S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators
Ding S, Liu R, Srivastava A, Nowakowski R, Shen L, Thompson P, Zhang H, Huang C. S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators. Human Brain Mapping 2025, 46: e70297. PMID: 40741986, PMCID: PMC12311987, DOI: 10.1002/hbm.70297.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsMediation analysisGenetic exposuresPotential genetic variantsMediation analysis frameworkBrain imaging phenotypesSignificant mediation effectGenetic variantsGenetic effectsSubcortical shapeAlzheimer's Disease Neuroimaging InitiativeMediation effectSquare-root velocity function representationBrainIndirect effectsNeurological pathwaysClinical outcomesPathwayImaging phenotypesHilbert spaceHilbert subspaceStatistical inferenceMediatorsSex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-SpecificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of life
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