2021
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nature Genetics 2021, 53: 174-184. PMID: 33510476, PMCID: PMC7972521, DOI: 10.1038/s41588-020-00767-x.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisAssociation analysisMillion Veteran ProgramGenomic structural equation modelingSignificant lociGenetic varianceGene expressionDrug repositioning candidatesBiological coherenceVeteran ProgramMultiple testing correctionSymptom phenotypeLociRepositioning candidatesAfrican ancestryHeritabilityPhenotypeAncestryExpressionPTSD symptom factorsRegionSubdomainsEnrichmentGenomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006
Radhakrishnan K, Hauser ER, Polimanti R, Helmer DA, Provenzale D, McNeil RB, Maffucci A, Quaden R, Zhao H, Whitbourne SB, Harrington KM, Vahey J, Gelernter J, Levey DF, Huang GD, Gaziano JM, Concato J, Aslan M. Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006. Brain Sciences 2021, 11: 845. PMID: 34202057, PMCID: PMC8301942, DOI: 10.3390/brainsci11070845.Peer-Reviewed Original ResearchGulf War IllnessMillion Veteran ProgramVeterans Affairs Cooperative StudyChronic multi-symptom illnessNon-deployed veteransHealth care utilizationMulti-symptom illnessGenome-wide association studiesChart reviewPersian Gulf WarCare utilizationCase definitionMedical recordsDiseases codesHealth QuestionnaireInternational ClassificationGene-environment interactionsLarger sample sizeCase statusU.S. veteransMVP participantsClinical diagnosisCooperative StudyIllnessHealth conditionsGenomic and Phenomic Correlates of Suicidality Among US Veterans With Schizophrenia or Bipolar Disorder
Bigdeli T, Peterson R, Khankari N, Rajeevan N, Swann A, Sayward F, Meyers J, Li Y, Nielsen D, Wilkinson A, Graham D, O'Leary T, Zhao H, Cheung K, Mane S, Miller P, Brophy M, Program M, Przygodszki R, Siever L, Pyarajan S, Gleason T, Muralidhar S, Gaziano J, Concato J, Huang G, Fanous A, Aslan M, Kosten T, Harvey P. Genomic and Phenomic Correlates of Suicidality Among US Veterans With Schizophrenia or Bipolar Disorder. Biological Psychiatry 2021, 89: s237-s238. DOI: 10.1016/j.biopsych.2021.02.596.Peer-Reviewed Original Research
2019
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10: 1499. PMID: 30940813, PMCID: PMC6445072, DOI: 10.1038/s41467-019-09480-8.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesMillion Veteran Program sampleGenetic correlationsWide significant lociSignificant genetic correlationsPolygenic risk scoresCell type groupSignificant lociHeritable traitEnrichment analysisTraitsMultiple populationsLociPhenotypeProgram samplesAuthor Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10: 4050. PMID: 31481659, PMCID: PMC6722074, DOI: 10.1038/s41467-019-11916-0.Peer-Reviewed Original ResearchAuthor Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10: 2275. PMID: 31101824, PMCID: PMC6525240, DOI: 10.1038/s41467-019-10254-5.Peer-Reviewed Original ResearchSTUDIES ON ALCOHOL DEPENDENCE GENETICS FROM YALE-PENN AND THE MVP
Gelernter J, Sun N, Polimanti R, Zhou H, Levey D, Harrington K, Gaziano M, Pyarajan S, Aslan M, Sayward F, Li B, Farrer L, Zhao H, Concato J, Stein M. STUDIES ON ALCOHOL DEPENDENCE GENETICS FROM YALE-PENN AND THE MVP. European Neuropsychopharmacology 2019, 29: s1035-s1036. DOI: 10.1016/j.euroneuro.2018.07.032.Peer-Reviewed Original ResearchRESULTS FROM THE USVA MVP PTSD COOPERATIVE STUDY GWAS: PCL TRAITS
Gelernter J, Sun N, Polimanti R, Zhou H, Pietrzak R, Levey D, Harrington K, Gaziano M, Pyarajan S, Radhakrishnan K, Hu Y, Li B, Zhao H, Concato J, Stein M. RESULTS FROM THE USVA MVP PTSD COOPERATIVE STUDY GWAS: PCL TRAITS. European Neuropsychopharmacology 2019, 29: s1055-s1056. DOI: 10.1016/j.euroneuro.2018.07.071.Peer-Reviewed Original Research
2022
Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis
Duong L, Djotsa A, Vahey J, Steele L, Quaden R, Harrington K, Ahmed S, Polimanti R, Streja E, Gaziano J, Concato J, Zhao H, Radhakrishnan K, Hauser E, Helmer D, Aslan M, Gifford E. Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis. International Journal Of Environmental Research And Public Health 2022, 20: 258. PMID: 36612580, PMCID: PMC9819371, DOI: 10.3390/ijerph20010258.Peer-Reviewed Original ResearchConceptsGulf War IllnessGulf War Era VeteransChronic multisymptom illnessStudy inclusion criteriaCross-sectional analysisGW theaterGW veteransMultisymptom illnessEligible participantsUncertain etiologyInclusion criteriaKS symptomsDisease controlIllnessEra veteransMilitary characteristicsVeteransCohortPersistent presencePhenotypeFurther explorationPathophysiologyEtiologySymptomsPrevalence
2018
159. GWAS of PTSD Re-experiencing Symptoms in the VA Million Veteran Program
Stein M, Gelernter J, Zhao H, Sun N, Pietrzak R, Harrington K, Cho K, Honerlaw J, Quaden R, Gaziano J, Concato J, MVP M. 159. GWAS of PTSD Re-experiencing Symptoms in the VA Million Veteran Program. Biological Psychiatry 2018, 83: s64-s65. DOI: 10.1016/j.biopsych.2018.02.177.Peer-Reviewed Original Research