2020
A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants
Toe L, Kerckhof F, De Bodt J, Morel F, Ouedraogo J, Kolsteren P, Van de Wiele T. A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants. FEMS Microbiology Ecology 2020, 96: fiaa105. PMID: 32568403, DOI: 10.1093/femsec/fiaa105.Peer-Reviewed Original ResearchConceptsLipid-based nutrient supplementsBifidobacterium relative abundanceFatty acid productionAcid productionBranched-chain fatty acid productionNew therapeutic pathsLower gut microbiota diversityGut microbiota compositionPublic health problemHuman Intestinal Microbial EcosystemGut microbiota diversityIntestinal microbial ecosystemShort-chain fatty acid productionNutrient supplementsUndernourished infantsUndernourished childrenDynamic gut modelDeath proportionsMicrobiota compositionColonic microbiotaHealth problemsNutritional statusTherapeutic pathFecal microbiotaMicrobiota diversity
2019
OC 8721 WANECAM II – A CLINICAL TRIAL PROGRAMME TO ASSESS SAFETY, EFFICACY AND TRANSMISSION-BLOCKING PROPERTIES OF A NEW ANTIMALARIAL KAF156 (GANAPLACIDE) IN UNCOMPLICATED MALARIA IN WEST AND CENTRAL AFRICA
Djimde A, Grobusch M, Zoleko Manego R, Mombo-Ngoma G, Picot S, Sagara I, Sutherland C, Kone A, Doumbo O, Pedro Gil J, Björkman A, Borrmann S, Soulama I, Fofana B, Duparc S, Dicko A, Hughes D, Winnips C, Sirima S, Adehossi E, Ouedraogo J, Dembele L, Zongo I, Biguenet S, Ilboudo-Sanogo E, Fofana A. OC 8721 WANECAM II – A CLINICAL TRIAL PROGRAMME TO ASSESS SAFETY, EFFICACY AND TRANSMISSION-BLOCKING PROPERTIES OF A NEW ANTIMALARIAL KAF156 (GANAPLACIDE) IN UNCOMPLICATED MALARIA IN WEST AND CENTRAL AFRICA. BMJ Global Health 2019, 4: a17.3-a18. DOI: 10.1136/bmjgh-2019-edc.43.Peer-Reviewed Original ResearchTrial programNew antimalarial drug combinationMajor public health problemAntimalarial drug combinationsClinical trial programPublic health problemYears of ageNew antimalarial drugsClinical research teamRegulatory health authoritiesNew antimalarial treatmentsUncomplicated malariaFalciparum malariaAntimalarial treatmentPatient adherenceCombination therapySingle dosesClinical trialsClinical studiesKAF156Drug combinationsArtemisinin derivativesClinical developmentDrug development pipelineHealth problems
2014
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
Preston M, Campino S, Assefa S, Echeverry D, Ocholla H, Amambua-Ngwa A, Stewart L, Conway D, Borrmann S, Michon P, Zongo I, Ouédraogo J, Djimde A, Doumbo O, Nosten F, Pain A, Bousema T, Drakeley C, Fairhurst R, Sutherland C, Roper C, Clark T. A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains. Nature Communications 2014, 5: 4052. PMID: 24923250, PMCID: PMC4082634, DOI: 10.1038/ncomms5052.Peer-Reviewed Original ResearchConceptsMajor public health problemValuable public health toolSingle nucleotide polymorphismsPublic health problemDrug-resistant parasitesPublic health toolPlasmodium falciparum strainsGlobal eradication campaignHealth problemsFalciparum strainsCase managementHealth toolsPlasmodium falciparumParasite migrationElimination areaEradication campaignApicoplast genomeParasitesPolymorphismInfectionMalariaInternational air travelFalciparum
1997
Malaria morbidity in adults living in urban Burkina Faso.
Guiguemde T, Ouedraogo I, Ouedraogo J, Coulibaly S, Gbary A. Malaria morbidity in adults living in urban Burkina Faso. Medecine Tropicale 1997, 57: 165-8. PMID: 9304011.Peer-Reviewed Original ResearchConceptsLevel of immunizationPoor positive predictive valueSerious public health problemMain clinical featuresPublic health problemDiagnosis of malariaBobo-DioulassoPositive predictive valueParasitic indexMedian parasitemiaClinical featuresClinical symptomsMalaria morbidityProspective studyParasitological featuresParasite densityHigh incidencePlace of residencePredictive valueHealth problemsEndemic malariaMalariaUrban Burkina FasoAdultsMicroscopic examination