2025
Quantifying disruptions to tuberculosis case detection in Brazilian states during the COVID-19 pandemic
Chitwood M, Menzies N, Bartholomay P, Pelissari D, de Barros Silva Júnior J, Harada L, Johansen F, Maciel E, Castro M, Sanchez M, Warren J, Cohen T. Quantifying disruptions to tuberculosis case detection in Brazilian states during the COVID-19 pandemic. International Journal Of Epidemiology 2025, 54: dyaf146. PMID: 40838691, DOI: 10.1093/ije/dyaf146.Peer-Reviewed Original ResearchConceptsPre-pandemic levelsTB casesCase detectionCOVID-19 pandemicBrazilian healthcare systemTB notification ratesTB case detectionHealth system disruptionsTuberculosis case detectionCase detection rateMortality dataHealthcare systemIncident TBMeta-regression frameworkTB incidenceNotification ratesSymptomatic TBCase notificationCOVID-19TB controlTB diagnosisBrazilian statesPandemicCareIndividualsPaternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study. Environmental Health 2025, 24: 48. PMID: 40652244, PMCID: PMC12255010, DOI: 10.1186/s12940-025-01199-y.Peer-Reviewed Original ResearchConceptsShort birth lengthAdverse birth outcomesBirth outcomesBirth lengthMulti-country cohort studyAntenatal care visitsAssociated with lower offspring birth weightParent-specific effectsPFAS exposureMaternal exposureBirth weightQuantile g-computationOffspring birth weightPrenatal PFAS exposureCare visitsResultsNo associationEffects of PFAS exposureG-computationLow birth weightCohort studyINUENDO cohortEffect sizeMedical recordsMethodsThis studyPaternal exposurePerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedPaternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study. Environmental Science And Technology 2025, 59: 5973-5982. PMID: 40104843, DOI: 10.1021/acs.est.4c13040.Peer-Reviewed Original ResearchConceptsBehavioral difficultiesAssociated with internalizing difficultiesStrengths and Difficulties QuestionnaireChildren's behavioral difficultiesSex-specific mannerSex-specific cut-offsExternalizing difficultiesMaternal PFASWeeks of gestationParent-rated Strengths and Difficulties QuestionnairePrenatal PFAS exposurePaternal exposurePolyfluoroalkyl substancesDifficulties QuestionnaireChild sexOffspring neurodevelopmentAssociated with behavioral difficultiesPrenatal exposureAntenatal clinicMaternal prenatal exposureINUENDO cohortAged 5Maternal exposurePerfluorononanoic acidDevelopmental toxicityRace, wealth and health: The role of reparations
Whittaker S, Hyacinthe M, Keene D, Dulin A, Kershaw T, Warren J. Race, wealth and health: The role of reparations. Social Science & Medicine 2025, 373: 117963. PMID: 40168833, PMCID: PMC12147558, DOI: 10.1016/j.socscimed.2025.117963.Peer-Reviewed Original ResearchConceptsRacial health gapsGeneral healthHealth gapPredictors of self-rated healthReport adverse health outcomesPredictors of general healthSelf-rated healthBlack respondentsExcellent/very good healthAssociated with healthMulti-level regression modelsAdverse health outcomesJustice interventionsReparation paymentsNational Longitudinal Survey of Youth 1979Dismantle systems of oppressionHealth outcomesHealth variablesPhysical healthMental healthAssess raceNational Longitudinal SurveyRacial wealth gapSystems of oppressionHealth measuresEstimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus
Xu H, Aparicio C, Wats A, Araujo B, Pitzer V, Warren J, Shapiro E, Niccolai L, Weinberger D, Oliveira C. Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus. JAMA Network Open 2025, 8: e250380. PMID: 40063022, PMCID: PMC11894488, DOI: 10.1001/jamanetworkopen.2025.0380.Peer-Reviewed Original ResearchConceptsRSV-positive casesCase-control studyRSV infectionLRTI-associated hospitalizationsWeeks postimmunizationLong-acting monoclonal antibodiesTest-negative case-control studyClinical settingRespiratory syncytial virusMultivariate logistic regressionYale New Haven Health SystemRSV diseaseEmergency department dataState immunization registryRSV seasonSyncytial virusNirsevimabPolymerase chain reactionClinical trialsLRTIInfantsPotential confoundersMonoclonal antibodiesBroader outcomesDisease severityLong-term drought and risk of infant mortality in Africa: A cross-sectional study
Wang P, Rogne T, Warren J, Asare E, Akum R, Toure N, Ross J, Chen K. Long-term drought and risk of infant mortality in Africa: A cross-sectional study. PLOS Medicine 2025, 22: e1004516. PMID: 39888958, PMCID: PMC11785314, DOI: 10.1371/journal.pmed.1004516.Peer-Reviewed Original ResearchConceptsRisk of infant mortalityInfant mortality riskCross-sectional studyInfant mortalityMortality riskIncreased risk of infant mortalityIncreased risk of neonatal mortalityIncreased riskRisk of neonatal mortalityHealth Surveys ProgramPost-neonatal mortalityCox regression modelsStatistically significant associationChild healthGlobal burdenNon-casesNeonatal mortalitySignificant associationImpact mortalityNon-exposureSurvival periodRegression modelsPregnancyMortalityHealthAmbient Toxic Air Contaminants in the Maternal Residential Area during Pregnancy and Cerebral Palsy in the Offspring
Zhuo H, Ritz B, Warren J, Pollitt K, Liew Z. Ambient Toxic Air Contaminants in the Maternal Residential Area during Pregnancy and Cerebral Palsy in the Offspring. Environmental Health Perspectives 2025, 133: 017008. PMID: 39853265, PMCID: PMC11758984, DOI: 10.1289/ehp14742.Peer-Reviewed Original ResearchConceptsToxic air contaminantsVolatile organic compoundsMaternal residential exposureCerebral palsyMixtures of volatile organic compoundsRisk of CPResidential exposureAir contaminationTraffic emission sourcesRisk factors of CPIncreased risk of CPRisk ratioCP casesEstimate mixture effectsResidential areasInterquartile range increaseConfidence intervalsLive singleton birthsModified Poisson regressionNegative control exposureQuantile-based g-computationFactors of CPCase-cohort studyContaminant mixturesEnvironmental risk factorsFactors associated with tuberculosis treatment initiation among bacteriologically negative individuals evaluated for tuberculosis: An individual patient data meta-analysis.
Kim S, Can M, Agizew T, Auld A, Balcells M, Bjerrum S, Dheda K, Dorman S, Esmail A, Fielding K, Garcia-Basteiro A, Hanrahan C, Kebede W, Kohli M, Luetkemeyer A, Mita C, Reeve B, Silva D, Sweeney S, Theron G, Trajman A, Vassall A, Warren J, Yotebieng M, Cohen T, Menzies N. Factors associated with tuberculosis treatment initiation among bacteriologically negative individuals evaluated for tuberculosis: An individual patient data meta-analysis. PLOS Medicine 2025, 22: e1004502. PMID: 39804959, PMCID: PMC11729971, DOI: 10.1371/journal.pmed.1004502.Peer-Reviewed Original ResearchConceptsIndividual Patient Data Meta-AnalysisPatient data meta-analysisTreatment initiationData Meta-AnalysisBacteriological test resultsTB treatmentFactors associated with treatment initiationMultiple factors influence decisionsAssociated with treatment initiationTuberculosis treatment initiationMeta-analysisNegative test resultsPositive test resultsFactors influence decisionsHIV infectionPulmonary tuberculosisSmear microscopyNight sweatsClinical examinationMale sexClinical criteriaHierarchical Bayesian logistic regressionCohort studySystematic reviewTreatment decisions
2024
Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Siddique S, Baum L, Deziel N, Kelly J, Warren J, Ma X. Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer. PLOS ONE 2024, 19: e0311540. PMID: 39471191, PMCID: PMC11521299, DOI: 10.1371/journal.pone.0311540.Peer-Reviewed Original ResearchConceptsAge-of-onset colorectal cancerEarly-onset colorectal cancerEnd Results program dataCenters for Disease Control and Prevention dataCounty-level factorsColorectal cancerHealth risk behaviorsIdentified principal componentsOdds of survivalPreventive servicesSurvival disparitiesLinear mixed modelsEOCRCChronic diseasesPreventive factorsUS countiesSalt Lake CountyCA residentsRisk behaviorsUnited StatesProgram dataCounty-levelOlder ageBayesian analytical approachYounger agePhylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC
Tobias Cudahy P, Liu P, Warren J, Sobkowiak B, Yang C, Ioerger T, Wu C, Lu P, Wang J, Chang H, Huang H, Cohen T, Lin H. Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1562-1570. PMID: 39043390, PMCID: PMC11286038, DOI: 10.3201/eid3008.240021.Peer-Reviewed Original ResearchConceptsM. kansasii lung diseaseM. kansasii pulmonary diseasePulmonary diseaseM. kansasii isolatesSputum mycobacterial cultureWhole-genome sequencingEvaluate risk factorsPhylogeographic analysisAge of participantsGenetic relatednessEnvironmental acquisitionLung diseaseMycobacterial cultureOdds ratioRisk factorsM. kansasiiPatientsDiseasePlantsEnvironmental transmissionIsolatesPark plantingsCDCRiskHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancy
2023
Season of Conception and Risk of Cerebral Palsy
Zhuo H, Ritz B, Warren J, Liew Z. Season of Conception and Risk of Cerebral Palsy. JAMA Network Open 2023, 6: e2335164. PMID: 37738049, PMCID: PMC10517373, DOI: 10.1001/jamanetworkopen.2023.35164.Peer-Reviewed Original ResearchConceptsCerebral palsySeason of conceptionCalifornia birth recordsCohort studyPreterm birthRelative riskBirth recordsRisk of CPStatewide cohort studyEtiological risk factorsHigher Social Vulnerability IndexLength of gestationDiagnostic recordsNeighborhood-level factorsSummer conceptionsRisk factorsStratified analysisLive birthsMAIN OUTCOMEHigh riskCP riskPoisson regressionCP statusDevelopmental servicesNeuromotor disabilities
2022
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 2022, 375: eabl4292. PMID: 35084937, PMCID: PMC9261115, DOI: 10.1126/science.abl4292.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Effectiveness of vaccinesEffectiveness of vaccinationTotal vaccine effectivenessSARS-CoV-2Household contactsSecond doseCoronavirus 2Household transmissionDelta variantDay 10VaccinationBNT162b2COVID-19InfectionChain binomial modelVaccineDoseImmunity
2019
Improved Detection of Visual Field Progression Using a Spatiotemporal Boundary Detection Method
Berchuck SI, Mwanza JC, Tanna AP, Budenz DL, Warren JL. Improved Detection of Visual Field Progression Using a Spatiotemporal Boundary Detection Method. Scientific Reports 2019, 9: 4642. PMID: 30874616, PMCID: PMC6420602, DOI: 10.1038/s41598-018-37127-z.Peer-Reviewed Original Research
2017
Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy
Warren JL, Son JY, Pereira G, Leaderer BP, Bell ML. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy. American Journal Of Epidemiology 2017, 187: 992-1000. PMID: 29053768, PMCID: PMC5928458, DOI: 10.1093/aje/kwx335.Peer-Reviewed Original ResearchConceptsLow birth weightTerm low birth weightMaternal residential mobilityBirth weightCritical windowBirth cohortWeekly exposurePregnancy week 16Adverse birth outcomesWindow of susceptibilityAmbient air pollutionPregnancy windowsBirth outcomesWeek 16Mother's residencePM10 exposurePregnancyResidential addressesExposure misclassificationDisease developmentCohortAir pollutionExposureAerodynamic diameterPossible mechanismSpatial Variability in the Persistence of Pneumococcal Conjugate Vaccine-targeted Pneumococcal Serotypes Among Adults
Warren JL, Pingali SC, Weinberger DM. Spatial Variability in the Persistence of Pneumococcal Conjugate Vaccine-targeted Pneumococcal Serotypes Among Adults. Epidemiology 2017, 28: 119-126. PMID: 27541841, PMCID: PMC5131859, DOI: 10.1097/ede.0000000000000551.Peer-Reviewed Original ResearchConceptsVaccine-targeted serotypesInvasive pneumococcal disease casesPneumococcal disease casesDirect vaccinationDisease casesInvasive pneumococcal diseaseConjugate vaccinePneumococcal diseaseVaccine serotypesVaccine uptakePneumococcal serotypesLeading causeBaseline proportionRate of declineNumber of casesAdult populationVaccinationStudy periodVaccineSerotypesAdultsChildrenHigh levelsMorbidityGeographic regions
2012
Spatial-Temporal Modeling of the Association Between Air Pollution Exposure and Preterm Birth: Identifying Critical Windows of Exposure
Warren J, Fuentes M, Herring A, Langlois P. Spatial-Temporal Modeling of the Association Between Air Pollution Exposure and Preterm Birth: Identifying Critical Windows of Exposure. Biometrics 2012, 68: 1157-1167. PMID: 22568640, PMCID: PMC3422613, DOI: 10.1111/j.1541-0420.2012.01774.x.Peer-Reviewed Original Research
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