2016
Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of <I>Cassia alata</I> L. (Fabaceae)
Da O, Yerbanga R, Traore/Coulibaly M, Koama B, Kabre Z, Tamboura S, Dakuyo Z, Sekhoacha M, Matsabisa M, Nikiema J, Ouedraogo J, Ouedraogo G. Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae). Pakistan Journal Of Biological Sciences 2016, 19: 171-178. PMID: 29022993, DOI: 10.3923/pjbs.2016.171.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimalarialsCassiaDisease Models, AnimalFemaleLethal Dose 50L-Lactate DehydrogenaseMalaria, FalciparumMaleMaximum Tolerated DoseMethanolMethylene ChlorideMiceParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant LeavesPlants, MedicinalPlasmodium falciparumProtozoan ProteinsSolventsConceptsVivo antiplasmodial activityBody weightAntiplasmodial activityPlasmodium falciparumMean percent suppressionDay suppressive testChloroquine-sensitive strainNon-lethal doseParasite lactate dehydrogenase assayAnimal body weightMaximum non-lethal doseMethanol leaf extractSuppressive testSignificant changesLactate dehydrogenase assayOral routePercent suppressionHematological parametersHigh dosesHaematological parametersPlasmodium bergheiMiceAntimalarial potentialLeaf extractCassia alata
2015
Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso
Tahita M, Tinto H, Yarga S, Kazienga A, Traore/Coulibaly M, Valea I, Van Overmeir C, Rosanas-Urgell A, Ouedraogo J, Guiguemde R, van Geertruyden J, Erhart A, D’Alessandro U. Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso. Malaria Journal 2015, 14: 251. PMID: 26088768, PMCID: PMC4474342, DOI: 10.1186/s12936-015-0769-1.Peer-Reviewed Original ResearchMeSH KeywordsAntimalarialsBurkina FasoDrug ResistanceFemaleHumansInhibitory Concentration 50Malaria, FalciparumParasitic Sensitivity TestsPlasmodium falciparumPregnancySeasonsConceptsPregnant womenAnti-malarial drugsDrug sensitivity profilesParasite densityAnti-malarial drug susceptibilityDifferent drug sensitivity profilesUncomplicated Plasmodium falciparum malariaTreatment Efficacy TrialInfected pregnant womenArtemisinin-based combinationsPlasmodium falciparum malariaChloroquine-resistant isolatesHistidine-rich protein-2 assayPlasmodium falciparum isolatesGeometric mean IC50Low parasite densitiesP. falciparum parasitesTreatment of malariaFalciparum malariaRecurrent infectionsMean IC50Efficacy trialsFalciparum isolatesMethodsThe studyResistant parasites
2014
Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change
Tinto H, Bonkian L, Nana L, Yerbanga I, Lingani M, Kazienga A, Valéa I, Sorgho H, Kpoda H, Guiguemdé T, Ouédraogo J, Mens P, Schallig H, D’Alessandro U. Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change. Malaria Journal 2014, 13: 207. PMID: 24885950, PMCID: PMC4049403, DOI: 10.1186/1475-2875-13-207.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntimalarialsBurkina FasoChildChild, PreschoolFemaleHumansInfantInhibitory Concentration 50Malaria, FalciparumMaleParasitic Sensitivity TestsPlasmodium falciparumConceptsP. falciparum sensitivityVivo studiesFirst-line treatmentPlasmodium falciparum fieldAnti-malarial drugsEx vivo studyDrug sensitivity profilesDHA-PPQChloroquine resistanceIC50 valuesPartner drugsDrug efficacy testsDrug measurementsInhibitory concentration valuesMonodesethylamodiaquinePiperaquineEfficacy of ALHigher IC50 valuesPlasmodium falciparumDihydroartemisininFive yearsCellular proliferationDrugsRecent reportsLumefantrine
2006
In vivo sensitivity of Plasmodium faciparum to chloroquine and sulfadoxine pyrimethamine in the Bobo Dioulasso region (1998-2001): risk factors associated with treatments failures to the two drugs.
Tinto H, Sanou B, Erhart A, D'Alessandro U, Ouédraogo J, Guiguemdé T. In vivo sensitivity of Plasmodium faciparum to chloroquine and sulfadoxine pyrimethamine in the Bobo Dioulasso region (1998-2001): risk factors associated with treatments failures to the two drugs. Bulletin De La Société De Pathologie Exotique 2006, 99: 161-5. PMID: 16983817.Peer-Reviewed Original ResearchConceptsCQ treatment failureTreatment failureRisk factorsMultivariate analysisVivo field testTotal treatment failureYears of ageTime of recruitmentSignificant increaseSulfadoxine-pyrimethamineCQ groupUnivariate analysisHealth centersAge of childrenLate failureLow parasitaemiaBetter efficacyDay 14Therapeutic efficacyDay 0SP groupVivo sensitivityParasitaemiaChloroquineDrugs
2002
Chloroquine and sulphadoxine‐pyrimethamine efficacy for uncomplicated malaria treatment and haematological recovery in children in Bobo‐Dioulasso, Burkina Faso during a 3‐year period 1998–2000
Tinto H, Zoungrana E, Coulibaly S, Ouedraogo J, Traoré M, Guiguemde T, Van Marck E, D'Alessandro U. Chloroquine and sulphadoxine‐pyrimethamine efficacy for uncomplicated malaria treatment and haematological recovery in children in Bobo‐Dioulasso, Burkina Faso during a 3‐year period 1998–2000. Tropical Medicine And International Health 2002, 7: 925-930. PMID: 12390597, DOI: 10.1046/j.1365-3156.2002.00952.x.Peer-Reviewed Original ResearchConceptsPrevalence of anemiaClinical failureParasitological resistancePacked cell volumeUncomplicated malariaDay 14Day 0Uncomplicated malaria treatmentHaematological recoveryMalaria treatmentCQ resistanceHealth centersRegular surveillanceAntimalarial drugsChloroquineBurkina FasoPrevalenceBobo-DioulassoChildrenAnemiaEvidence of increasesMalariaTreatmentFailureCell volume
2001
In vitro susceptibility of 232 isolates of Plasmodium falciparum to antimalarials in Burkina Faso (West Africa).
Tinto H, Ouedraogo J, Traoré B, Coulibaly S, Guiguemde T. In vitro susceptibility of 232 isolates of Plasmodium falciparum to antimalarials in Burkina Faso (West Africa). Bulletin De La Société De Pathologie Exotique 2001, 94: 188-91. PMID: 16579075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsAntimalarialsBurkina FasoChildChild, PreschoolHumansInfantParasitic Sensitivity TestsPlasmodium falciparumConceptsP. falciparumPlasmodium falciparumCells/mm3Chloroquine-resistant strainsInclusion criteriaReference centerParasite countsSingle infectionResistant isolatesSignificant positive correlationParasite growthPersistence of resistanceFalciparumHalofantrineBobo-DioulassoSignificant increaseMefloquineIC50 valuesPositive correlationIsolatesQuinineSusceptibilityPatientsBurkina FasoIncubation period