vaccine efficacyVirological testingAsymptomatic infectionVaccine effectivenessSevere diseaseControlled trialsViral variantsSARS-CoV-2Estimate efficacyEfficacySARS-CoV-2 pandemicVaccineLoad measurementsInfectionVirus transmissionJoint Estimation of Generation Time and Incubation Period for Coronavirus Disease 2019
Lau Y, Tsang T, Kennedy-Shaffer L, Kahn R, Lau E, Chen D, Wong J, Ali T, Wu P, Cowling B. Joint Estimation of Generation Time and Incubation Period for Coronavirus Disease 2019. The Journal Of Infectious Diseases 2021, 224: 1664-1671. PMID: 34423821, PMCID: PMC8499762, DOI: 10.1093/infdis/jiab424.Peer-Reviewed Original ResearchEstimating epidemiologic dynamics from cross-sectional viral load distributions
Hay J, Kennedy-Shaffer L, Kanjilal S, Lennon N, Gabriel S, Lipsitch M, Mina M. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science 2021, 373: eabh0635. PMID: 34083451, PMCID: PMC8527857, DOI: 10.1126/science.abh0635.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply