2025
High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties
Zhang J, Rajendran B, Desai S, Gibson J, DiPalermo J, LoRusso P, Kong Y, Zhao H, Cecchini M, Schalper K. High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties. Journal For ImmunoTherapy Of Cancer 2025, 13: e011653. PMID: 40935566, DOI: 10.1136/jitc-2025-011653.Peer-Reviewed Original ResearchThis study shows that high MGMT expression in colorectal cancer is linked to aggressive behavior, distinct genomic features, immune evasion, and shorter survival, highlighting its potential as a biomarker for prognosis and therapeutic targeting.
2023
Objective Analysis and Clinical Significance of the Spatial Tumor-Infiltrating Lymphocyte Patterns in Non-Small Cell Lung Cancer.
Lopez De Rodas M, Wang Y, Peng G, Gu J, Mino-Kenudson M, Riess J, Velcheti V, Hellmann M, Gainor J, Zhao H, Schalper K. Objective Analysis and Clinical Significance of the Spatial Tumor-Infiltrating Lymphocyte Patterns in Non-Small Cell Lung Cancer. Clinical Cancer Research 2023, 30: 998-1008. PMID: 38127300, PMCID: PMC10922461, DOI: 10.1158/1078-0432.ccr-23-2457.Peer-Reviewed Original ResearchNon-small cell lung cancerTIL subsetsCell lung cancerImmune evasion mechanismsSubset of casesLymphocyte infiltration patternsPathology-based approachStrong biomarker potentialTIL markersNSCLC patientsImmunotherapy outcomesLymphocyte patternsLung cancerTumor bedWorse outcomesClinical significanceMost tumorsEvasion mechanismsStromal tissueTumor samplesMultiplexed immunofluorescenceBiomarker potentialTumorsInfiltration patternsImmunotherapyCARE as a wearable derived feature linking circadian amplitude to human cognitive functions
Cui S, Lin Q, Gui Y, Zhang Y, Lu H, Zhao H, Wang X, Li X, Jiang F. CARE as a wearable derived feature linking circadian amplitude to human cognitive functions. Npj Digital Medicine 2023, 6: 123. PMID: 37433859, PMCID: PMC10336141, DOI: 10.1038/s41746-023-00865-0.Peer-Reviewed Original ResearchCognitive functionMendelian randomization analysisGenome-wide association studiesCausal effectsRandomization analysisPotential intervention strategiesAssociation studiesIntervention strategiesProspective memoryCircadian amplitudeHealthy participantsShort-term memoryGlobal Executive CompositeInstrumental variablesReasoning abilityGenetic lociActivity dataPineal hormone melatoninHuman cognitive functionsGenetic basisCircadian rhythmClinical significanceExecutive CompositeMendelianBehavioral processes
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