2025
JointPRS: A data-adaptive framework for multi-population genetic risk prediction incorporating genetic correlation
Xu L, Zhou G, Jiang W, Zhang H, Dong Y, Guan L, Zhao H. JointPRS: A data-adaptive framework for multi-population genetic risk prediction incorporating genetic correlation. Nature Communications 2025, 16: 3841. PMID: 40268942, PMCID: PMC12019179, DOI: 10.1038/s41467-025-59243-x.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenetic risk predictionUK BiobankGenome-wide association study summary statisticsAdmixed American populationsRisk predictionGenetic correlationsNon-European populationsContinental populationsAssociation studiesReal-data applicationBinary traitsTrait predictionSummary statisticsMultiple populationsAmerican populationData-adaptive approachSample sizeData applicationsAOUPopulationBiobankData scenarioTraitsA Bayesian approach to correcting the attenuation bias of regression using polygenic risk score
Zhou G, Qie X, Zhao H. A Bayesian approach to correcting the attenuation bias of regression using polygenic risk score. Genetics 2025, 229: iyaf018. PMID: 39891671, PMCID: PMC12168083, DOI: 10.1093/genetics/iyaf018.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresRisk scoreEstimation of regression coefficientsBayesian approachMeasurement error modelEstimation of coefficientsCoverage probabilityBayesian measurement error modelsAttenuation biasCredible intervalsCoefficient estimatesUK BiobankLogistic regressionMeasurement errorRegression coefficientsRegression modelsComplex traitsRegression analysisScoresEstimationError modelRegressionBiobankErrorCovariates
2024
Leveraging Functional Annotations Improves Cross-Population Genetic Risk Prediction
Ye Y, Xu L, Zhao H. Leveraging Functional Annotations Improves Cross-Population Genetic Risk Prediction. ICSA Book Series In Statistics 2024, 453-471. DOI: 10.1007/978-3-031-50690-1_18.Peer-Reviewed Original ResearchPolygenic risk scoresFunctional annotationGenetic risk predictionStandard PRSPost-GWAS analysisPolygenic risk score modelCross-population predictionNon-European populationsGenetic resultsGenetic studiesRisk predictionCross populationsAnnoPredPRS methodsUK BiobankAnnotationRisk scoreTraits/diseasesLDpredPopulationP+TPoor transferBiobankBayesian framework
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