2022
Seasonal use case for the RTS,S/AS01 malaria vaccine: a mathematical modelling study
Thompson H, Hogan A, Walker P, Winskill P, Zongo I, Sagara I, Tinto H, Ouedraogo J, Dicko A, Chandramohan D, Greenwood B, Cairns M, Ghani A. Seasonal use case for the RTS,S/AS01 malaria vaccine: a mathematical modelling study. The Lancet Global Health 2022, 10: e1782-e1792. PMID: 36400084, DOI: 10.1016/s2214-109x(22)00416-8.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionSeasonal transmission settingsS vaccinationTransmission settingsTransmission seasonFull therapeutic coursePhase 3b trialSevere malaria outcomesUK Medical Research CouncilEstimates of casesDuration of protectionMalaria transmission intensityEntomological inoculation rateGreater absolute reductionMedical Research CouncilTransmission intensitySignificant additional protectionAge-based strategiesMalaria outcomesClinical malariaMalaria chemopreventionVaccination scheduleMalaria vaccineClinical incidenceClinical trials
2019
Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
Dahal P, Simpson J, Abdulla S, Achan J, Adam I, Agarwal A, Allan R, Anvikar A, Arinaitwe E, Ashley E, Awab G, Bassat Q, Björkman A, Bompart F, Borrmann S, Bousema T, Broek I, Bukirwa H, Carrara V, Corsi M, Cot M, D’Alessandro U, Davis T, de Wit M, Deloron P, Desai M, Dimbu P, Djalle D, Djimde A, Dorsey G, Doumbo O, Drakeley C, Duparc S, Edstein M, Espie E, Faiz A, Falade C, Fanello C, Faucher J, Faye B, de Jesus Fortes F, Gadalla N, Gaye O, Gil J, Greenwood B, Grivoyannis A, Hamed K, Hien T, Hughes D, Humphreys G, Hwang J, Ibrahim M, Janssens B, Jullien V, Juma E, Kamugisha E, Karema C, Karunajeewa H, Kiechel J, Kironde F, Kofoed P, Kremsner P, Lameyre V, Lee S, Marsh K, Mårtensson A, Mayxay M, Menan H, Mens P, Mutabingwa T, Ndiaye J, Ngasala B, Noedl H, Nosten F, Offianan A, Oguike M, Ogutu B, Olliaro P, Ouedraogo J, Piola P, Plowe C, Plucinski M, Pratt O, Premji Z, Ramharter M, Rogier C, Rombo L, Rosenthal P, Sawa P, Schramm B, Sibley C, Sinou V, Sirima S, Smithuis F, Staedke S, Sutanto I, Talisuna A, Tarning J, Taylor W, Temu E, Thriemer K, Thuy N, Udhayakumar V, Ursing J, van Herp M, van Vugt M, Whitty C, William Y, Winnips C, Zongo I, Guerin P, Price R, Stepniewska K. Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis. Malaria Journal 2019, 18: 225. PMID: 31277713, PMCID: PMC6612160, DOI: 10.1186/s12936-019-2837-4.Peer-Reviewed Original ResearchConceptsPlasmodium falciparum malariaFollow-up periodCumulative incidence functionFalciparum malariaRisk of recrudescenceUncomplicated Plasmodium falciparum malariaAntimalarial drug trialsLog-rank testProportion of patientsK-M curvesKaplan-Meier (K-M) methodData Meta-AnalysisK-M methodSub-distribution hazard modelCause-specific Cox modelsAntimalarial trialsIndividual Participant Data Meta-AnalysisParticipant data meta-analysisAntimalarial efficacyAbsolute overestimationKaplan-MeierFollow-upPrimary infectionTransmission settingsConclusionsThe 1
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