2016
Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso
Somé A, Sorgho H, Zongo I, Bazié T, Nikiéma F, Sawadogo A, Zongo M, Compaoré Y, Ouédraogo J. Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso. Parasite 2016, 23: 60. PMID: 28004634, PMCID: PMC5178381, DOI: 10.1051/parasite/2016069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, BacterialAntigens, SurfaceAntimalarialsArtemisininsBurkina FasoChildChild, PreschoolDrug ResistanceDrug Therapy, CombinationHumansInfantMalaria, FalciparumMembrane Transport ProteinsMultidrug Resistance-Associated ProteinsPlasmodium falciparumPolymorphism, Single NucleotideProtozoan ProteinsYoung AdultConceptsPolymerase chain reactionUncomplicated malariaDrug resistance polymorphismsPfcrt 76TResistance-mediating polymorphismsPrevalence of polymorphismsSymptomatic malaria patientsAntimalarial drug resistanceGlobal malaria controlEmergence of resistancePfmdr1 184FPfmdr1 86YMalaria patientsPfdhps genesBaseline prevalenceCombination therapyHealth centersBlood samplesWestern CambodiaBetter efficacyGene polymorphismsCodon 540Malaria controlDrug resistancePfdhps
2015
Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine
Tahita M, Tinto H, Erhart A, Kazienga A, Fitzhenry R, VanOvermeir C, Rosanas-Urgell A, Ouedraogo J, Guiguemde R, Van geertruyden J, D’Alessandro U. Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine. PLOS ONE 2015, 10: e0137440. PMID: 26368675, PMCID: PMC4569438, DOI: 10.1371/journal.pone.0137440.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntimalarialsBurkina FasoDihydropteroate SynthaseDrug CombinationsDrug ResistanceFemaleHumansMalaria, FalciparumMutationPlasmodium falciparumPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPrevalenceProtozoan ProteinsPyrimethamineSulfadoxineTetrahydrofolate DehydrogenaseYoung AdultConceptsIntermittent preventive treatmentPregnant womenPfdhps genesPreventive treatmentAntenatal careSulfadoxine-pyrimethamineThird trimesterDhps mutationsPfdhfr mutationsMalaria infectionMalaria symptomsHealth districtPfdhfr geneBlood samplesSP resistanceI164L mutationEndemic regionsReductase mutationMalaria controlDrug resistancePrevalenceAdverse effectsFive yearsWomenBurkina Faso