2025
Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort
Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.Peer-Reviewed Original ResearchConceptsRisk of dementiaParametric g-formulaUK Biobank cohortG-formulaBiobank cohortLate lifeFree of dementiaUK Biobank participantsModifiable risk factorsParticulate matterAerodynamic diameter <Annual average standardBiobank participantsHypothetical interventionAmbient particulate matterNo interventionDementiaRisk differenceInterventionRisk factorsHealth benefitsPotential health benefitsCohortRiskParticipantsEffect of Air Pollution Reductions on Mortality During the COVID-19 Lockdowns in Early 2020.
Chen K, Ma Y, Marb A, Nobile F, Dubrow R, Stafoggia M, Breitner S, Kinney P. Effect of Air Pollution Reductions on Mortality During the COVID-19 Lockdowns in Early 2020. Research Report 2025, 2025: 1-47. PMID: 40551404, PMCID: PMC12185919.Peer-Reviewed Original ResearchConceptsAir pollution changesAir pollutionPollution changesShort-term exposure to PM<sub>2.5</sub>Air qualityExposure to PM<sub>2.5</sub>Natural-causeMeteorological normalization techniqueFine particulate matterDaily air pollutionImprove air qualityAir pollutant emissionsAir pollution reductionEmission control strategiesSouthern ItalyQuantify changesAir pollution-mortality relationshipPollution-mortality relationshipCOVID-19 lockdownShort-term exposureNOParticulate matterMeteorological impactsNitrogen dioxidePollution reduction
2024
Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsAir PollutionEnvironmental ExposureFemaleHumansMaleMortalityParticulate MatterSmokeUnited StatesWildfiresConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PM<sWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesShort-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries
Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney P, Chen K. Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. JAMA Network Open 2024, 7: e2354607. PMID: 38427355, PMCID: PMC10907920, DOI: 10.1001/jamanetworkopen.2023.54607.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsCross-Sectional StudiesEnvironmental ExposureFemaleHumansNitrogen DioxideParticulate MatterConceptsShort-term exposure to air pollutionExposure to air pollutionFine particulate matterCross-sectional studyAir pollutionFixed-effects modelParticulate matterShort-term exposure to PM2.5Short-term exposure to fine particulate matterNO2 concentrationsExposure to fine particulate matterMortality rateNitrogen dioxideSignificant effect modificationDaily PM2.5 concentrationsTime-varying confoundersExposure to PM2.5Health outcomesEstimate associationsMortality dataEffect modificationPM2.5 concentrationsMain OutcomesDay-to-dayCentral-southern Italy
2023
Associations between short-term exposure to PM2.5, NO2 and O3 pollution and kidney-related conditions and the role of temperature-adjustment specification: A case-crossover study in New York state
Chu L, Chen K, Di Q, Crowley S, Dubrow R. Associations between short-term exposure to PM2.5, NO2 and O3 pollution and kidney-related conditions and the role of temperature-adjustment specification: A case-crossover study in New York state. Environmental Pollution 2023, 328: 121629. PMID: 37054868, DOI: 10.1016/j.envpol.2023.121629.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCross-Over StudiesEnvironmental ExposureHumansKidneyKidney DiseasesNew YorkNitrogen DioxideParticulate MatterTemperature
2020
Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany
Chen K, Schneider A, Cyrys J, Wolf K, Meisinger C, Heier M, von Scheidt W, Kuch B, Pitz M, Peters A, Breitner S, Group F. Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany. Environmental Health Perspectives 2020, 128: 017003. PMID: 31939685, PMCID: PMC7015564, DOI: 10.1289/ehp5478.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionEnvironmental ExposureGermanyHumansMyocardial InfarctionParticulate MatterConceptsMyocardial infarctionMI casesTime-stratified case-crossover analysisConditional logistic regressionInterquartile range increaseCase-crossover analysisTwo-pollutant modelsMI registryEpidemiological evidenceDifferent particle metricsCardiovascular diseaseMyocardial infractionSimilar associationLogistic regressionHourly air pollutionParticle metricsEffect estimatesHealth effectsExposure metricsIndependent effectsTransient exposureInfarctionAssociationExposureAerodynamic diameter
2019
Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014
Chen K, Breitner S, Wolf K, Hampel R, Meisinger C, Heier M, von Scheidt W, Kuch B, Peters A, Schneider A, Peters A, Schulz H, Schwettmann L, Leidl R, Heier M, Strauch K. Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014. European Heart Journal 2019, 40: 1600-1608. PMID: 30859207, DOI: 10.1093/eurheartj/ehz116.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedEnvironmental ExposureFemaleGermanyHot TemperatureHumansMaleMiddle AgedMyocardial InfarctionTime FactorsConceptsMyocardial infarctionMI riskCases of MIRisk of MITime-stratified case-crossover analysisPopulation susceptibilityCase-crossover analysisArea of AugsburgCoronary deathDiabetes mellitusNon-significant declineSubgroup analysisRelative riskLag non-linear modelShort-term exposureMI eventsEnvironmental triggersInfarctionRiskFuture studiesSocioeconomic settingsAssociationExposureSusceptibility
2014
Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China
Chen K, Bi J, Chen J, Chen X, Huang L, Zhou L. Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China. The Science Of The Total Environment 2014, 506: 18-25. PMID: 25460935, DOI: 10.1016/j.scitotenv.2014.10.092.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAir PollutionCardiovascular DiseasesChinaEnvironmental ExposureFemaleHot TemperatureHumansMaleMortalityRespiratory Tract DiseasesConceptsDifferent heat wave definitionsDisease mortalityChronic obstructive pulmonary disease (COPD) mortalityIschemic heart disease mortalityLag day 2Heart disease mortalityBurden of diseaseCause-specific mortalityDaily mortalityCardiovascular mortalityStroke mortalityEffect modificationHeat wave definitionsStratified analysisRespiratory mortalityDay 2Total mortalityMortalityConsecutive daysHeat warning systemsLower educationDaysAssociationGood model fitCritical role
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