2025
Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort
Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.Peer-Reviewed Original ResearchConceptsRisk of dementiaParametric g-formulaUK Biobank cohortG-formulaBiobank cohortLate lifeFree of dementiaUK Biobank participantsModifiable risk factorsParticulate matterAerodynamic diameter <Annual average standardBiobank participantsHypothetical interventionAmbient particulate matterNo interventionDementiaRisk differenceInterventionRisk factorsHealth benefitsPotential health benefitsCohortRiskParticipantsFloods and cause-specific mortality in the United States applying a triply robust approach
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States applying a triply robust approach. Nature Communications 2025, 16: 2853. PMID: 40122917, PMCID: PMC11930965, DOI: 10.1038/s41467-025-58236-0.Peer-Reviewed Original ResearchConceptsCDC's National Center for Health StatisticsNational Center for Health StatisticsCause-specific mortality ratesCenter for Health StatisticsCause-specific mortalityHealth impacts of floodingExcess all-cause deathsLong-term health risksFlood daysLong-term associationDeath recordsHealth StatisticsConfounder adjustmentExternal causesStorm Events DatabaseAll-cause deathHealth impactsImpact of floodsPropensity scorePost‐flood yearMortality rateMyocardial infarctionPost-floodContiguous U.S.Respiratory disease
2019
Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014
Chen K, Breitner S, Wolf K, Hampel R, Meisinger C, Heier M, von Scheidt W, Kuch B, Peters A, Schneider A, Peters A, Schulz H, Schwettmann L, Leidl R, Heier M, Strauch K. Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014. European Heart Journal 2019, 40: 1600-1608. PMID: 30859207, DOI: 10.1093/eurheartj/ehz116.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI riskCases of MIRisk of MITime-stratified case-crossover analysisPopulation susceptibilityCase-crossover analysisArea of AugsburgCoronary deathDiabetes mellitusNon-significant declineSubgroup analysisRelative riskLag non-linear modelShort-term exposureMI eventsEnvironmental triggersInfarctionRiskFuture studiesSocioeconomic settingsAssociationExposureSusceptibility
2018
Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study
Chen K, Fiore AM, Chen R, Jiang L, Jones B, Schneider A, Peters A, Bi J, Kan H, Kinney PL. Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study. PLOS Medicine 2018, 15: e1002598. PMID: 29969446, PMCID: PMC6029756, DOI: 10.1371/journal.pmed.1002598.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAir PollutantsCardiovascular DiseasesCause of DeathChildChild, PreschoolChinaClimate ChangeEnvironmental MonitoringFemaleHealth StatusHumansInfantInfant, NewbornInhalation ExposureMaleMiddle AgedModels, TheoreticalOzonePopulation DynamicsPrognosisRespiratory Tract DiseasesRisk AssessmentRisk FactorsSeasonsTime FactorsUrban HealthVehicle EmissionsYoung AdultConceptsGlobal chemistry-climate modelChemistry-climate modelOzone-related mortalityRepresentative Concentration PathwaysEmission scenariosHigh global warmingGlobal warmingClimate changeChange scenariosOzone pollutionClimate Change (IPCC) Representative Concentration PathwaysEmission scenario RCP8.5Emission scenarios RCP4.5Future ozone projectionsStatistical downscaling approachModerate global warmingOzone precursor emissionsFine spatial resolutionSpatial resolutionHigh ambient ozoneOzone projectionsOzone changesOzone observationsScenario RCP8.5Change projections
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