2025
A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics
Cheng Z, Ren Y, Wang X, Zhang Y, Hua Y, Zhao H, Lu H. A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics. Briefings In Bioinformatics 2025, 26: bbaf216. PMID: 40381315, PMCID: PMC12085197, DOI: 10.1093/bib/bbaf216.Peer-Reviewed Original ResearchConceptsHepatocellular carcinoma patientsHepatocellular carcinomaHCC patientsPrognostic modelAdverse prognosisClinically relevant risk groupsRisk groupsTreatment of hepatocellular carcinomaTumor immune microenvironmentAlpha-fetoprotein levelsHigh-risk HCC patientsRelevant risk groupsPrognosis of HCC patientsHBV-infected hepatocellular carcinomaIron metabolismOverall survivalDifferential expression patternsDistant metastasisImmune microenvironmentTumor sizeLiver cancer progressionTumor differentiationMicrovascular invasionPredictive nomogramValidation cohort
2023
Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Ruan P, Todd J, Zhao H, Liu Y, Vinisko R, Soellner J, Schmid R, Kaner R, Luckhardt T, Neely M, Noth I, Porteous M, Raj R, Safdar Z, Strek M, Hesslinger C, Palmer S, Leonard T, Salisbury M. Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression. Respiratory Research 2023, 24: 141. PMID: 37344825, PMCID: PMC10283254, DOI: 10.1186/s12931-023-02435-0.Peer-Reviewed Original ResearchConceptsComposite physiologic indexProgression-free survivalTransplant-free survivalMolecular subtypesSubtype 1Risk groupsProspective registrySubtype 2Disease progressionProspective registry of patientsIPF-PRO RegistryB-cell receptor signalingBackgroundIdiopathic pulmonary fibrosisRegistry of patientsCox proportional hazards modelsIntegrative multi-omics analysisAccumulation of extracellular matrixProportional hazards modelTransplant-freeProgression-FreeMolecular endotypesEnrichment of clinical trialsAntifibrotic treatmentMulti-omics analysisPulmonary fibrosis
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