2025
Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk
Hu J, Ye Y, Zhang C, Ruan Y, Natarajan P, Zhao H. Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk. PLOS Computational Biology 2025, 21: e1013191. PMID: 40570042, PMCID: PMC12212871, DOI: 10.1371/journal.pcbi.1013191.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresCAD-PRSUK BiobankCoronary artery disease polygenic risk scoreSummary-level dataCAD-related traitsSamples of European ancestryCoronary artery diseaseHigh-risk individualsPotential genetic heterogeneityCurrent smokingPolygenic scoresPolygenic riskTargeted interventionsEuropean ancestryRisk scorePleiotropic regionsRisk predictionGenetic heterogeneityBiological functionsPleiotropySignificant interactionPhenotypic heterogeneityBlood pressureDisease interpretationUnraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program
Pathak G, Koller D, Cabrera-Mendoza B, Djotsa A, Wendt F, De Lillo A, Friligkou E, He J, Kouakou M, Duong L, Vahey J, Steele L, Quaden R, Harrington K, Ahmed S, Gaziano J, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R, Program O. Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Human Molecular Genetics 2025, ddaf075. PMID: 40366759, DOI: 10.1093/hmg/ddaf075.Peer-Reviewed Original ResearchPolygenic scoresGulf War IllnessGenome-wide dataDepression polygenic scoresPhenome-wide analysisDiverse ancestral backgroundsT2D polygenic scoreAssociated with higher oddsGulf War eraPolygenic architectureAncestral backgroundVeteran ProgramChronic conditionsHigher oddsType 2 diabetesGW veteransVeteransDisease pathogenesisDiverse participantsGulf WarOddsPhysical strengthIllnessComprehensive assessmentAnxiety
2024
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
Bigdeli T, Barr P, Rajeevan N, Graham D, Li Y, Meyers J, Gorman B, Peterson R, Sayward F, Radhakrishnan K, Natarajan S, Nielsen D, Wilkinson A, Malhotra A, Zhao H, Brophy M, Shi Y, O’Leary T, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano J, Huang G, Concato J, Siever L, DeLisi L, Kimbrel N, Beckham J, Swann A, Kosten T, Fanous A, Aslan M, Harvey P. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular Psychiatry 2024, 29: 2399-2407. PMID: 38491344, DOI: 10.1038/s41380-024-02472-1.Peer-Reviewed Original ResearchBipolar I disorderSuicidal behaviorElectronic health recordsPolygenic scoresVeterans Health AdministrationSelf-reported SBColumbia-Suicide Severity Rating ScaleBipolar I disorder patientsCorrelates of suicidal behaviorClasses of psychotropic medicationsSelf-injurious behaviorHealth recordsSeverity Rating ScaleDiagnosed mental illnessAssociated with clinical variablesElectronic health record codesEHR domainDepressive disorderC-SSRSLifetime diagnosisSubstance-relatedPsychotropic medicationsSuicidal ideationExternalizing behaviorsSuicide attemptsEvaluating and improving health equity and fairness of polygenic scores
Zhang T, Zhou G, Klei L, Liu P, Chouldechova A, Zhao H, Roeder K, G’Sell M, Devlin B. Evaluating and improving health equity and fairness of polygenic scores. Human Genetics And Genomics Advances 2024, 5: 100280. PMID: 38402414, PMCID: PMC10937319, DOI: 10.1016/j.xhgg.2024.100280.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic scoring methodsPolygenic scoresGWAS informationGenome-wide association study single-nucleotide polymorphismsAnalysis of UK Biobank dataUK Biobank dataNon-European ancestryEstimation of linkage disequilibriumDiversity of human populationsHealth equitySingle-nucleotide polymorphismsBiobank dataAssociation statisticsLassosumPredictors of phenotypeAssociation studiesLinkage disequilibriumPhenotypic valuesSelective advantageClinical settingAncestryHuman heightScoresDisease status
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