2025
A Relook at the Relevance of Thyroid Stimulating Hormone and Thyroid Autoimmunity for Pregnancy Outcomes: Analyses of Randomized Control Trials Data From Pregnancy and Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
Kuokkanen S, Seungdamrong A, Santoro N, Lieman H, Sun F, Wild R, Zhang H, Pal L. A Relook at the Relevance of Thyroid Stimulating Hormone and Thyroid Autoimmunity for Pregnancy Outcomes: Analyses of Randomized Control Trials Data From Pregnancy and Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Obstetrical & Gynecological Survey 2025, 80: 561-562. DOI: 10.1097/ogx.0000000000001445.Peer-Reviewed Original ResearchPreterm deliveryThyroid autoimmunityAssessment of Multiple Intrauterine GestationsAssociated with pregnancy complicationsLow birth weightThyroid-stimulating hormonePolycystic ovary syndromeIntrauterine gestationPregnancy complicationsPregnancy outcomesOvarian stimulationBirth weightStimulating hormonePregnancy lossPregnancyAssociated with negative outcomesPretermHypothyroidismAutoimmunityThyroidTrial dataOutcomesDeliveryGestationComplicationsPhysician Use of Large Language Models: A Quantitative Study Based on Large-Scale Query-Level Data
Qiu L, Tang C, Bi X, Burtch G, Chen Y, Zhang H. Physician Use of Large Language Models: A Quantitative Study Based on Large-Scale Query-Level Data. Journal Of Medical Internet Research 2025, 27: e76941. PMID: 40854236, PMCID: PMC12377787, DOI: 10.2196/76941.Peer-Reviewed Original ResearchConceptsSensitive informationPresence of sensitive informationRisk of privacy breachesPhysician usePrivacy breach riskPhysician queriesPhysician demographicsPhysician interactionUsage patternsClinical questionsProportion of clinical questionsQuery levelGenerative artificial intelligencePrivacy breachesSensitive classifiersLanguage modelMobile devicesUse casesQueryResearch workflowArtificial intelligencePatient privacyBreach riskPhysician engagementMedical technology departmentsS‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators
Ding S, Liu R, Srivastava A, Nowakowski R, Shen L, Thompson P, Zhang H, Huang C. S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators. Human Brain Mapping 2025, 46: e70297. PMID: 40741986, PMCID: PMC12311987, DOI: 10.1002/hbm.70297.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsMediation analysisGenetic exposuresPotential genetic variantsMediation analysis frameworkBrain imaging phenotypesSignificant mediation effectGenetic variantsGenetic effectsSubcortical shapeAlzheimer's Disease Neuroimaging InitiativeMediation effectSquare-root velocity function representationBrainIndirect effectsNeurological pathwaysClinical outcomesPathwayImaging phenotypesHilbert spaceHilbert subspaceStatistical inferenceMediatorsA Unified Framework for Residual Diagnostics in Generalized Linear Models and Beyond
Liu D, Lin Z, Zhang H. A Unified Framework for Residual Diagnostics in Generalized Linear Models and Beyond. Journal Of The American Statistical Association 2025, ahead-of-print: 1-13. DOI: 10.1080/01621459.2025.2504037.Peer-Reviewed Original ResearchEfficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial
Deng S, Zhao Z, Feng L, Huang X, Wang S, Xue X, Yan L, Ma B, Hao L, Li X, Yang L, Si M, Zhang H, Chen Z, Zhu L. Efficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial. Chinese Medical Journal 2025, 138: 985-987. PMID: 40143426, PMCID: PMC12037080, DOI: 10.1097/cm9.0000000000003473.Peer-Reviewed Original ResearchEvaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson J, Siblini H, Al‐Hendy A, Segars J, González F, Taylor H, Singh B, Carson S, Christman G, Huang H, Dangi B, Zhang H. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. Clinical And Translational Science 2025, 18: e70189. PMID: 40077973, PMCID: PMC11903501, DOI: 10.1111/cts.70189.Peer-Reviewed Original ResearchConceptsEpigallocatechin-3-gallateFolate levelsUterine fibroidsClinical trialsGreen tea extractAssociated with folate deficiencyPresence of MTHFRWomen of Childbearing AgeSerum folate levelsReduced folate levelsActive clinical trialsReproductive-age womenEffect of epigallocatechin gallateDHFR genotypeDHFR polymorphismTea extractDaily doseClomiphene citrateUnexplained infertilityFolate deficiencyChildbearing ageClinical studiesTreated womenFibroidsLetrozoleIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. PMID: 40958822, PMCID: PMC12435467, DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activitySex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-SpecificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of lifeEmpowering genome-wide association studies via a visualizable test based on the regional association score
Jiang Y, Zhang H. Empowering genome-wide association studies via a visualizable test based on the regional association score. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419721122. PMID: 39999171, PMCID: PMC11892588, DOI: 10.1073/pnas.2419721122.Peer-Reviewed Original Research
2024
A relook at the relevance of thyroid stimulating hormone and thyroid autoimmunity for pregnancy outcomes: Analyses of randomized control trials data from Pregnancy in Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation
Kuokkanen S, Seungdamrong A, Santoro N, Lieman H, Sun F, Wild R, Zhang H, Pal L. A relook at the relevance of thyroid stimulating hormone and thyroid autoimmunity for pregnancy outcomes: Analyses of randomized control trials data from Pregnancy in Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation. Fertility And Sterility 2024, 123: 873-882. PMID: 39672366, PMCID: PMC12045735, DOI: 10.1016/j.fertnstert.2024.12.005.Peer-Reviewed Original ResearchThyroid-stimulating hormoneRandomized Controlled TrialsTPO-AbThyroid autoimmunityPregnancy outcomesAssessment of Multiple Intrauterine GestationsRetrospective cohort analysis of dataRisk of pregnancy lossEarly preterm birthMaternal TSH levelsThyroid peroxidase antibodyCohort analysis of dataRetrospective cohort analysisBody mass indexDuration of infertilityAnalysis of RCT dataPolycystic ovary syndromeIntrauterine gestationPreterm birthTSH levelsPeroxidase antibodiesOvarian stimulationLive birthsPPCOS IIStimulating hormoneHeritability and genetic contribution analysis of structural-functional coupling in human brain
Dai W, Zhang Z, Song P, Zhang H, Zhao Y. Heritability and genetic contribution analysis of structural-functional coupling in human brain. Imaging Neuroscience 2024, 2: imag-2-00346. PMID: 40800503, PMCID: PMC12290780, DOI: 10.1162/imag_a_00346.Peer-Reviewed Original ResearchSC-FCSC-FC couplingStructural connectivityHuman Connectome ProjectConnectome ProjectVisual cortexCouplingFunctional connectivityWhite matter structural connectivityCingulo-opercularDorsal attentionGenetic correlation analysisSpectrum of complex traitsAdolescent Brain Cognitive Development StudyFunctional networksComplex traitsGenetic lociCognitive Development StudyGenetic variationGenetic interplayMode networkStructural-functional couplingSpectraCOVINet: a deep learning-based and interpretable prediction model for the county-wise trajectories of COVID-19 in the United States
Jiang Y, Tian T, Zhou W, Zhang Y, Li Z, Wang X, Zhang H. COVINet: a deep learning-based and interpretable prediction model for the county-wise trajectories of COVID-19 in the United States. Journal Of Applied Statistics 2024, 52: 1063-1080. PMID: 40160484, PMCID: PMC11951337, DOI: 10.1080/02664763.2024.2412284.Peer-Reviewed Original ResearchIS HISTORY OF POLYCYSTIC OVARY SYNDROME (PCOS) RELATED TO SLEEP QUALITY IN POSTMENOPAUSAL WOMEN IN THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION
Alur-Gupta S, Sun F, Zhang H, Derby C, Kravitz H, Neal-Perry G, Swanson L, Vitek W, Santoro N, Sammel M. IS HISTORY OF POLYCYSTIC OVARY SYNDROME (PCOS) RELATED TO SLEEP QUALITY IN POSTMENOPAUSAL WOMEN IN THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION. Fertility And Sterility 2024, 122: e419. DOI: 10.1016/j.fertnstert.2024.08.262.Peer-Reviewed Original ResearchEffect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial
Ma X, Wang J, Shi Y, Tan J, Guan Y, Sun Y, Zhang B, Zhao J, Liu J, Cao Y, Li H, Zhang C, Chen F, Yi H, Wang Z, Xin X, Kong P, Lu Y, Huang L, Yuan Y, Liu H, Li C, Mol B, Hu Z, Zhang H, Chen Z, Liu J. Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial. Nature Communications 2024, 15: 7747. PMID: 39237545, PMCID: PMC11377718, DOI: 10.1038/s41467-024-52008-y.Peer-Reviewed Original ResearchConceptsLive birth rateIn vitro fertilizationCumulative live birth rateCumulative live birthBlastocyst transferBlastocyst-stageCleavage-stageEmbryo transferLive birthsHigher preterm birth rateBlastocyst-stage groupBlastocyst-stage transferCleavage-stage groupCleavage-stage transferPreterm birth rateYear of randomizationMulticenter randomized controlled trialPrognosis womenRandomized Controlled TrialsPregnancy outcomesCounseling patientsRandomized trialsNon-inferiorityPrimary outcomeSecondary outcomesAN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.
Dai W, Zhang H. AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY. The Annals Of Applied Statistics 2024, 18: 2277-2294. PMID: 39640845, PMCID: PMC11616023, DOI: 10.1214/24-aoas1880.Peer-Reviewed Original ResearchGenetic variantsFunctional connectivityEffects of multiple genetic variantsMediation modelBehavioral outcomesEffects of genetic variantsMultiple genetic variantsCumulative genetic effectsFluid intelligenceUnivariate mediatorImpact of geneticsCognitive behaviorVisual networkGenetic effectsNeural circuitsNetwork mediatorsFunctional networksYoung adultsVariantsVariant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDiseaseThe effect of improved metabolic syndrome parameters on live birth
Spitzer T, Diamond M, Wild R, Legro R, Zhang H, Sun F, Ling S, Santoro N. The effect of improved metabolic syndrome parameters on live birth. Fertility And Sterility 2024, 122: 373-375. PMID: 38641159, DOI: 10.1016/j.fertnstert.2024.04.020.Peer-Reviewed Original ResearchMetabolic syndrome Z-scoreLifestyle interventionLive birthsLive birth rateMetabolic syndrome parametersZ-scoreMetabolic syndromeUnexplained infertilityIntrauterine inseminationOvarian stimulationSyndrome parametersMetabolic parametersObese womenBirth outcomesLive birth outcomesIntervention phaseImprove metabolic syndromeSecondary analysisFisher's exact testStudy participantsZ-score differenceLifestyle modificationStudent's t-testBirth rateLogistic regressionTENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION.
Liu Z, Lee C, Zhang H. TENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION. The Annals Of Applied Statistics 2024, 18: 1294-1318. PMID: 38682044, PMCID: PMC11046526, DOI: 10.1214/23-aoas1835.Peer-Reviewed Original ResearchTensor trainCoefficient tensorRate of convergenceLow-rankQuantile regression frameworkApproximation-based methodVariation penaltyHuman intelligenceQuantile regression modelEstimation algorithmMRI image dataAsymptotic normalityArray of imagesScalar outcomeEmpirical performanceImage dataTrained estimatorDimensionalityNumerical studyMagnetic resonance imaging imagesQuantile regressionTensorRegression frameworkTT estimationImagesCost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location
WALTER J, BARNHART K, KOELPER N, SANTORO N, ZHANG H, THOMAS T, HUANG H, HARVIE H, Network E. Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location. American Journal Of Obstetrics And Gynecology 2024, 231: 328.e1-328.e11. PMID: 38552817, DOI: 10.1016/j.ajog.2024.03.035.Peer-Reviewed Original ResearchQuality-adjusted life yearsTwo-dose methotrexateUterine evacuationExpectant managementIncremental cost-effectiveness ratioPersistent pregnancyCost-effectiveness ratioSurgical managementCost-effectiveness acceptability curvesPersistent pregnancy of unknown locationLife yearsLower-risk patient populationsSerum human chorionic gonadotropinPregnancies of unknown locationLaparoscopic surgical managementRate of salpingectomyManagement of pregnancyMean quality-adjusted life yearsMulticenter randomized trialRisk patient populationLower mean costsCosts of surgical interventionsHuman chorionic gonadotropinLower quality-adjusted life yearsAcceptability curvesHeterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition
Wang S, Constable T, Zhang H, Zhao Y. Heterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition. Journal Of The American Statistical Association 2024, 119: 851-863. PMID: 39371422, PMCID: PMC11451334, DOI: 10.1080/01621459.2024.2311363.Peer-Reviewed Original Research
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