2022
Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials
Dewey K, Arnold C, Wessells K, Prado E, Abbeddou S, Adu-Afarwuah S, Ali H, Arnold B, Ashorn P, Ashorn U, Ashraf S, Becquey E, Brown K, Christian P, Colford J, Dulience S, Fernald L, Galasso E, Hallamaa L, Hess S, Humphrey J, Huybregts L, Iannotti L, Jannat K, Lartey A, Le Port A, Leroy J, Luby S, Maleta K, Matias S, Mbuya M, Mridha M, Nkhoma M, Null C, Paul R, Okronipa H, Ouédraogo J, Pickering A, Prendergast A, Ruel M, Shaikh S, Weber A, Wolff P, Zongrone A, Stewart C. Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials. American Journal Of Clinical Nutrition 2022, 116: 1314-1333. PMID: 36045000, DOI: 10.1093/ajcn/nqac232.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsLipid-based nutrient supplementsSevere wastingIndividual participant dataParticipant dataPassive control armStudy-level characteristicsSevere stuntingMo of ageFixed-effects modelNutrient supplementsHealthy child growthControl armChildren 6Inclusion criteriaEffect modifiersPreventive interventionsChild wastingGreater burdenSubgroup estimatesWastingChild growthYoung childrenStuntingRelative reductionSmall-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial
Abbeddou S, Jimenez E, Hess S, Somé J, Ouédraogo J, Brown K. Small-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial. European Journal Of Nutrition 2022, 61: 4107-4120. PMID: 35829783, PMCID: PMC9596589, DOI: 10.1007/s00394-022-02936-6.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortLipid-based nutrient supplementsIntervention cohortIntervention groupCluster-randomized community trialFat-free mass accretionAdditional zinc supplementationFat depositionTrial registrationThe studyCluster-randomized trial designDispersible tabletsMonths of ageExcessive fat depositionMorbidity treatmentNIC childrenNutrient supplementsBurkinabe childrenUS National InstitutesObesity riskZinc supplementationClinical trialsCommunity trialFat massTrial design
2021
Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials
Wessells K, Arnold C, Stewart C, Prado E, Abbeddou S, Adu-Afarwuah S, Arnold B, Ashorn P, Ashorn U, Becquey E, Brown K, Byrd K, Campbell R, Christian P, Fernald L, Fan Y, Galasso E, Hess S, Huybregts L, Jorgensen J, Kiprotich M, Kortekangas E, Lartey A, Le Port A, Leroy J, Lin A, Maleta K, Matias S, Mbuya M, Mridha M, Mutasa K, Naser A, Paul R, Okronipa H, Ouédraogo J, Pickering A, Rahman M, Schulze K, Smith L, Weber A, Zongrone A, Dewey K. Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials. American Journal Of Clinical Nutrition 2021, 114: 68-94. PMID: 34590114, PMCID: PMC8560313, DOI: 10.1093/ajcn/nqab276.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPrevalence of anemiaIndividual participant dataIron deficiencyRetinol-binding proteinEffect modifiersChild anemiaSmall-quantity lipid-based nutrient supplementationStatus outcomesIndividual-level effect modifiersLipid-based nutrient supplementationLipid-based nutrient supplementsParticipant dataIndividual-level modifiersIron deficiency anemiaFe/dMo of ageFixed-effects modelDeficiency anemiaChild's hemoglobinEffect modificationIron statusChildren 6Study design characteristicsPlasma zinc
2020
A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants
Toe L, Kerckhof F, De Bodt J, Morel F, Ouedraogo J, Kolsteren P, Van de Wiele T. A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants. FEMS Microbiology Ecology 2020, 96: fiaa105. PMID: 32568403, DOI: 10.1093/femsec/fiaa105.Peer-Reviewed Original ResearchConceptsLipid-based nutrient supplementsBifidobacterium relative abundanceFatty acid productionAcid productionBranched-chain fatty acid productionNew therapeutic pathsLower gut microbiota diversityGut microbiota compositionPublic health problemHuman Intestinal Microbial EcosystemGut microbiota diversityIntestinal microbial ecosystemShort-chain fatty acid productionNutrient supplementsUndernourished infantsUndernourished childrenDynamic gut modelDeath proportionsMicrobiota compositionColonic microbiotaHealth problemsNutritional statusTherapeutic pathFecal microbiotaMicrobiota diversity
2017
Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS)
Hess S, Peerson J, Becquey E, Abbeddou S, Ouédraogo C, Somé J, Jimenez E, Ouédraogo J, Vosti S, Rouamba N, Brown K. Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS). PLOS ONE 2017, 12: e0181770. PMID: 28771493, PMCID: PMC5542440, DOI: 10.1371/journal.pone.0181770.Peer-Reviewed Original ResearchConceptsLipid-based nutrient supplementsSmall-quantity lipid-based nutrient supplementsMorbidity burdenHealth districtZinc supplementation studiesMonths of enrollmentCross-trial differencesCommunity-based trialCommunity health workersAge z-scoreNon-intervention control groupMonths old childrenAge-adjusted changesVillage-based community health workersType of interventionMean LAZMorbidity surveillanceNutrient supplementsBaseline characteristicsDiarrhea treatmentLNS groupMean ageChild morbidityZinc supplementationAnthropometric assessmentAdditional Zinc Delivered as a Tablet and SQ‐LNS May Increase Fat Free Mass Accrual in Young Burkinabe Children
Jimenez E, Abbeddou S, Coulibaly N, Some J, Ouedraogo J, Brown K, Hess S. Additional Zinc Delivered as a Tablet and SQ‐LNS May Increase Fat Free Mass Accrual in Young Burkinabe Children. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.316.2.Peer-Reviewed Original ResearchNon-intervention cohortFat-free massSQ-LNSIntervention cohortDose groupMonths of ageBody compositionBurkinabe childrenNIC groupZinc tabletsSmall-quantity lipid-based nutrient supplementsBaseline fat-free massFree massLipid-based nutrient supplementsWeight gainYoung Burkinabe childrenChildren's body compositionCollection of salivaSubgroup of childrenTwo-stage clusterNIC childrenOverall weight gainFat massIC groupSupplemental zincSmall-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial
Abbeddou S, Yakes Jimenez E, Somé J, Ouédraogo J, Brown. K, Hess S. Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial. BMC Pediatrics 2017, 17: 46. PMID: 28152989, PMCID: PMC5288861, DOI: 10.1186/s12887-016-0765-9.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortLipid-based nutrient supplementsRetinol-binding proteinIntervention cohortAnemia prevalenceIllness treatmentIC childrenYoung Burkinabe childrenLower retinol-binding proteinSoluble transferrin receptorLower anemia prevalenceIron deficiency prevalenceCluster-randomized trialIndicators of ironPackage of interventionsIndicator of vitaminMonths of ageDifferent treatment groupsGroup-wise differencesTwo-stage clusterNIC childrenNutrient supplementsResultsAt baselineBurkinabe children
2016
Lipid-Based Nutrient Supplements Plus Malaria and Diarrhea Treatment Increase Infant Development Scores in a Cluster-Randomized Trial in Burkina Faso 1–3
Prado E, Abbeddou S, Yakes Jimenez E, Somé J, Ouédraogo Z, Vosti S, Dewey K, Brown K, Hess S, Ouédraogo J. Lipid-Based Nutrient Supplements Plus Malaria and Diarrhea Treatment Increase Infant Development Scores in a Cluster-Randomized Trial in Burkina Faso 1–3. Journal Of Nutrition 2016, 146: 814-822. PMID: 26962193, DOI: 10.3945/jn.115.225524.Peer-Reviewed Original ResearchAge 18 moPersonal-social developmentRural Burkina FasoSQ-LNSsIC groupLipid-based nutrient supplementsInfant Development scoresAge 9Treatment of malariaRapid brain developmentNutrient supplementsSecondary outcomesPlacebo tabletsAdequate nutritionIC subgroupBrain developmentIC childrenMalariaNonintervention cohortInfant developmentTrialsDevelopment scoresBurkina FasoChildrenTreatment
2015
Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial
Abbeddou S, Hess S, Yakes Jimenez E, Somé J, Vosti S, Guissou R, Ouédraogo J, Brown K. Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial. Maternal And Child Nutrition 2015, 11: 90-104. PMID: 25521188, PMCID: PMC6860357, DOI: 10.1111/mcn.12162.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPlasma zinc concentrationDispersible tabletsLipid-based nutrient supplementsCaregiver-reported adherenceMonths of supplementationDisappearance rateMonths of ageSubgroup of childrenWeekly adherenceIntervention trialsClinical trialsLow adherenceSupplementation trialAdherence dataHome visitsCaregiver interviewsZinc tabletsLack of changeChildren 11Zinc concentrationsStudy outcomesObservation periodAdherenceMonthsIodine status of young Burkinabe children receiving small-quantity lipid-based nutrient supplements and iodised salt: a cluster-randomised trial
Hess S, Abbeddou S, Jimenez E, Ouédraogo J, Brown K. Iodine status of young Burkinabe children receiving small-quantity lipid-based nutrient supplements and iodised salt: a cluster-randomised trial. British Journal Of Nutrition 2015, 114: 1829-1837. PMID: 26411504, DOI: 10.1017/s0007114515003554.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsLipid-based nutrient supplementsThyroid-stimulating hormoneNon-intervention cohortMonths of ageYoung Burkinabe childrenUrinary iodineNIC childrenBurkinabe childrenIodised saltNational salt iodization programSpot urinary iodineCluster-randomised trialSalt iodization programNutrient supplementsSalt iodisation programmeIodine statusLow T4Thyroglobulin concentrationIodization programTotal thyroxineBlood spotsI statusIC childrenCohortEffect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial
Somé J, Abbeddou S, Jimenez E, Hess S, Ouédraogo Z, Guissou R, Vosti S, Ouédraogo J, Brown K. Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial. BMJ Open 2015, 5: e007828. PMID: 26362661, PMCID: PMC4567679, DOI: 10.1136/bmjopen-2015-007828.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsAcute lower respiratory tract infectionSmall-quantity lipid-based nutrient supplementsIncidence of diarrheaLower respiratory tract infectionsUpper respiratory tract infectionLipid-based nutrient supplementsSQ-LNSCluster-randomised trialPlacebo tabletsLongitudinal prevalenceIntervention groupPreventive zinc supplementationFrequency of diarrheaMonths of ageYoung childrenRural Burkina FasoMorbidity surveillanceNutrient supplementsTract infectionsRespiratory infectionsUncomplicated diarrheaZinc supplementationDiarrheaFeverAnemia And Iron Supplementation Is Not Associated with Malaria in Young Burkinabe Children
Some J, Abbeddou S, Jimenez E, Ouedraogo Z, Ouedraogo J, Brown K, Hess S. Anemia And Iron Supplementation Is Not Associated with Malaria in Young Burkinabe Children. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.757.9.Peer-Reviewed Original ResearchLipid-based nutrient supplementsRapid diagnostic testsYoung Burkinabe childrenBurkinabe childrenIron supplementationFe supplementsPositive malaria rapid diagnostic testPositive rapid diagnostic testMalaria rapid diagnostic testsRandomized clinical trialsIncidence of malariaMo of ageMalaria episodesAntimalarial treatmentSevere anemiaModerate anemiaClinical trialsAnthelminthic treatmentHome visitsMalaria diagnosisHemoglobin concentrationMalaria incidenceIron treatmentDiagnostic testsMalariaAssociations between Linear Growth and Language Development in Ghana, Malawi, and Burkina Faso
Prado E, Abbeddou S, Adu‐Afarwuah S, Arimond M, Ashorn P, Ashorn U, Brown K, Hess S, Lartey A, Maleta K, Ocansey E, Ouedraogo J, Phuka J, Somé J, Vosti S, Jimenez E, Dewey K. Associations between Linear Growth and Language Development in Ghana, Malawi, and Burkina Faso. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.899.3.Peer-Reviewed Original ResearchLipid-based nutrient supplementsMaternal lipid-based nutrient supplementsSmall-Quantity Lipid-Based Nutrient Supplements, Regardless of Their Zinc Content, Increase Growth and Reduce the Prevalence of Stunting and Wasting in Young Burkinabe Children: A Cluster-Randomized Trial
Hess S, Abbeddou S, Jimenez E, Somé J, Vosti S, Ouédraogo Z, Guissou R, Ouédraogo J, Brown K. Small-Quantity Lipid-Based Nutrient Supplements, Regardless of Their Zinc Content, Increase Growth and Reduce the Prevalence of Stunting and Wasting in Young Burkinabe Children: A Cluster-Randomized Trial. PLOS ONE 2015, 10: e0122242. PMID: 25816354, PMCID: PMC4376671, DOI: 10.1371/journal.pone.0122242.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortPlacebo tabletsLipid-based nutrient supplementsYoung Burkinabe childrenOral rehydration saltsPrevalence of stuntingIncidence of diarrheaCluster-randomized trialPlasma zinc concentrationMonths of ageBaseline hemoglobinMorbidity surveillanceNutrient supplementsStandard careDiarrhea treatmentRehydration saltsAnemia prevalenceBurkinabe childrenIllness surveillanceAntimalarial therapyIntervention groupIllness treatmentZinc tabletsZinc levels
2014
Burkinabe infants given small quantity lipid‐based nutrient supplements and illness treatment in infancy score higher in motor, language, and personal‐social development (251.1)
Prado E, Abbeddou S, Jimenez E, Somé J, Ouédraogo Z, Vosti S, Dewey K, Hess S, Ouédraogo J, Brown K. Burkinabe infants given small quantity lipid‐based nutrient supplements and illness treatment in infancy score higher in motor, language, and personal‐social development (251.1). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.251.1.Peer-Reviewed Original ResearchSmall-quantity lipid-based nutrient supplementsLipid-based nutrient supplementsPersonal-social developmentNon-intervention communitiesYoung Burkinabe childrenTreatment of malariaMonths of ageRural Burkina FasoNutrient supplementsSQ-LNSBurkinabe childrenIllness treatmentBrain growthAdequate nutritionMacronutrient metabolismBrain developmentIC childrenMelinda Gates FoundationDevelopment of motorChildrenMalariaLowest decileTreatmentGrant funding sourcesSDAdherence to small‐quantity lipid based nutrient supplement among young Burkinabe children (624.19)
Abbeddou S, Hess S, Jimenez E, Somé J, Guissou R, Ouedraogo Z, Vosti S, Ouedraogo J, Brown K. Adherence to small‐quantity lipid based nutrient supplement among young Burkinabe children (624.19). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.624.19.Peer-Reviewed Original ResearchSQ-LNSDays/weekHome visitsSmall-quantity lipid-based nutrient supplementsLipid-based nutrient supplementsSmall-Quantity LipidYoung Burkinabe childrenRandomized clinical trialsReporting of adherenceWeekly home visitsDisappearance rateWeekly adherenceNutrient supplementsBurkinabe childrenClinical trialsSupplementation regimensCaregiver interviewsFull doseHome ObservationMelinda Gates FoundationOlder childrenObservation periodAdherenceChildrenGrant funding sources
2010
Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso
Hess S, Bado L, Aaron G, Ouédraogo J, Zeilani M, Brown K. Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso. Maternal And Child Nutrition 2010, 7: 357-367. PMID: 21159124, PMCID: PMC6860760, DOI: 10.1111/j.1740-8709.2010.00287.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBurkina FasoConsumer BehaviorDietary FatsDietary SupplementsDose-Response Relationship, DrugFemaleFocus GroupsHumansInfantInfant FoodInfant Nutritional Physiological PhenomenaInterviews as TopicMaleMicronutrientsNutritive ValueSocioeconomic FactorsSurveys and QuestionnairesYoung AdultZincConceptsLipid-based nutrient supplementsAcceptability studyYoung childrenPublic health concernPossible adverse effectsNutrient supplementsNutritional statusComplementary foodsChildren 9Health concernLow-income countriesMaternal reportsAdverse effectsTrialsChildren's consumptionMicronutrient deficienciesMothersChildrenGood acceptabilityDoseDetectable differenceTime of consumptionSupplementsNovel strategyDetection of differences