The required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings
Sheen J, Haushofer J, Metcalf C, Kennedy‐Shaffer L. The required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings. Statistics In Medicine 2022, 41: 2466-2482. PMID: 35257398, PMCID: PMC9111156, DOI: 10.1002/sim.9365.Peer-Reviewed Original ResearchConceptsCluster randomized trialEffectiveness of interventionsSample sizeRandomized trialsPlanning such trialsApproximate sample size formulaeReduce transmissionEffect sizeNonpharmaceutical interventionsInfectious disease outbreaksObservational studyInterventionEpidemic settingsSample size methodsAdequate powerSARS-CoV-2 pandemicSARS-CoV-2 transmissionSample size formulaTested individualsSimulated bankTreatment effectsTrialsCommunity transmissionOutbreak settingsSize formulaStatistical Properties of Stepped Wedge Cluster-Randomized Trials in Infectious Disease Outbreaks
Kennedy-Shaffer L, Lipsitch M. Statistical Properties of Stepped Wedge Cluster-Randomized Trials in Infectious Disease Outbreaks. American Journal Of Epidemiology 2020, 189: 1324-1332. PMID: 32648891, PMCID: PMC7604531, DOI: 10.1093/aje/kwaa141.Peer-Reviewed Original ResearchConceptsWedge trialsParallel-arm cluster-randomized trialsStepped wedge cluster randomized trialStatistical propertiesCluster randomized trialStatistical disadvantageStepped wedge trialIndividual randomizationInfectious disease outbreaksCluster randomized designEvaluation of interventionsEvaluate various designsTrial designDetect intervention effectsWedge designRandomized controlled trialsIntervention effectsEffect estimatesControlled trialsParallel-armEpidemic settingsLogistical factorsAdequate powerInfectious disease incidenceRandomized trials