2024
Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India
Shah D, Bhide S, Deshmukh R, Smith J, Kaiplyawar S, Puri V, Yeldandi V, Date A, Nyendak M, Ho C, Moonan P. Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India. Frontiers In Tuberculosis 2024, 2: 1454277. PMID: 39421397, PMCID: PMC11485165, DOI: 10.3389/ftubr.2024.1454277.Peer-Reviewed Original ResearchInterferon-gamma release assayTB preventive treatmentTB infectionHousehold contactsDrug-susceptible pulmonary tuberculosisTB diseaseTreat approachProgression to active TB diseaseDrug-susceptible pulmonary TBRate of TB infectionPrevalence of TB infectionActive TB diseaseAge 5 yearsSecondary TB casesCross-sectional studyAntituberculosis treatmentIGRA testPulmonary TBPulmonary tuberculosisTuberculosis infectionInterferon-gammaRelease assayClinical evaluationEarly diagnosisTreat strategy
2023
Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children
Smith J, Milligan K, McCarthy K, Mchembere W, Okeyo E, Musau S, Okumu A, Song R, Click E, Cain K. Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children. PLOS Digital Health 2023, 2: e0000249. PMID: 37195976, PMCID: PMC10191346, DOI: 10.1371/journal.pdig.0000249.Peer-Reviewed Original ResearchMicrobial confirmationTB diseaseYoung childrenNoninvasive procedureLarge prospective cohortCases of tuberculosisChest X-rayDiagnosis of tuberculosisClinical decision makingBacteriologic confirmationHousehold contactsTB infectionProspective cohortRadiologic factorsPaucibacillary natureClinical similaritiesDiagnostic cohortClinical diseaseChildhood diseasesInvasive proceduresNovel biomarkersTuberculosisClinical researchM. tuberculosisDisease