2024
Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial
Ma X, Wang J, Shi Y, Tan J, Guan Y, Sun Y, Zhang B, Zhao J, Liu J, Cao Y, Li H, Zhang C, Chen F, Yi H, Wang Z, Xin X, Kong P, Lu Y, Huang L, Yuan Y, Liu H, Li C, Mol B, Hu Z, Zhang H, Chen Z, Liu J. Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial. Nature Communications 2024, 15: 7747. PMID: 39237545, PMCID: PMC11377718, DOI: 10.1038/s41467-024-52008-y.Peer-Reviewed Original ResearchConceptsLive birth rateIn vitro fertilizationCumulative live birth rateCumulative live birthBlastocyst transferBlastocyst-stageCleavage-stageEmbryo transferLive birthsHigher preterm birth rateBlastocyst-stage groupBlastocyst-stage transferCleavage-stage groupCleavage-stage transferPreterm birth rateYear of randomizationMulticenter randomized controlled trialPrognosis womenRandomized controlled trialsPregnancy outcomesCounseling patientsRandomized trialsNon-inferiorityPrimary outcomeSecondary outcomes
2022
Live Birth With or Without Preimplantation Genetic Testing for Aneuploidy
Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro R, Chen Z. Live Birth With or Without Preimplantation Genetic Testing for Aneuploidy. Obstetrical & Gynecological Survey 2022, 77: 159-161. DOI: 10.1097/01.ogx.0000822436.67205.20.Peer-Reviewed Original ResearchPreimplantation genetic testingLive birth rateIn vitro fertilizationPGT-AGenetic testingWomen of advanced maternal ageIncreased live birth rateAdvanced maternal ageBirth experienceHigh quality embryosBirth rateMaternal ageQuality embryosLive birthsMorphology scorePreimplantationAneuploidyGenetic statusWomenPrognosisScoresBirth
2021
Live Birth with or without Preimplantation Genetic Testing for Aneuploidy
Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro R, Chen Z. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. New England Journal Of Medicine 2021, 385: 2047-2058. PMID: 34818479, DOI: 10.1056/nejmoa2103613.Peer-Reviewed Original ResearchConceptsConventional in vitro fertilizationCumulative live birth rateLive birth rateIn vitro fertilizationGood-quality blastocystsPGT-A groupPGT-APreimplantation genetic testingLive birthsGenetic testingClinical pregnancy lossImprove pregnancy outcomesInitial embryo transferEmbryo-transfer proceduresYears of ageNeonatal complicationsPregnancy outcomesSubfertile womenEmbryo transferAdverse eventsPregnancy lossNoninferiority marginEmbryo selectionPrimary outcomeBlastocyst
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