2025
Obtaining population-based estimates for survey data using Bayesian hierarchical models with Poststratification
Zhang Y, Gill T, Bandeen-Roche K, Becher R, Davis-Plourde K, Zang E. Obtaining population-based estimates for survey data using Bayesian hierarchical models with Poststratification. American Journal Of Epidemiology 2025, kwaf209. PMID: 40977048, DOI: 10.1093/aje/kwaf209.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyPopulation-based estimatesEstimates of frailtyBayesian estimationBayesian hierarchical modelPrevalence estimatesSample weightSample sizeBayesian approachLarge-scale surveyHierarchical modelSurvey dataTrends StudyBayesian modelEstimationPoststratificationCohortFrailtyCombined cohortComparing Disaster‐Related Surge Staffing Practices Across Rural and Non‐Rural Nursing Homes
Festa N, Alexovitz K, Davis‐Plourde K, Marottoli R, Cohen A, Dosa D, Fulmer T, Gill T. Comparing Disaster‐Related Surge Staffing Practices Across Rural and Non‐Rural Nursing Homes. Journal Of The American Geriatrics Society 2025 PMID: 40938301, DOI: 10.1111/jgs.70098.Peer-Reviewed Original ResearchCenters for Medicare & Medicaid ServicesRural facilitiesNursing homesStaffing intensityLicensed nurse staffingInterrupted time series designConfidence intervalsStaff representationTime series designNurse staffingStaffing approachStaffing differencesLinear probability modelsRetrospective cohort studyMedicaid ServicesLinear mixed-effects modelsNon-ruralSeries designStaffing changesWorkforce conditionsCohort studyMixed-effects modelsStaffingRoutine staffStaffing strategiesLosses to Follow‐Up in a Nationally Representative Study of Community‐Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes
Gill T, Liang J, Becher R, Davis‐Plourde K. Losses to Follow‐Up in a Nationally Representative Study of Community‐Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes. Journal Of The American Geriatrics Society 2025 PMID: 40928486, DOI: 10.1111/jgs.70093.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyNationally Representative StudyMedicare dataIncomplete ascertainmentIncidence rate ratiosAscertainment of mortalityAll-Cause MortalityTrends StudyOlder AmericansRate ratiosMortality outcomesMedicareParticipantsCohortInterviewsMortalitySensitive filesNondecedentsPotential trade-offsEvaluating the Applicability of Federal Regulatory Metrics for Nursing Home Fire Safety and Emergency Preparedness
Festa N, Alexovitz K, Throgmorton K, Davis-Plourde K, Dosa D, Gill T. Evaluating the Applicability of Federal Regulatory Metrics for Nursing Home Fire Safety and Emergency Preparedness. Journal Of The American Medical Directors Association 2025, 26: 105828. PMID: 40882948, DOI: 10.1016/j.jamda.2025.105828.Peer-Reviewed Original ResearchCorrigendum to “Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality” [Health Place 92 (2025) 103438]
Wang Y, Zang E, Davis-Plourde K, Gill T, Becher R. Corrigendum to “Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality” [Health Place 92 (2025) 103438]. Health & Place 2025, 95: 103486. PMID: 40683782, DOI: 10.1016/j.healthplace.2025.103486.Peer-Reviewed Original ResearchPeer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial
Nath B, Desai R, Cook J, Dziura J, Davis-Plourde K, Youins R, Guy K, Pavlo A, Smith E, Smith D, Kangas K, Heckmann R, Hart L, Powsner S, Sevilla M, Evans M, Kumar A, Faustino I, Hu Y, Bellamy C, Wong A. Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial. BMJ Open 2025, 15: e103775. PMID: 40484432, PMCID: PMC12161358, DOI: 10.1136/bmjopen-2025-103775.Peer-Reviewed Original ResearchConceptsCluster randomised controlled trialEmergency departmentPeer supportDelivery of trauma-informed careStepped-wedge cluster randomised controlled trialExperience of mental illnessPhysical restraintRate of physical restraintBehavioral crisesPeer support workersReduce restraint useSecondary outcomesFollow-up data collectionResponse teamPatient-centred approachPositive patient outcomesTrauma-informed carePeer-reviewed journalsCrisis response teamsUsual careStepped-wedgeIntervention readinessPeer deliveryRestraint useED settingIncidence of Frailty, Dementia, and Disability Among Community‐Living Older Americans According to County‐Level Disadvantage
Wang Y, Zang E, Davis‐Plourde K, Vander Wyk B, Gill T, Becher R. Incidence of Frailty, Dementia, and Disability Among Community‐Living Older Americans According to County‐Level Disadvantage. Journal Of The American Geriatrics Society 2025, 73: 1847-1856. PMID: 40196885, PMCID: PMC12213133, DOI: 10.1111/jgs.19465.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyActivities of daily living disabilityActivities of daily livingIncidence of frailtySocial determinants of healthOlder personsOlder AmericansContextual disadvantageAge- and sex-adjusted HRDisadvantaged countiesDeterminants of healthSex-adjusted HRNationally representative longitudinal studyRepresentative longitudinal studyCommunity-livingDaily livingClinically Meaningful OutcomesTrends StudyGeriatric conditionsNo prior studiesNational incidenceIncidence rateDementiaFrailtyCounty-levelNovel indices of state- and county-level social disadvantage in older Americans and disparities in mortality
Wang Y, Zang E, Davis-Plourde K, Gill T, Becher R. Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality. Health & Place 2025, 92: 103438. PMID: 40058245, PMCID: PMC12142587, DOI: 10.1016/j.healthplace.2025.103438.Peer-Reviewed Original ResearchConceptsIncreased mortality riskContextual disadvantageOlder personsOlder AmericansCommunity-living older personsSocial disadvantageMortality riskIndices of social disadvantageReduce health disparitiesPopulation of older AmericansCounty-levelPublic health policiesNon-disadvantaged groupsMortality disparitiesHealth disparitiesHealth policyMortality existUnited StatesDisadvantaged countiesNegative binomial modelGeriatric populationComposite indexDisparitiesDisadvantaged statesMultidimensional factorsIncomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans
Gill T, Liang J, Vander Wyk B, Leo-Summers L, Wang Y, Becher R, Davis-Plourde K. Incomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans. The Journals Of Gerontology Series A 2025, 80: glaf014. PMID: 39823281, PMCID: PMC12269764, DOI: 10.1093/gerona/glaf014.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyAscertainment of mortalityIncomplete ascertainmentLongitudinal studies of older personsStudy of older personsNationally representative longitudinal studyIncidence rate ratiosLoss to follow-upMortality incidence ratesYear of deathLongitudinal studyRepresentative longitudinal studyCommunity-livingTrends StudyOlder personsRecommended strategiesMedicare dataRate ratiosCumulative mortality rateIncidence rateResults of longitudinal analysesAscertainmentEvaluate mortalityLongitudinal analysisDecedents
2024
A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 22: 45-56. PMID: 39377196, PMCID: PMC11810615, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized Estimating EquationsPermutationMedian sample sizeIntervention conditionRandomization methodEquationsNational Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
2023
Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022
Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Tong G, Wang X, Ortiz-Reyes L, Caille A, Li F, Taljaard M. Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022. Clinical Trials 2023, 21: 199-210. PMID: 37990575, PMCID: PMC11003836, DOI: 10.1177/17407745231208397.Peer-Reviewed Original ResearchAssessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US
Festa N, Throgmorton K, Davis-Plourde K, Dosa D, Chen K, Zang E, Kelly J, Gill T. Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. JAMA Network Open 2023, 6: e2320207. PMID: 37358851, PMCID: PMC10293909, DOI: 10.1001/jamanetworkopen.2023.20207.Peer-Reviewed Original ResearchConceptsCross-sectional studyNursing homesNursing home characteristicsMean survival timeUS nursing homesGreater mean numberPrimary outcomeUS CentersExposure statusMAIN OUTCOMEElevated riskSurvival timeSurvival analysisPresence of deficienciesMore deficienciesRisk statusEmergency preparednessHome characteristicsMean numberRiskPreparedness standardsDeficiencyResponsivenessHigh percentageOutcomesA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReporting
2022
Power analyses for stepped wedge designs with multivariate continuous outcomes
Davis‐Plourde K, Taljaard M, Li F. Power analyses for stepped wedge designs with multivariate continuous outcomes. Statistics In Medicine 2022, 42: 559-578. PMID: 36565050, PMCID: PMC9985483, DOI: 10.1002/sim.9632.Peer-Reviewed Original ResearchConceptsMultivariate outcomesMultivariate linear mixed modelIntracluster correlation coefficientSample size proceduresClosed cohort designRigorous justificationSample size calculation procedureTreatment effect estimatorJoint distributionSize proceduresTest statisticLinear mixed modelsEfficient treatment effect estimatorsCommon treatment effectMixed modelsCalculation procedureExtensive simulationsEffects estimatorIntersection-union testPower analysisEstimatorWedge designEfficient powerModelContinuous outcomesNon-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study
Weinstein G, O’Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study. Journal Of Alzheimer’s Disease 2022, 86: 1371-1383. PMID: 35213373, PMCID: PMC11323287, DOI: 10.3233/jad-215409.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePrevalent non-alcoholic fatty liver diseaseFIB-4 indexFatty liver diseaseAlzheimer's disease pathologyFIB-4Liver fibrosisDisease pathologyAdvanced fibrosisLiver diseaseTau pathologyRisk factorsRelationship of NAFLDTau positron emission tomography (PET) imagingEarly Alzheimer's disease pathologyCardio-metabolic risk factorsAlcoholic fatty liver diseaseThird Generation cohortsFramingham Study participantsNon-invasive indexPositron emission tomography (PET) imagingEmission Tomography ImagingMiddle-aged adultsRegional tauLiver steatosisJoint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias
Davis-Plourde KL, Mayeda ER, Lodi S, Filshtein T, Beiser A, Gross AL, Seshadri S, Glymour MM, Tripodis Y. Joint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias. Epidemiology 2022, 33: 362-371. PMID: 35383644, DOI: 10.1097/ede.0000000000001472.Peer-Reviewed Original ResearchConceptsCognitive declineSurvival biasCox proportional hazards modelHazard of mortalityProportional hazards modelExposure of interestEffect of educationEffects of exposureHazards modelDementia diagnosisAlzheimer's diseaseMixed-effects modelsGEE modelMortalitySurvivalInconsistent resultsDiseaseInformative attritionStudy dataAttrition weightsExposure
2021
Sample Size Considerations for Stepped Wedge Designs with Subclusters
Davis-Plourde K, Taljaard M, Li F. Sample Size Considerations for Stepped Wedge Designs with Subclusters. Biometrics 2021, 79: 98-112. PMID: 34719017, PMCID: PMC9054939, DOI: 10.1111/biom.13596.Peer-Reviewed Original ResearchCoronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffnessAutonomic Imbalance and Risk of Dementia and Stroke
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke. Stroke 2021, 52: 2068-2076. PMID: 33874747, PMCID: PMC8154675, DOI: 10.1161/strokeaha.120.030601.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAutonomic imbalanceHeart rateDementia riskRate variabilityStroke riskNormal intervalsCardiac autonomic imbalanceLower heart rate variabilityLower stroke riskCommunity-based cohortRisk of dementiaSuccessive differencesAutonomic nervous systemNormal RR intervalsOlder-aged adultsExam 7Incident strokeDementia pathophysiologyIncident dementiaPotential confoundersStroke occurrenceDementia incidenceThird examinationNervous system
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