Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations
Zhou G, Yolou I, Xie Y, Zhao H. Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations. American Journal Of Human Genetics 2025, 112: 1923-1935. PMID: 40633541, PMCID: PMC12252582, DOI: 10.1016/j.ajhg.2025.06.010.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresAdmixed individualsNon-European populationsLocal ancestryTransferability of PRSPerformance of polygenic risk scoresAdmixed populationsCross-ancestryPolygenic risk score calculatorGenetic prediction of complex traitsGenetic predictionEffect sizePrediction of complex traitsPopulation ArchitectureUK BiobankPolygenic predictionAdmixed AmericansAncestry clustersGenetic architectureComplex traitsPRS modelRisk scoreGenetic variantsAncestryIndividualsIncorporating local ancestry information to predict genetically associated DNA methylation in admixed populations
Cheng Y, Zhou G, Li H, Zhang X, Justice A, Martinez C, Aouizerat B, Xu K, Zhao H. Incorporating local ancestry information to predict genetically associated DNA methylation in admixed populations. Briefings In Bioinformatics 2025, 26: bbaf325. PMID: 40622482, PMCID: PMC12232425, DOI: 10.1093/bib/bbaf325.Peer-Reviewed Original ResearchConceptsMethylome-wide association studiesAdmixed populationsComplex traitsLocal ancestryAssociation studiesDNA methylationAssociated with complex traitsLocal ancestry informationPopulations of European ancestryCpG methylation levelsNon-European populationsMeasurement of methylationAncestry informationCpG sitesMethylation levelsEuropean ancestryEpigenetic underpinningsCpGAncestryTraitsMethylationAmerican populationAfrican American populationDNAPopulation
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