2025
S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators
Ding S, Liu R, Srivastava A, Nowakowski R, Shen L, Thompson P, Zhang H, Huang C. S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators. Human Brain Mapping 2025, 46: e70297. PMID: 40741986, PMCID: PMC12311987, DOI: 10.1002/hbm.70297.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsMediation analysisGenetic exposuresPotential genetic variantsMediation analysis frameworkBrain imaging phenotypesSignificant mediation effectGenetic variantsGenetic effectsSubcortical shapeAlzheimer's Disease Neuroimaging InitiativeMediation effectSquare-root velocity function representationBrainIndirect effectsNeurological pathwaysClinical outcomesPathwayImaging phenotypesHilbert spaceHilbert subspaceStatistical inferenceMediators
2018
Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort
Wen C, Mehta CM, Tan H, Zhang H. Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort. Genetic Epidemiology 2018, 42: 265-275. PMID: 29411414, PMCID: PMC5851842, DOI: 10.1002/gepi.22111.Peer-Reviewed Original ResearchConceptsGenetic markersGenome-wide association study datasetWhole-genome association studiesComplex genetic basisGenome association studiesBrain-wide imaging phenotypesMultivariate phenotypesGenetic basisAssociation studiesGenetic studiesNeuropsychological disordersClinical diagnostic criteriaCovariance testBiological basisPhenotypeDiagnostic criteriaNeuroimaging biomarkersBrain functionBrain structuresPediatric imagingGWASImaging phenotypesDiffusion tensor
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply