2025
Applying multilevel selection to understand cancer evolution and progression
Laplane L, Lamoureux A, Richker H, Alcaraz G, Fortunato A, Shaffer Z, Aktipis A, Mischel P, Plutynski A, Townsend J, Maley C. Applying multilevel selection to understand cancer evolution and progression. PLOS Biology 2025, 23: e3003290. PMID: 40680084, PMCID: PMC12303392, DOI: 10.1371/journal.pbio.3003290.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionCell ProliferationDisease ProgressionHumansNeoplasmsSelection, Genetic
2011
SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
Guo Z, Adomas AB, Jackson ED, Qin H, Townsend JP. SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae. FEMS Yeast Research 2011, 11: 345-355. PMID: 21306556, DOI: 10.1111/j.1567-1364.2011.00723.x.Peer-Reviewed Original ResearchMeSH KeywordsCell CycleCell ProliferationGene Expression ProfilingGene Expression Regulation, FungalGenes, FungalHSP30 Heat-Shock ProteinsHydrogen PeroxideMicrobial ViabilityMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsOligonucleotide Array Sequence AnalysisPhenotypePolymerase Chain ReactionSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSirtuin 2Up-RegulationConceptsReplicative agingWhole genome gene expressionNatural S. cerevisiaeExpression levelsLife span variationDifferential expression levelsDifferent expression levelsEffects of genesNatural populationsYeast SaccharomycesOrganelle organizationS. cerevisiaeGene expressionNatural variationCell cycleStress responseSir2Mitochondrial functionGenesSaccharomycesAllelic associationSpan variationProgenyMetabolic responseTim17
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