2019
OC 8721 WANECAM II – A CLINICAL TRIAL PROGRAMME TO ASSESS SAFETY, EFFICACY AND TRANSMISSION-BLOCKING PROPERTIES OF A NEW ANTIMALARIAL KAF156 (GANAPLACIDE) IN UNCOMPLICATED MALARIA IN WEST AND CENTRAL AFRICA
Djimde A, Grobusch M, Zoleko Manego R, Mombo-Ngoma G, Picot S, Sagara I, Sutherland C, Kone A, Doumbo O, Pedro Gil J, Björkman A, Borrmann S, Soulama I, Fofana B, Duparc S, Dicko A, Hughes D, Winnips C, Sirima S, Adehossi E, Ouedraogo J, Dembele L, Zongo I, Biguenet S, Ilboudo-Sanogo E, Fofana A. OC 8721 WANECAM II – A CLINICAL TRIAL PROGRAMME TO ASSESS SAFETY, EFFICACY AND TRANSMISSION-BLOCKING PROPERTIES OF A NEW ANTIMALARIAL KAF156 (GANAPLACIDE) IN UNCOMPLICATED MALARIA IN WEST AND CENTRAL AFRICA. BMJ Global Health 2019, 4: a17.3-a18. DOI: 10.1136/bmjgh-2019-edc.43.Peer-Reviewed Original ResearchTrial programNew antimalarial drug combinationMajor public health problemAntimalarial drug combinationsClinical trial programPublic health problemYears of ageNew antimalarial drugsClinical research teamRegulatory health authoritiesNew antimalarial treatmentsUncomplicated malariaFalciparum malariaAntimalarial treatmentPatient adherenceCombination therapySingle dosesClinical trialsClinical studiesKAF156Drug combinationsArtemisinin derivativesClinical developmentDrug development pipelineHealth problems
2014
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
Preston M, Campino S, Assefa S, Echeverry D, Ocholla H, Amambua-Ngwa A, Stewart L, Conway D, Borrmann S, Michon P, Zongo I, Ouédraogo J, Djimde A, Doumbo O, Nosten F, Pain A, Bousema T, Drakeley C, Fairhurst R, Sutherland C, Roper C, Clark T. A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains. Nature Communications 2014, 5: 4052. PMID: 24923250, PMCID: PMC4082634, DOI: 10.1038/ncomms5052.Peer-Reviewed Original ResearchConceptsMajor public health problemValuable public health toolSingle nucleotide polymorphismsPublic health problemDrug-resistant parasitesPublic health toolPlasmodium falciparum strainsGlobal eradication campaignHealth problemsFalciparum strainsCase managementHealth toolsPlasmodium falciparumParasite migrationElimination areaEradication campaignApicoplast genomeParasitesPolymorphismInfectionMalariaInternational air travelFalciparum
2013
Clinical signs and symptoms cannot reliably predict Plasmodium falciparum malaria infection in pregnant women living in an area of high seasonal transmission
Tahita M, Tinto H, Menten J, Ouedraogo J, Guiguemde R, van Geertruyden J, Erhart A, D’Alessandro U. Clinical signs and symptoms cannot reliably predict Plasmodium falciparum malaria infection in pregnant women living in an area of high seasonal transmission. Malaria Journal 2013, 12: 464. PMID: 24373481, PMCID: PMC3877878, DOI: 10.1186/1475-2875-12-464.Peer-Reviewed Original ResearchConceptsPregnant womenMalaria infectionRapid diagnostic testsCommon signsPredictive valuePlasmodium falciparum malaria infectionMajor public health problemDiagnostic testsCommon malaria symptomsHigh seasonal transmissionFalciparum malaria infectionHistory of feverSymptoms of malariaPublic health problemPositive predictive valueIntensity of transmissionClinical malariaClinical presentationGestational ageMalaria symptomsDistrict hospitalOverall prevalenceMaternity clinicsClinical signsEndemic countries