2025
Filling the Gaps in PFAS Detection: Integrating GC-MS Non-Targeted Analysis for Comprehensive Environmental Monitoring and Exposure Assessment
Newton S, Bowden J, Charest N, Jackson S, Koelmel J, Liberatore H, Lin A, Lowe C, Nieto S, Pollitt K, Robuck A, Rostkowski P, Townsend T, Wallace M, Williams A. Filling the Gaps in PFAS Detection: Integrating GC-MS Non-Targeted Analysis for Comprehensive Environmental Monitoring and Exposure Assessment. Environmental Science & Technology Letters 2025, 12: 104-112. DOI: 10.1021/acs.estlett.4c00930.Peer-Reviewed Original ResearchNon-target analysisLC-ESI-MSLC-MSNovel PFASsChromatography-mass spectrometryNTA studiesGC-MSTransformation productsPFAS structuresPFAS chemistryLiquid chromatography-mass spectrometryPolyfluoroalkyl substancesGC-MS methodPFAS researchGas chromatography-mass spectrometryLC-MS analysisChemical spaceParent compoundAqueous filmSpectrometryPFAS detectionsChemicalSources of PFASsCompoundsChemistry
2024
Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice
Liu S, Dukes D, Koelmel J, Stelben P, Finch J, Okeme J, Lowe C, Williams A, Godri D, Rennie E, Parry E, McDonough C, Pollitt K. Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice. Environmental Science And Technology 2024, 59: 119-131. PMID: 39704186, DOI: 10.1021/acs.est.4c07750.Peer-Reviewed Original ResearchConceptsMass spectral libraryTransformation productsLiquid chromatography-high resolution mass spectrometryProduct libraryPolyfluoroalkyl substancesBiological transformation productsSpectral libraryFragmentation rulesBehavior of PFASPotential transformation productsMass spectrometryToxicity predictionChemical subclassesReaction productsLiver S9 fractionBiotransformation productsEnzymatic reactionsMutagenic toxicityReactionMouse liver S9 fractionBiological systemsS9 fractionDealkylationChemicalSpectrometryLandfill Gas: A Major Pathway for Neutral Per- and Polyfluoroalkyl Substance (PFAS) Release
Lin A, Thompson J, Koelmel J, Liu Y, Bowden J, Townsend T. Landfill Gas: A Major Pathway for Neutral Per- and Polyfluoroalkyl Substance (PFAS) Release. Environmental Science & Technology Letters 2024, 11: 730-737. DOI: 10.1021/acs.estlett.4c00364.Peer-Reviewed Original ResearchNeutral polyfluoroalkyl substancesPolyfluoroalkyl substancesFluorotelomer alcoholsLandfill gasLandfill leachateMunicipal solid waste landfillsSecondary fluorotelomer alcoholIonic PFASsSolid waste landfillsIssue of environmental pollutionXAD-2 resinLandfilled refuseWaste landfillsFluorotelomerLandfillEnvironmental pollutionXAD-2LeachatePolyfluoroalkylConsumer productsSampling approachMajor pathwaysFluorotelomer olefinsPollutionPerfluoroalkyl
2022
Occurrence and contamination profile of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in Belgian wastewater using target, suspect and non-target screening approaches
Jeong Y, Da Silva KM, Iturrospe E, Fuiji Y, Boogaerts T, van Nuijs ALN, Koelmel J, Covaci A. Occurrence and contamination profile of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in Belgian wastewater using target, suspect and non-target screening approaches. Journal Of Hazardous Materials 2022, 437: 129378. PMID: 35897185, DOI: 10.1016/j.jhazmat.2022.129378.Peer-Reviewed Original ResearchConceptsWastewater treatment plantsTreatment plantsAqueous filmMass loadNon-target screening approachPolyfluoroalkyl substancesWastewaterComprehensive investigationFoamPerfluorooctanoic acidFluorotelomer carboxylic acidFilmsHigher valuesPerfluorobutanoic acidPredominant PFASsLoadNon-target screeningConfidence levelCatchment areaNon-target screening method
2021
Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS)
Hagstrom AL, Anastas P, Boissevain A, Borrel A, Deziel NC, Fenton SE, Fields C, Fortner JD, Franceschi-Hofmann N, Frigon R, Jin L, Kim JH, Kleinstreuer NC, Koelmel J, Lei Y, Liew Z, Ma X, Mathieu L, Nason SL, Organtini K, Oulhote Y, Pociu S, Godri Pollitt KJ, Saiers J, Thompson DC, Toal B, Weiner EJ, Whirledge S, Zhang Y, Vasiliou V. Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS). The Science Of The Total Environment 2021, 778: 146192. PMID: 33714836, DOI: 10.1016/j.scitotenv.2021.146192.Peer-Reviewed Original Research
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