2025
SuperGLUE facilitates an explainable training framework for multi-modal data analysis
Liu T, Zhao J, Zhao H. SuperGLUE facilitates an explainable training framework for multi-modal data analysis. Cell Reports Methods 2025, 5: 101167. PMID: 40914154, DOI: 10.1016/j.crmeth.2025.101167.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputational BiologyData AnalysisDeep LearningGene Regulatory NetworksHumansSingle-Cell AnalysisConceptsData integrationProbabilistic deep learningMulti-modal data analysisInference of gene regulatory networksMulti-modal data integrationDeep learningGene regulatory networksTraining frameworkBaseline modelRegulatory networksComplex biological systemsRegulatory relationshipsSensing dataCell statesGlobal structureArea of active researchActive researchOmicsBiological featuresScalable methodFrameworkBiological systemsStatistical modelNetworkBiological linkages
2024
mbDecoda: a debiased approach to compositional data analysis for microbiome surveys
Zong Y, Zhao H, Wang T. mbDecoda: a debiased approach to compositional data analysis for microbiome surveys. Briefings In Bioinformatics 2024, 25: bbae205. PMID: 38701410, PMCID: PMC11066923, DOI: 10.1093/bib/bbae205.Peer-Reviewed Original ResearchConceptsComposition of microbiomesCompositional biasMicrobiome datasetsMicrobiome studiesProbiotic microbesMicrobiome surveysMicrobiome compositionMicrobial loadMicrobiomeMaximum likelihood estimationAbundance analysisAbundance levelsAbsolute abundanceAbundance dataAbundanceClinical phenotypeFeature tableLikelihood estimation of model parametersEnvironmental factorsMaximum likelihood estimation of model parametersEstimation of model parametersMicrobesState-of-the-art methodsOver-dispersionState-of-the-art
2022
An unbiased kinship estimation method for genetic data analysis
Jiang W, Zhang X, Li S, Song S, Zhao H. An unbiased kinship estimation method for genetic data analysis. BMC Bioinformatics 2022, 23: 525. PMID: 36474154, PMCID: PMC9727941, DOI: 10.1186/s12859-022-05082-2.Peer-Reviewed Original ResearchConceptsRigorous mathematical proofGenetic data analysisReal data analysisUnbiased estimation methodEstimation methodIndividual-level genotype dataSample correlation coefficientMathematical proofMathematical derivationMean square errorCoefficient estimationMatrix methodEstimation accuracyEstimation biasHeritability estimationRoot mean square errorData analysisSquare errorAccurate estimatesEstimationUKINVariances of genotypesSpurious associationsKinship coefficientsEstimatesphyloMDA: an R package for phylogeny-aware microbiome data analysis
Liu T, Zhou C, Wang H, Zhao H, Wang T. phyloMDA: an R package for phylogeny-aware microbiome data analysis. BMC Bioinformatics 2022, 23: 213. PMID: 35668363, PMCID: PMC9169257, DOI: 10.1186/s12859-022-04744-5.Peer-Reviewed Original ResearchConceptsHost-associated microbial communitiesShared evolutionary historyMicrobiome data analysisEvolutionary historyPhylogenetic informationPhylogenetic treeMicrobial communitiesR packageSequencing technologiesAbundance dataMicrobial compositionRelative abundanceMicrobiome dataSample sitesUser-friendly toolMultivariate abundance dataAbundanceUnique opportunityUnprecedented scaleDifferent patternsTrees
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply