2025
Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activity
2003
A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse
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