2025
A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics
Cheng Z, Ren Y, Wang X, Zhang Y, Hua Y, Zhao H, Lu H. A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics. Briefings In Bioinformatics 2025, 26: bbaf216. PMID: 40381315, PMCID: PMC12085197, DOI: 10.1093/bib/bbaf216.Peer-Reviewed Original ResearchConceptsHepatocellular carcinoma patientsHepatocellular carcinomaHCC patientsPrognostic modelAdverse prognosisClinically relevant risk groupsRisk groupsTreatment of hepatocellular carcinomaTumor immune microenvironmentAlpha-fetoprotein levelsHigh-risk HCC patientsRelevant risk groupsPrognosis of HCC patientsHBV-infected hepatocellular carcinomaIron metabolismOverall survivalDifferential expression patternsDistant metastasisImmune microenvironmentTumor sizeLiver cancer progressionTumor differentiationMicrovascular invasionPredictive nomogramValidation cohort
2022
Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood
Qian D, Ulrich B, Peng G, Zhao H, Conneely K, Miller A, Bruner D, Eldridge R, Wommack E, Higgins K, Shin D, Saba N, Smith A, Burtness B, Park H, Stokes W, Beitler J, Xiao C. Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood. International Journal Of Radiation Oncology • Biology • Physics 2022, 115: 1217-1228. PMID: 36410685, PMCID: PMC12272450, DOI: 10.1016/j.ijrobp.2022.11.009.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Squamous CellDNA MethylationHead and Neck NeoplasmsHumansPrognosisSquamous Cell Carcinoma of Head and NeckConceptsRecurrence-free survivalWorse recurrence-free survivalOverall survivalMethylation risk scoreRadiation therapyValidation cohortPeripheral bloodDiscovery cohortOutcome stratificationShorter recurrence-free survivalNeck squamous cell carcinomaGastrostomy tube insertionHigher neutrophil countOral cavity cancerAforementioned risk factorsSquamous cell carcinomaPeripheral blood samplesNonmetastatic HNSCCNeutrophil countPrognostic factorsCox regressionPrognostic valueCell carcinomaTube insertionImmune modulation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply