2025
Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma
Xiang X, Shetty K, Yu H, Mishra B, Wong L, Zhou X, Satapathy S, Crawford J, Latham P, Han S, Mathew B, Dagher N, Lau L, Cacaj F, Vegesna A, Dasarathy S, He A, Huang H, Amdur R, Mishra L. Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma. Liver International 2025, 45: e70325. PMID: 40919824, PMCID: PMC12416123, DOI: 10.1111/liv.70325.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, HepatocellularCross-Sectional StudiesFemaleHumansLiver CirrhosisLiver NeoplasmsLogistic ModelsLongitudinal StudiesMaleMiddle AgedProspective StudiesProteomicsReceptor, Transforming Growth Factor-beta Type IIRisk AssessmentRisk FactorsTransforming Growth Factor betaConceptsRisk of hepatocellular carcinomaHepatocellular carcinomaCohort ALogistic regression analysisCohort CLongitudinal follow-up analysisTGF-bHepatocellular carcinoma riskCancer-related deathsProtein signaturesSix-protein panelSerum proteomic profilesLate-stage diagnosisAFP levelsCirrhotic patientsCohort BMulticenter studyLogistic regression analyses of cross-sectional dataClinical factorsMultivariable prediction modelEarly diagnosisMatched subgroupsPatientsCirrhosisFunction biomarkers
2022
Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis
Bhowmick K, Amdur R, Xiang X, Yu H, Wong L, Rao S, He A, Amin K, Zaheer D, Narayan R, Satapathy S, Guha C, Latham P, Shetty K, Gough N, Mishra L. Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis. Cancer Research 2022, 82: 3379-3379. DOI: 10.1158/1538-7445.am2022-3379.Peer-Reviewed Original ResearchHepatocellular carcinomaLiver biopsyCirrhotic tissueStaining intensityAmerican Association for Cancer Research annual meetingsLogistic regression modelsDetection of hepatocellular carcinomaDiagnostic of hepatocellular carcinomaEarly detection of hepatocellular carcinomaMulti-cohort studyEvaluating biopsy samplesAnalysis of biopsy tissueAssociated with hepatocellular carcinomaTransforming growth factor-bDevelopment of hepatocellular carcinomaIndependent patient cohortHigh-risk groupGrowth factor BQuantitative IHCPatient cohortBiopsy tissueBiopsy samplesClinical trialsCirrhosisLoss of function
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