2025
Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials
Ortega-Paz L, Talasaz A, Sadeghipour P, Rashedi S, Connors J, Angiolillo D, Cavallari L, Jimenez D, Bastidas G, Lorenzi E, Berry L, Hills T, McAuley D, Shah T, Lansky A, Deepti S, Gaitán-Duarte H, Potpara T, Galli M, Dixon D, Piazza G, Lip G, Mehran R, Libby P, Krumholz H, Bikdeli B. Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials. Thrombosis Research 2025, 255: 109484. PMID: 40992230, DOI: 10.1016/j.thromres.2025.109484.Peer-Reviewed Original ResearchRandomized Controlled TrialsStatin therapyCollaborative meta-analysisHospitalized patientsClinical impactImpact of statin therapyMeta-analysis of randomized controlled trialsCo-treatmentLiver enzyme abnormalitiesExcellent safety profileEffects of statinsCOVID-19 patientsNo significant differenceSafety profileEnzyme abnormalitiesLiver enzymesStatinsSafety outcomesTherapyPatientsCOVID-19 outcomesDisease severitySignificant differenceRandomized participantsSystematic reviewA Multifaceted Intervention to Mitigate the Adverse Cardiovascular Effects of Air Pollution: A Feasibility Randomized Controlled Trial
Sadeghipour P, Talasaz A, Rashedi S, Jamalkhani S, Ghoshouni H, Babaei M, Kohansal E, Mohebbi B, Elahifar A, Omidvar R, Hadavand N, Hassanvand M, Poopak A, Bakhshandeh H, Mazloomzadeh S, Kakavand H, Aghakouchakzadeh M, Piazza G, Krumholz H, Bikdeli B. A Multifaceted Intervention to Mitigate the Adverse Cardiovascular Effects of Air Pollution: A Feasibility Randomized Controlled Trial. Journal Of Cardiovascular Pharmacology 2025, 85: 393-403. PMID: 40100781, DOI: 10.1097/fjc.0000000000001691.Peer-Reviewed Original ResearchRandomized Controlled TrialsCardiovascular effects of air pollutionEffects of air pollutionAtherosclerotic cardiovascular diseaseFeasibility randomized controlled trialHealth-related quality of lifeControlled TrialsFeasibility of recruitmentAnxiety levelsHealth-related qualityFeasibility of enrollmentAdverse cardiovascular effects of air pollutionCitrus fruit consumptionQuality of lifeQuality of Life IndexUsual careMultifaceted interventionIntervention armLarge-scaled randomized controlled trialsAir pollutionFruit consumptionOutdoor activitiesLife IndexCardiovascular diseasePilot study
2024
How to Use Quasi-Experimental Methods in Cardiovascular Research: A Review of Current Practice
Carter A, Jayawardana S, Costa-Font J, Nasir K, Krumholz H, Mossialos E. How to Use Quasi-Experimental Methods in Cardiovascular Research: A Review of Current Practice. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010078. PMID: 38362765, DOI: 10.1161/circoutcomes.123.010078.Peer-Reviewed Original ResearchConceptsRandomized Controlled TrialsDecision aidJoanna Briggs Institute checklistControlled TrialsQuasi-experimental methodObservational studyInterrupted time series analysisQuasi-experimental studyDifference-in-differences analysisEstimate causal relationshipsSystematic search strategyInstrumental variable analysisQuality appraisalInstitute checklistInclusion criteriaGraphical decision aidReview of current practicesCurrent practicesRandom assignmentSearch strategyHigh-impact articlesVariability analysisTime series analysisCardiovascular researchAIDSWhen Direct Oral Anticoagulants Should Not Be Standard Treatment JACC State-of-the-Art Review
Bejjani A, Khairani C, Assi A, Piazza G, Sadeghipour P, Talasaz A, Fanikos J, Connors J, Siegal D, Barnes G, Martin K, Angiolillo D, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind M, Ruff C, Goldhaber S, Krumholz H, Mehran R, Cushman M, Eikelboom J, Lip G, Weitz J, Lopes R, Bikdeli B. When Direct Oral Anticoagulants Should Not Be Standard Treatment JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2024, 83: 444-465. PMID: 38233019, DOI: 10.1016/j.jacc.2023.10.038.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsStandard of careRandomized Controlled TrialsOral anticoagulantsAtrial fibrillationCatheter-associated deep vein thrombosisCerebral venous sinus thrombosisControlled TrialsVitamin K antagonistsThrombotic antiphospholipid syndromeEnd-stage renal diseaseLeft ventricular thrombusVenous thromboembolism treatmentVenous sinus thrombosisDeep vein thrombosisRheumatic heart diseaseReview of randomized controlled trialsEvidence-based reviewK antagonistsAntiphospholipid syndromeSinus thrombosisVentricular thrombusVein thrombosisThromboembolism treatmentVenous thrombosis
2020
Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials.
Madhavan M, Bikdeli B, Redfors B, Biondi-Zoccai G, Varunok N, Burton J, Crowley A, Francese D, Gupta A, DER Nigoghossian C, Chatterjee S, Palmerini T, Benedetto U, You S, Ohman E, Kastrati A, Steg P, Gibson C, Angiolillo D, Krumholz H, Stone G. Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials. Minerva Cardioangiologica 2020, 69: 398-407. PMID: 33258563, DOI: 10.23736/s2724-5683.20.05353-0.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeNetwork Meta-AnalysisIncidence rate ratiosReceptor inhibitorsRandom-effects methodMeta-analysisCoronary syndromeMonths of follow-up timePatients of advanced ageControlled TrialsBackground of aspirinEfficacy of prasugrelST-elevation myocardial infarctionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsFollow-up timeFrequentist network meta-analysisManagement of patientsRegister of Controlled TrialsShort-term outcomesLong-term outcomesCochrane Central RegisterRandomized Controlled TrialsHemorrhagic outcomesAntiplatelet strategies
2006
Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease
Coca SG, Krumholz HM, Garg AX, Parikh CR. Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease. JAMA 2006, 296: 1377-1384. PMID: 16985230, DOI: 10.1001/jama.296.11.1377.Peer-Reviewed Original ResearchConceptsChronic congestive heart failureCongestive heart failureRenal diseaseRenal functionHeart failureSubgroup analysisCardiovascular diseaseCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAldosterone system antagonistsBaseline renal functionHeart Association guidelinesCardiovascular disease trialsCurrent American CollegeRandomized Controlled TrialsAcute myocardial infarctionEffects of interventionsRepresentation of patientsOriginal articlesBaseline characteristicsCardiovascular mortalityPatient characteristicsControlled TrialsPrognostic featuresMyocardial infarction
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply