2025
95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa
Orfano A, Cisse A, Sheng Z, Guo Y, Han L, Thiam L, Mangou K, Moore A, Ba A, Li R, Pouye M, Diallo F, Sene S, Ngom E, Sadio B, Mbengue A, Membi C, Bazié T, Somé F, Olson N, Patel S, Shapiro L, Parikh S, Foy B, Cappello M, Premji Z, Dabiré R, Ouedraogo J, Bei A. 95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa. Journal Of Clinical And Translational Science 2025, 9: 29-29. PMCID: PMC12050472, DOI: 10.1017/cts.2024.767.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsTransmission-blocking vaccinesGenetic diversityComplex infectionSymptomatic P. falciparum infectionsMalaria transmission-blocking vaccineVaccine candidatesVariant frequenciesNovel single nucleotide polymorphismsNonsynonymous single nucleotide polymorphismsRare variantsFrequency of single nucleotide polymorphismsP. falciparum 3D7Plasmodium falciparum samplesAmplicon deep sequencingMalaria eliminationCountry-specific prevalenceEndemic African countriesPfs25 proteinGeneious softwareParasite genetic diversityProportion of mutant allelesAmplicon sequencingPfs25Mutant alleles
2011
Population Genetic Analysis of Plasmodium falciparum Parasites Using a Customized Illumina GoldenGate Genotyping Assay
Campino S, Auburn S, Kivinen K, Zongo I, Ouedraogo J, Mangano V, Djimde A, Doumbo O, Kiara S, Nzila A, Borrmann S, Marsh K, Michon P, Mueller I, Siba P, Jiang H, Su X, Amaratunga C, Socheat D, Fairhurst R, Imwong M, Anderson T, Nosten F, White N, Gwilliam R, Deloukas P, MacInnis B, Newbold C, Rockett K, Clark T, Kwiatkowski D. Population Genetic Analysis of Plasmodium falciparum Parasites Using a Customized Illumina GoldenGate Genotyping Assay. PLOS ONE 2011, 6: e20251. PMID: 21673999, PMCID: PMC3108946, DOI: 10.1371/journal.pone.0020251.Peer-Reviewed Original ResearchConceptsPopulation genetic studiesIllumina GoldenGateGenetic studiesSingle nucleotide polymorphism (SNP) discoveryLarge-scale population genetic studiesLaboratory clonesPopulation genetic diversityPopulation genetic analysesGenome sequencing projectsPlasmodium falciparum genomeTotal genomic DNAParasite population dynamicsMinor frequency allelesFalciparum genomePolymorphism discoveryGenetic diversitySequencing projectsWhole genomeP. falciparumGenetic analysisImportant phenotypesGenomic DNAHigh SNPPopulation dynamicsMultiple-clone infections
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