2025
95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa
Orfano A, Cisse A, Sheng Z, Guo Y, Han L, Thiam L, Mangou K, Moore A, Ba A, Li R, Pouye M, Diallo F, Sene S, Ngom E, Sadio B, Mbengue A, Membi C, Bazié T, Somé F, Olson N, Patel S, Shapiro L, Parikh S, Foy B, Cappello M, Premji Z, Dabiré R, Ouedraogo J, Bei A. 95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa. Journal Of Clinical And Translational Science 2025, 9: 29-29. PMCID: PMC12050472, DOI: 10.1017/cts.2024.767.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsTransmission-blocking vaccinesGenetic diversityComplex infectionSymptomatic P. falciparum infectionsMalaria transmission-blocking vaccineVaccine candidatesVariant frequenciesNovel single nucleotide polymorphismsNonsynonymous single nucleotide polymorphismsRare variantsFrequency of single nucleotide polymorphismsP. falciparum 3D7Plasmodium falciparum samplesAmplicon deep sequencingMalaria eliminationCountry-specific prevalenceEndemic African countriesPfs25 proteinGeneious softwareParasite genetic diversityProportion of mutant allelesAmplicon sequencingPfs25Mutant alleles
2014
Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions
Da D, Churcher T, Yerbanga R, Yaméogo B, Sangaré I, Ouedraogo J, Sinden R, Blagborough A, Cohuet A. Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions. Experimental Parasitology 2014, 149: 74-83. PMID: 25541384, DOI: 10.1016/j.exppara.2014.12.010.Peer-Reviewed Original ResearchConceptsGametocyte densityParasite densityBlood samplesInfected bloodMouse bloodInfectious blood samplesMembrane feeding assaysPlasmodium berghei infectionTransmission-reducing interventionsPlasmodium falciparum samplesBlood dilutionEvaluation of transmissionInfected mouse bloodBerghei infectionPlasmodium infectionMosquito infectivityAnopheles coluzzii mosquitoesInhibitory factorMonoclonal antibodiesBloodAccurate relative measuresInfectionUninfected bloodHost bloodColuzzii mosquitoes
2013
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto O, Almagro-Garcia J, Manske M, MacInnis B, Campino S, Rockett K, Amaratunga C, Lim P, Suon S, Sreng S, Anderson J, Duong S, Nguon C, Chuor C, Saunders D, Se Y, Lon C, Fukuda M, Amenga-Etego L, Hodgson A, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su X, Ringwald P, Ariey F, Dolecek C, Hien T, Boni M, Thai C, Amambua-Ngwa A, Conway D, Djimdé A, Doumbo O, Zongo I, Ouedraogo J, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola S, Rayner J, Newbold C, Berriman M, Spencer C, McVean G, Day N, White N, Bethell D, Dondorp A, Plowe C, Fairhurst R, Kwiatkowski D. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature Genetics 2013, 45: 648-655. PMID: 23624527, PMCID: PMC3807790, DOI: 10.1038/ng.2624.Peer-Reviewed Original ResearchConceptsArtemisinin-resistant Plasmodium falciparumPlasmodium falciparum samplesArtemisinin resistancePlasmodium falciparumDistinct subpopulations
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