2024
Transcription factor-dependent regulatory networks of sexual reproduction in Fusarium graminearum
Kim W, Kim D, Wang Z, Liu M, Townsend J, Trail F. Transcription factor-dependent regulatory networks of sexual reproduction in Fusarium graminearum. MBio 2024, 16: e03030-24. PMID: 39589130, PMCID: PMC11708053, DOI: 10.1128/mbio.03030-24.Peer-Reviewed Original ResearchMating-type locusSexual reproductionKnockout mutantsTranscription factorsTranscriptome dataStage of sexual developmentRegulatory networksTranscriptional cascadeDevelopmental phenotypesSexual developmentAscospore productionRegulation of sexual developmentUpstream activatorSexual fruiting bodiesTranscriptional regulatory cascadeMulticellular body planRegulate sexual developmentMultiple transcription factorsFusarium graminearumSystems biology approachComplex reproductive biologyEarly stages of sexual developmentArrest phenotypeTF networksFilamentous fungi
2016
PhyloOncology: Understanding cancer through phylogenetic analysis
Somarelli JA, Ware KE, Kostadinov R, Robinson JM, Amri H, Abu-Asab M, Fourie N, Diogo R, Swofford D, Townsend JP. PhyloOncology: Understanding cancer through phylogenetic analysis. Biochimica Et Biophysica Acta (BBA) - Reviews On Cancer 2016, 1867: 101-108. PMID: 27810337, PMCID: PMC9583457, DOI: 10.1016/j.bbcan.2016.10.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdaptation, PhysiologicalAlgorithmsAnimalsBiomarkers, TumorCell Transformation, NeoplasticEvolution, MolecularGene Expression Regulation, NeoplasticGenetic FitnessGenetic Predisposition to DiseaseGenomicsHeredityHumansModels, GeneticMutationNeoplasmsPedigreePhenotypePhylogenySignal TransductionSystems BiologyTime FactorsConceptsDr. Robert A. GatenbyGenome-scale dataSystems biology approachPowerful systems biology approachUse of phylogeneticsPhylogenetic analysisBiology approachPhylogenetic applicationsSubclonal evolutionCancer biologyCancer progressionSuite of algorithmsPhylogeneticsCancer data setsCancer samplesImproved therapeutic interventionRobust approachDecades of researchFundamental insightsNew toolBiologyDiverse fieldsGatenbyData setsTherapeutic interventions
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