2024
Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location
WALTER J, BARNHART K, KOELPER N, SANTORO N, ZHANG H, THOMAS T, HUANG H, HARVIE H, Network E. Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location. American Journal Of Obstetrics And Gynecology 2024, 231: 328.e1-328.e11. PMID: 38552817, DOI: 10.1016/j.ajog.2024.03.035.Peer-Reviewed Original ResearchQuality-adjusted life yearsTwo-dose methotrexateUterine evacuationExpectant managementIncremental cost-effectiveness ratioPersistent pregnancyCost-effectiveness ratioSurgical managementCost-effectiveness acceptability curvesPersistent pregnancy of unknown locationLife yearsLower-risk patient populationsSerum human chorionic gonadotropinPregnancies of unknown locationLaparoscopic surgical managementRate of salpingectomyManagement of pregnancyMean quality-adjusted life yearsMulticenter randomized trialRisk patient populationLower mean costsCosts of surgical interventionsHuman chorionic gonadotropinLower quality-adjusted life yearsAcceptability curves
2020
OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial
Legro R, Hansen K, Diamond M, Steiner A, Mersereau J, Sarwer D, Kris-Etherton P, Wild R, Krawetz S, Hoeger K, Usadi R, Johnstone E, Hao H, Eisenberg E, Santoro N, Zhang H. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial. Journal Of The Endocrine Society 2020, 4: or11-04. PMCID: PMC7209215, DOI: 10.1210/jendso/bvaa046.2149.Peer-Reviewed Original ResearchStandard lifestyle modificationBetter birth outcomesUnexplained infertilityLive birthsObese womenBirth outcomesPregnancy lossLifestyle modificationLifestyle interventionWeight lossPhysical activityIL groupLow perinatal morbidityMajor pregnancy complicationsPreconception lifestyle interventionStandard lifestyle interventionGI side effectsKey secondary outcomesMulticenter randomized trialUse of orlistatMajor congenital anomaliesModerate weight lossPregnancy complication rateEarly pregnancy lossGestational DM
2018
The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory Women
Wei D, Yu Y, Sun M, Shi Y, Sun Y, Deng X, Li J, Wang Z, Zhao S, Zhang H, Legro RS, Chen ZJ. The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory Women. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2735-2742. PMID: 29718297, DOI: 10.1210/jc.2018-00613.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFrozen embryo transferFresh embryo transferLive birth rateOvulatory womenOvarian stimulationEmbryo transferSupraphysiological estradiolPregnancy outcomesEstradiol levelsBirth ratePeak estradiol levelsMulticenter randomized trialSimilar study designPCOS womenOvary syndromeOvarian responsePrimary outcomeRandomized trialsEstradiol exposureLive birthsMAIN OUTCOMEEmbryo implantationPg/Secondary analysis
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