2025
Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush J, Krumholz H, Abaluck J. Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. JAMA Network Open 2025, 8: e2526013. PMID: 40779264, PMCID: PMC12334959, DOI: 10.1001/jamanetworkopen.2025.26013.Peer-Reviewed Original ResearchConceptsHealth care expendituresCardiovascular risk factorsCare expendituresCohort studyRisk factorsYale New Haven Health SystemCohort study of adultsType 2 diabetes statusLong-term impactStudy of adultsHealth systemRetrospective cohort studyBlood pressureHemoglobin A1c reductionMain OutcomesTotal cholesterolSentara HealthcareInpatient staySecondary outcomesGlucagon-like peptide-1 receptor agonistsPrimary outcomeHealthPeptide-1 receptor agonistsAssociated with clinical outcomesAssociated with reductionsFDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program
Kadakia K, Dhruva S, Ross J, Burke J, Johnston J, Ramachandran R, Krumholz H, Rathi V. FDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program. JAMA Internal Medicine 2025, 185: 996-1004. PMID: 40587167, PMCID: PMC12210143, DOI: 10.1001/jamainternmed.2025.2235.Peer-Reviewed Original ResearchConceptsFood and Drug AdministrationFDA review timesFood and Drug Administration authorityFood and Drug Administration dataShort follow-up durationUS Food and Drug AdministrationFollow-up durationDevice programmingEffectiveness end pointCross-sectional studyHigh-risk devicesSurrogate measureTarget timeframePostmarketing studiesMain OutcomesEnd pointsPatient accessDrug AdministrationHigh riskClass IStudy characteristicsTherapeutic devicesClinical testingSurrogate measures of effectivenessMeasures of effectivenessHypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Hypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic. Journal Of Clinical Hypertension 2025, 27: e70093. PMID: 40685707, PMCID: PMC12277530, DOI: 10.1111/jch.70093.Peer-Reviewed Original ResearchConceptsHypertension prevalencePrevalence ratiosUS adultsAge-standardized prevalence estimatesAggressive public health effortsPublic health effortsPre-pandemicControl of hypertensionCOVID-19 pandemicHypertension awarenessHealth effortsPoisson regressionImpact of hypertensionPost-pandemicPrevalence estimatesNHANES dataNationwide prevalenceCause of deathUnited StatesBlood pressure controlNational trendsPrevalenceCOVID-19AdultsHypertensionTrends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.Peer-Reviewed Original ResearchConceptsLife's Essential 8 scoreLife's Essential 8Cross-sectional studyWhite differencesEthnic differencesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySleep health scoreNutrition Examination SurveyGroup-specific interventionsPrimary positive factorPhysical activityExamination SurveyHealth scoresBlack adultsWhite adultsMain OutcomesAsian adultsOverall scoreEvaluate trendsNicotine exposureEssential 8Blood lipidsAdultsEthnic groups10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population
Faridi K, Malik D, Essa M, Yang H, Spatz E, Krumholz H, Lu Y. 10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population. Journal Of The American College Of Cardiology 2025, 85: 2239-2249. PMID: 40499978, DOI: 10.1016/j.jacc.2025.03.546.Peer-Reviewed Original ResearchConceptsRisk of cardiovascular diseaseAtherosclerotic CVDU.S. adultsU.S. populationHispanic adultsCardiovascular diseaseCVD riskLong-term riskNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRisk of atherosclerotic CVDElevated 10-year riskLong-term risk of cardiovascular diseaseAdults aged >Nutrition Examination SurveyTotal cardiovascular diseaseRisk factor profileRisk of total cardiovascular diseaseSurvey-weighted prevalenceMiddle-aged adultsPrevent Cardiovascular DiseaseHeart failureExamination SurveyAge-standardizedBlack adultsProphylactic Weekly Efanesoctocog Alfa Versus Standard-Care Factor VIII in People Living With Severe Hemophilia A : A Cost-Effectiveness Analysis.
Ito S, Potnis K, Harvey J, Sra M, Bewersdorf J, Bona R, Krumholz H, Cuker A, Pandya A, Goshua G. Prophylactic Weekly Efanesoctocog Alfa Versus Standard-Care Factor VIII in People Living With Severe Hemophilia A : A Cost-Effectiveness Analysis. Annals Of Internal Medicine 2025, 178: 819-828. PMID: 40258278, PMCID: PMC12170149, DOI: 10.7326/annals-24-02749.Peer-Reviewed Original ResearchConceptsEquity weightsSevere hemophilia AInequality aversion parameterFactor VIIIHemophilia AAversion parameterCost-effectiveness analysisEquity standardsCost-effectiveness of prophylaxisTime horizonOnce-weekly prophylaxisPriceAnnualized bleeding rateIncremental cost-effectiveness ratioFactor VIII prophylaxisScenario analysisCost-effectiveness ratioUnited StatesLifetime QALYsBleeding rateProphylaxisNational Institutes of HealthCost-effectiveInstitutes of HealthAlfaFloods and cause-specific mortality in the United States applying a triply robust approach
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States applying a triply robust approach. Nature Communications 2025, 16: 2853. PMID: 40122917, PMCID: PMC11930965, DOI: 10.1038/s41467-025-58236-0.Peer-Reviewed Original ResearchConceptsCDC's National Center for Health StatisticsNational Center for Health StatisticsCause-specific mortality ratesCenter for Health StatisticsCause-specific mortalityHealth impacts of floodingExcess all-cause deathsLong-term health risksFlood daysLong-term associationDeath recordsHealth StatisticsConfounder adjustmentExternal causesStorm Events DatabaseAll-cause deathHealth impactsImpact of floodsPropensity scorePost‐flood yearMortality rateMyocardial infarctionPost-floodContiguous U.S.Respiratory disease
2024
Hospital COVID-19 Burden and Adverse Event Rates
Metersky M, Rodrick D, Ho S, Galusha D, Timashenka A, Grace E, Marshall D, Eckenrode S, Krumholz H. Hospital COVID-19 Burden and Adverse Event Rates. JAMA Network Open 2024, 7: e2442936. PMID: 39495512, PMCID: PMC11581512, DOI: 10.1001/jamanetworkopen.2024.42936.Peer-Reviewed Original ResearchConceptsCOVID-19 burdenHospital admissionPatient safetyRelative riskCohort studyStudy of hospital admissionsAcute care hospitalsRisk-adjustment variablesRisk-adjusted ratesMedicare hospital admissionsCOVID-19 pandemicStaffing shortagesHospital characteristicsMain OutcomesHospital resilienceSurge capacityMedicare patientsCare hospitalHighest burdenPrevent declinesPatient admissionsStudy sampleElixhauser comorbiditiesCOVID-19Low burdenRacial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, PMCID: PMC11581672, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-Cause MortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent ageLong-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PMWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesUse of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks
Lu Y, Keeley E, Barrette E, Cooper-DeHoff R, Dhruva S, Gaffney J, Gamble G, Handke B, Huang C, Krumholz H, McDonough C, Schulz W, Shaw K, Smith M, Woodard J, Young P, Ervin K, Ross J. Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks. BMC Cardiovascular Disorders 2024, 24: 497. PMID: 39289597, PMCID: PMC11409735, DOI: 10.1186/s12872-024-04161-x.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsHealth systemUncontrolled hypertensionUse of electronic health recordsHypertension managementElectronic health record systemsOneFlorida Clinical Research ConsortiumElectronic health record dataYale New Haven Health SystemBP measurementsICD-10-CM codesHealth system networkPublic health priorityICD-10-CMIncidence rate of deathElevated BP measurementsElevated blood pressure measurementsHealthcare visitsAmbulatory careHealth priorityRetrospective cohort studyEHR dataOneFloridaBlood pressure measurementsCardiovascular Disease Risk Factor Control Following Release From Carceral Facilities: A Cross-Sectional Study.
Aminawung J, Puglisi L, Roy B, Horton N, Elumn J, Lin H, Bibbins-Domingo K, Krumholz H, Wang E. Cardiovascular Disease Risk Factor Control Following Release From Carceral Facilities: A Cross-Sectional Study. Journal Of The American Heart Association 2024, 13: ejaha2024035683t. PMID: 39248257, PMCID: PMC11935634, DOI: 10.1161/jaha.124.035683.Peer-Reviewed Original ResearchConceptsUncontrolled CVD risk factorsCardiovascular disease risk factor controlCVD risk factorsRisk factor controlFactor controlRisk factorsSocial determinant of cardiovascular healthCardiovascular diseaseProspective cohort study of individualsDeterminants of cardiovascular healthPublic health prevention effortsCardiovascular disease risk factorsCohort study of individualsHealth prevention effortsCross-sectional studyProspective cohort studyCarceral facilitiesCorrectional facilitiesSocial determinantsTailored interventionsTraditional risk factorsStudy of individualsAdversity scorePerceived stressCardiovascular healthCause-Specific Mortality Rates Among the US Black Population
Arun A, Caraballo C, Sawano M, Lu Y, Khera R, Yancy C, Krumholz H. Cause-Specific Mortality Rates Among the US Black Population. JAMA Network Open 2024, 7: e2436402. PMID: 39348122, PMCID: PMC11443349, DOI: 10.1001/jamanetworkopen.2024.36402.Commentaries, Editorials and LettersThe Integration of Clinical Trials With the Practice of Medicine
Angus D, Huang A, Lewis R, Abernethy A, Califf R, Landray M, Kass N, Bibbins-Domingo K, Abbasi A, Abebe K, Abernethy A, Adam S, Angus D, Ard J, Berkwits M, Bender Ignacio R, Berry S, Bhatt D, Bibbins-Domingo K, Bonow R, Bonten M, Brangman S, Brownstein J, Buntin M, Butte A, Califf R, Campbell M, Cappola A, Chiang A, Cook D, Cummings S, Curfman G, Esserman L, Fleisher L, Franklin J, Gonzalez R, Grossman C, Haddad T, Herbst R, Hernandez A, Holder D, Horn L, Huang G, Huang A, Kass N, Khera R, Koroshetz W, Krumholz H, Landray M, Lewis R, Lieu T, Malani P, Martin C, McClellan M, McDermott M, Morain S, Murphy S, Nicholls S, Nicholls S, O'Dwyer P, Patel B, Peterson E, Prindiville S, Ross J, Rowan K, Rubenfeld G, Seymour C, Taylor R, Waldstreicher J, Wang T. The Integration of Clinical Trials With the Practice of Medicine. JAMA 2024, 332: 153-162. PMID: 38829654, PMCID: PMC12045079, DOI: 10.1001/jama.2024.4088.Peer-Reviewed Original ResearchConceptsHealth care delivery enterpriseHealth care deliveryCare deliveryIntegrity of clinical trialsRandomized clinical trialsHealth careOptimal health care deliveryHealth care delivery systemCare delivery systemLearning health systemElectronic health recordsPractice of medicineHealth recordsImplementation scienceHealth systemHealth dataOptimal careQuality improvementCareNonfinancial incentivesVulnerable populationsPoor accessStudy designClinical trialsHealthIncorporating Medicare Advantage Admissions Into the CMS Hospital-Wide Readmission Measure
Kyanko K, Sahay K, Wang Y, Li S, Schreiber M, Hager M, Myers R, Johnson W, Zhang J, Krumholz H, Suter L, Triche E. Incorporating Medicare Advantage Admissions Into the CMS Hospital-Wide Readmission Measure. JAMA Network Open 2024, 7: e2414431. PMID: 38829614, PMCID: PMC11148674, DOI: 10.1001/jamanetworkopen.2024.14431.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesSpecialty subgroupsPerformance quintileMedicare AdvantageReadmission ratesRisk-standardized readmission ratesHospital-wide readmission measureHospital outcome measuresTest-retest reliabilityRisk-adjustment variablesMeasurement reliabilityAdministrative claims dataReadmission measuresImprove measurement reliabilityIntegrated Data RepositoryMA beneficiariesQuintile rankingsMedicare beneficiariesMedicaid ServicesAll-CausePublic reportingStudy assessed differencesClaims dataOutcome measuresMA cohortSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay
2023
Prevalence of covid-19 and long covid in collegiate student athletes from spring 2020 to fall 2021: a retrospective survey
Massey D, Saydah S, Adamson B, Lincoln A, Aukerman D, Berke E, Sikka R, Krumholz H. Prevalence of covid-19 and long covid in collegiate student athletes from spring 2020 to fall 2021: a retrospective survey. BMC Infectious Diseases 2023, 23: 876. PMID: 38093182, PMCID: PMC10717379, DOI: 10.1186/s12879-023-08801-z.Peer-Reviewed Original ResearchMeSH KeywordsAthletesCOVID-19HumansPost-Acute COVID-19 SyndromePrevalenceRetrospective StudiesSARS-CoV-2StudentsUnited StatesConceptsLong COVIDCOVID-19SARS-CoV-2 infectionPost-acute sequelaeSymptomatic COVID-19SARS-CoV-2Student athletesPost-COVID conditionsMental health consequencesHealthy athletesCollegiate Student-AthletesHealthy peopleRetrospective surveyMore weeksHealth consequencesPrevalenceConclusionsThis studyConvenience sampleFall 2020College athletesFurther studiesAthletesCOVIDSpring 2020Relevant time periodData Sharing — A New Era for Research Funded by the U.S. Government
Ross J, Waldstreicher J, Krumholz H. Data Sharing — A New Era for Research Funded by the U.S. Government. New England Journal Of Medicine 2023, 389: 2408-2410. PMID: 37966303, DOI: 10.1056/nejmp2308792.Peer-Reviewed Original ResearchRacial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrationsClinical trial data sharing: a cross-sectional study of outcomes associated with two U.S. National Institutes of Health models
Rowhani-Farid A, Grewal M, Solar S, Eghrari A, Zhang A, Gross C, Krumholz H, Ross J. Clinical trial data sharing: a cross-sectional study of outcomes associated with two U.S. National Institutes of Health models. Scientific Data 2023, 10: 529. PMID: 37553403, PMCID: PMC10409750, DOI: 10.1038/s41597-023-02436-0.Peer-Reviewed Original Research
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