2025
The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E
Ali M, Stockdale L, Sagara I, Zongo I, Yerbanga R, Mahamar A, Nikièma F, Tapily A, Sompougdou F, Diarra M, Bellamy D, Provstgaard-Morys S, Zoungrana C, Issiaka D, Haro A, Sanogo K, Sienou A, Kaya M, Traore S, Dicko O, Kone Y, Yalcouye H, Thera I, Diarra K, Snell P, Ofori-Anyinam O, Ockenhouse C, Lee C, Ewer K, Tinto H, Djimde A, Ouedraogo J, Dicko A, Chandramohan D, Greenwood B. The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E. Npj Vaccines 2025, 10: 26. PMID: 39915506, PMCID: PMC11802723, DOI: 10.1038/s41541-025-01078-0.Peer-Reviewed Original ResearchDoses of RTS,S/AS01RTS,S/AS01Dose of vaccineBooster dose of vaccineBooster doseAntibody responseCircumsporozoite proteinMalaria-endemic areas of AfricaRTS,S/AS01E malaria vaccineAntibody titresAnti-CSP antibody responsesBurden of malariaMalaria transmission seasonMalaria-endemic areasAnti-CSP antibodiesPlasmodium falciparum sporozoitesRisk of malariaMalaria vaccine RTS,S/AS01Incidence of malariaAssociated with protectionMultiplex assayYears of ageSevere malariaMalaria vaccineS/AS01
1990
Vaccination against malaria: initial trial with an ant-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso).
Guiguemdé T, Sturchler D, Ouédraogo J, Drabo M, Etlinger H, Douchet C, Gbary A, Haller L, Kambou S, Fernex M. Vaccination against malaria: initial trial with an ant-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso). Bulletin De La Société De Pathologie Exotique 1990, 83: 217-27. PMID: 2119897.Peer-Reviewed Original ResearchConceptsDoses of TTAntibody titresCircumsporozoite proteinAverage antibody titresPeak IgG responseMonths of ageClinical malariaIgG responsesSystemic reactionsProtective efficacyVaccine trialsImmunological statusImmunisation vaccinesTetanus toxoidProtective effectGroup IIMalaria transmissionDay 0VaccineGroup IGroup IIIPlasmodium falciparumDay 75MalariaDay 150
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