2023
Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study
Roh M, Zongo I, Haro A, Huang L, Somé A, Yerbanga R, Conrad M, Wallender E, Legac J, Aweeka F, Ouédraogo J, Rosenthal P. Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study. The Journal Of Infectious Diseases 2023, 228: 926-935. PMID: 37221018, PMCID: PMC10547452, DOI: 10.1093/infdis/jiad172.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionDrug levelsMonths of ageOdds ratioHigh-level SP resistanceSP-AQCase-control studyConditional logistic regressionLow drug levelsPrevalence of mutationsDrug resistance markersCase-control designResistance markersIncident malariaParasitemic childrenMalaria chemopreventionAntimalarial resistanceChildren 6Health facilitiesSP resistanceChildren 3Malaria incidenceDrug resistanceMalariaLogistic regression
2022
Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials
Dewey K, Arnold C, Wessells K, Prado E, Abbeddou S, Adu-Afarwuah S, Ali H, Arnold B, Ashorn P, Ashorn U, Ashraf S, Becquey E, Brown K, Christian P, Colford J, Dulience S, Fernald L, Galasso E, Hallamaa L, Hess S, Humphrey J, Huybregts L, Iannotti L, Jannat K, Lartey A, Le Port A, Leroy J, Luby S, Maleta K, Matias S, Mbuya M, Mridha M, Nkhoma M, Null C, Paul R, Okronipa H, Ouédraogo J, Pickering A, Prendergast A, Ruel M, Shaikh S, Weber A, Wolff P, Zongrone A, Stewart C. Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials. American Journal Of Clinical Nutrition 2022, 116: 1314-1333. PMID: 36045000, DOI: 10.1093/ajcn/nqac232.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsLipid-based nutrient supplementsSevere wastingIndividual participant dataParticipant dataPassive control armStudy-level characteristicsSevere stuntingMo of ageFixed-effects modelNutrient supplementsHealthy child growthControl armChildren 6Inclusion criteriaEffect modifiersPreventive interventionsChild wastingGreater burdenSubgroup estimatesWastingChild growthYoung childrenStuntingRelative reduction
2021
Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials
Wessells K, Arnold C, Stewart C, Prado E, Abbeddou S, Adu-Afarwuah S, Arnold B, Ashorn P, Ashorn U, Becquey E, Brown K, Byrd K, Campbell R, Christian P, Fernald L, Fan Y, Galasso E, Hess S, Huybregts L, Jorgensen J, Kiprotich M, Kortekangas E, Lartey A, Le Port A, Leroy J, Lin A, Maleta K, Matias S, Mbuya M, Mridha M, Mutasa K, Naser A, Paul R, Okronipa H, Ouédraogo J, Pickering A, Rahman M, Schulze K, Smith L, Weber A, Zongrone A, Dewey K. Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials. American Journal Of Clinical Nutrition 2021, 114: 68-94. PMID: 34590114, PMCID: PMC8560313, DOI: 10.1093/ajcn/nqab276.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPrevalence of anemiaIndividual participant dataIron deficiencyRetinol-binding proteinEffect modifiersChild anemiaSmall-quantity lipid-based nutrient supplementationStatus outcomesIndividual-level effect modifiersLipid-based nutrient supplementationLipid-based nutrient supplementsParticipant dataIndividual-level modifiersIron deficiency anemiaFe/dMo of ageFixed-effects modelDeficiency anemiaChild's hemoglobinEffect modificationIron statusChildren 6Study design characteristicsPlasma zinc
2016
Factors Affecting the Validity of Coverage Survey Reports of Receipt of Vitamin A Supplements During Child Health Days in Southwestern Burkina Faso
Ouédraogo C, Becquey E, Wilson S, Prince L, Ouédraogo A, Rouamba N, Ouédraogo J, Vosti S, Brown K, Hess S. Factors Affecting the Validity of Coverage Survey Reports of Receipt of Vitamin A Supplements During Child Health Days in Southwestern Burkina Faso. Food And Nutrition Bulletin 2016, 37: 529-543. PMID: 27604622, DOI: 10.1177/0379572116666167.Peer-Reviewed Original ResearchConceptsOral polio vaccineOdds ratioChildren 6High-dose vitaminVitamin A supplementsCross-sectional studyLongitudinal studyMonths old childrenCaregivers of childrenChild Health DaysMonths of ageCross-sectional surveyFalse positive reportingSupplementation coverageVAS coverageFalse positive reportsA supplementsOral vaccinePolio vaccineCoverage surveyHealth daysOlder childrenVASMonthsWeeks
2013
Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation
Wessells K, Hess S, Rouamba N, Ouédraogo Z, Kellogg M, Goto R, Duggan C, Ouédraogo J, Brown K. Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation. Journal Of Pediatric Gastroenterology And Nutrition 2013, 57: 348-355. PMID: 23689263, PMCID: PMC4627695, DOI: 10.1097/mpg.0b013e31829b4e9e.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsIntestinal mucosal functionMucosal functionCitrulline concentrationZn supplementationIntestinal function testsPlacebo-controlled trialMalabsorption of fatPlasma citrulline concentrationHealthy children 6Plasma zinc concentrationMonths of agePlacebo groupPlacebo supplementationUrinary lactuloseFunction testsIntestinal permeabilitySupplementation groupZinc supplementationChildren 6Vitamin AZinc absorptionDietary Zn absorptionSupplementationMineral absorptionComparison of preventive and therapeutic zinc supplementation programs for young children in Burkina Faso: a randomized, masked, community‐based trial
Becquey E, Ouedraogo C, Hess S, Rouamba N, Prince L, Vosti S, Ouedraogo J, Brown K. Comparison of preventive and therapeutic zinc supplementation programs for young children in Burkina Faso: a randomized, masked, community‐based trial. The FASEB Journal 2013, 27: 845.19-845.19. DOI: 10.1096/fasebj.27.1_supplement.845.19.Peer-Reviewed Original ResearchOral rehydration saltsDiarrhea incidenceSUPP groupThrasher Research FundCommunity-based trialLower diarrhea incidenceRehydration saltsUncomplicated diarrheaChildren 6Home visitsDiarrhea preventionControl groupZn supplementationDiarrheaSupplementation programsIncidenceGreat benefitFree treatmentYoung childrenTreatmentGroupFeverLess lengthBurkina FasoMalaria
2012
Vitamin A supplementation of young children in Burkina Faso, and risk factors for non‐coverage
Hess S, Ouédraogo C, Wilson S, Prince L, Rouamba N, Ouédraogo J, Vosti S, Dakkak M, Brown K. Vitamin A supplementation of young children in Burkina Faso, and risk factors for non‐coverage. The FASEB Journal 2012, 26: 1031.4-1031.4. DOI: 10.1096/fasebj.26.1_supplement.1031.4.Peer-Reviewed Original ResearchVitamin A supplementsVAS coverageChildren 6High-dose vitamin A supplementsThrasher Research FundYoung mothersCross-sectional household surveyHealth districtRisk factorsA supplementsBurkina FasoAge rangeChildrenYoung childrenSpecific targetingCaregiversStaff trainingMothersHousehold surveySupplementationIntestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation
Wessells K, Hess S, Ouédraogo Z, Rouamba N, Goto R, Ouédraogo J, Brown K. Intestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation. The FASEB Journal 2012, 26: 392.2-392.2. DOI: 10.1096/fasebj.26.1_supplement.392.2.Peer-Reviewed Original ResearchPlasma zinc concentrationIntestinal permeabilityShort-term zinc supplementationAltered intestinal permeabilityIntestinal mucosal functionMalabsorption of fatRandomized community trialSubclinical enteropathyPlacebo groupPlacebo supplementationMucosal functionZinc supplementationCommunity trialSupplementation periodChildren 6Study groupSD changeVitamin ASupplementation resultsZinc concentrationsZinc absorptionEnteropathyMineral absorptionGrant funding sourcesBaseline
2011
Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial
Wessells K, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial. The Journal Of Pediatrics 2011, 160: 129-135.e3. PMID: 21871635, DOI: 10.1016/j.jpeds.2011.06.051.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsPlasma zinc concentrationPlacebo groupZinc supplementationDispersible tabletsShort-term zinc supplementationPlacebo-controlled trialMain outcome measuresYoung childrenMonths of ageControlled TrialsPlacebo solutionChildren 6Outcome measuresSD changeSupplementation resultsZinc concentrationsZinc absorptionMean plusSupplementationBurkina FasoTrialsMonthsSimilar positive effectsAgeThe effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children
Wessells R, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. The effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children. The FASEB Journal 2011, 25: 236.1-236.1. DOI: 10.1096/fasebj.25.1_supplement.236.1.Peer-Reviewed Original ResearchPlasma zinc concentrationPlacebo groupZinc supplementationZinc supplementsPreventive zinc supplementationDispersible tabletsCause mortalityZinc concentrationsZn concPlacebo solutionChildren 6Study populationDaily supplementSD changeWeight gainZinc deficiencyZn supplementsFurther studiesYoung childrenDifferential changesSupplementationSupplementsChildrenGroupZinc sulfate