2025
Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-specificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of life
2020
Super‐variants identification for brain connectivity
Li T, Hu J, Wang S, Zhang H. Super‐variants identification for brain connectivity. Human Brain Mapping 2020, 42: 1304-1312. PMID: 33236465, PMCID: PMC7927294, DOI: 10.1002/hbm.25294.Peer-Reviewed Original ResearchConceptsCombination of allelesSingle nucleotide polymorphismsNovel lociBrain connectivityUK Biobank databaseChromosome 1Multiple lociGenetic effectsGenetic variantsNucleotide polymorphismsAssociation detectionLociGenetic associationGenesNeurodegenerative disordersBiobank databaseBrain issuesGenetic biomarkersBrain functionBrain structuresGenomeRSPO2Discovery phaseAssociationTMEM74
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