2025
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Wang J, Liu Y, Li H, Nguyen T, Soto-Vargas J, Wilson R, Wang W, Lam T, Zhang C, Lin C, Lewis D, Glausier J, Holtzheimer P, Friedman M, Williams K, Picciotto M, Nairn A, Krystal J, Duman R, Young K, Zhao H, Girgenti M. A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Medicine 2025, 17: 43. PMID: 40301990, PMCID: PMC12042318, DOI: 10.1186/s13073-025-01473-1.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderDorsolateral prefrontal cortexPsychiatric disordersAutism spectrum disorderPrefrontal cortexDepressive disorderStress disorderGamma-aminobutyric acidGenome-wide association studiesPTSD brainsGenome-wide measurementsStudies of postmortem brainsSubgenual prefrontal cortexDisabling psychiatric disorderMultiple psychiatric disordersPrefrontal cortical areasPTSD casesHuman brain studiesBrain regionsSpectrum disorderGABAergic processesPostmortem brainsMDDProtein co-expression modulesProteomic profiling
2023
Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Ruan P, Todd J, Zhao H, Liu Y, Vinisko R, Soellner J, Schmid R, Kaner R, Luckhardt T, Neely M, Noth I, Porteous M, Raj R, Safdar Z, Strek M, Hesslinger C, Palmer S, Leonard T, Salisbury M. Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression. Respiratory Research 2023, 24: 141. PMID: 37344825, PMCID: PMC10283254, DOI: 10.1186/s12931-023-02435-0.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionFemaleHumansIdiopathic Pulmonary FibrosisLungMaleMicroRNAsMultiomicsProteomicsConceptsComposite physiologic indexProgression-free survivalTransplant-free survivalMolecular subtypesSubtype 1Risk groupsProspective registrySubtype 2Disease progressionProspective registry of patientsIPF-PRO RegistryB-cell receptor signalingBackgroundIdiopathic pulmonary fibrosisRegistry of patientsCox proportional hazards modelsIntegrative multi-omics analysisAccumulation of extracellular matrixProportional hazards modelTransplant-freeProgression-FreeMolecular endotypesEnrichment of clinical trialsAntifibrotic treatmentMulti-omics analysisPulmonary fibrosis
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