Performance characteristics and potential public health impact of improved pre-erythrocytic malaria vaccines targeting childhood burden
Malinga J, Braunack-Mayer L, Masserey T, Cavelan A, Chandramohan D, Dicko A, Ouédraogo J, Kelly S, Le Rutte E, Nekkab N, Penny M. Performance characteristics and potential public health impact of improved pre-erythrocytic malaria vaccines targeting childhood burden. PLOS Global Public Health 2025, 5: e0004549. PMID: 40758687, PMCID: PMC12321141, DOI: 10.1371/journal.pgph.0004549.Peer-Reviewed Original ResearchPre-erythrocytic vaccineMalaria vaccineChildhood malariaDuration of protectionIndividual-based model of malaria transmissionPre-erythrocytic malaria vaccineModel of malaria transmissionMalaria vaccine developmentRTS,SSevere childhood malariaRTS,S/AS01Public health impactIncidence reductionRoutine immunization programSeasonal vaccineMalaria transmissionClinical endpointsPotential public health impactVaccine efficacyPrimary vaccinationYear boosterMalariaVaccine developmentVaccine propertiesTrial dataThe anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E
Ali M, Stockdale L, Sagara I, Zongo I, Yerbanga R, Mahamar A, Nikièma F, Tapily A, Sompougdou F, Diarra M, Bellamy D, Provstgaard-Morys S, Zoungrana C, Issiaka D, Haro A, Sanogo K, Sienou A, Kaya M, Traore S, Dicko O, Kone Y, Yalcouye H, Thera I, Diarra K, Snell P, Ofori-Anyinam O, Ockenhouse C, Lee C, Ewer K, Tinto H, Djimde A, Ouedraogo J, Dicko A, Chandramohan D, Greenwood B. The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E. Npj Vaccines 2025, 10: 26. PMID: 39915506, PMCID: PMC11802723, DOI: 10.1038/s41541-025-01078-0.Peer-Reviewed Original ResearchDoses of RTS,S/AS01RTS,S/AS01Dose of vaccineBooster dose of vaccineBooster doseAntibody responseCircumsporozoite proteinMalaria-endemic areas of AfricaRTS,S/AS01E malaria vaccineAnti-CSP antibody responsesAntibody titresBurden of malariaMalaria transmission seasonMalaria-endemic areasAnti-CSP antibodiesPlasmodium falciparum sporozoitesRisk of malariaMalaria vaccine RTS,S/AS01Incidence of malariaAssociated with protectionMultiplex assayYears of ageSevere malariaMalaria vaccineS/AS01
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