2025
Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy
Oikonomou E, Sangha V, Vasisht Shankar S, Coppi A, Krumholz H, Nasir K, Miller E, Gallegos Kattan C, Al-Mallah M, Al-Kindi S, Khera R. Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. European Heart Journal 2025, ehaf450. PMID: 40679604, DOI: 10.1093/eurheartj/ehaf450.Peer-Reviewed Original ResearchTransthyretin amyloid cardiomyopathyTransthoracic echocardiographyATTR-CMAmyloid cardiomyopathyPreclinical progressAI-ECGRetrospective analysisDiagnosis of transthyretin amyloid cardiomyopathyDeep learning modelsAge/sex matched controlsRetrospective analysis of individualsLearning modelsPreclinical testingElectrocardiography imagingEchocardiographyHouston Methodist HospitalYale New Haven Health SystemAdvanced imagingElectrocardiographyPreclinical coursesCardiomyopathyPreclinical stage
1997
Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography.
Goldberg DJ, Radford MJ, Krumholz HM. Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography. Connecticut Medicine 1997, 61: 143-5. PMID: 9097485.Peer-Reviewed Original ResearchConceptsMyocardial infarctionEjection fractionLeft ventricular ejection fractionVentricular ejection fractionVentricular systolic functionAcute myocardial infarctionCare of patientsSystolic functionVentricular functionEchocardiography studyMedicare beneficiariesInfarctionEchocardiographyReportPrincipal findings
1996
Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen N, Jaffe C, Krumholz H, Johnson K, Lynch P, Natale D, Atkinson P, Demon P, Wackers F. Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions. The American Journal Of Cardiology 1996, 77: 843-850. PMID: 8623737, DOI: 10.1016/s0002-9149(97)89179-5.Peer-Reviewed Original ResearchConceptsEquilibrium radionuclide angiographyVentricular ejection fractionEjection fractionRadionuclide angiographyEchocardiographic LVEFEquilibrium radionuclideRadionuclide LVEFClinical relevanceLeft ventricular ejection fractionCorrelation of LVEFDetermination of LVEFPatient management decisionsPotential clinical relevanceRelevant differencesInter-observer reproducibilityStable patientsLV functionLimits of agreementLVEFIndividual patientsRepeat assessmentEchocardiographyAngiographyBlinded analysisRepeat analysis
1994
Clinical utility of transthoracic two-dimensional and Doppler echocardiography
Krumholz H, Douglas P, Goldman L, Waksmonski C. Clinical utility of transthoracic two-dimensional and Doppler echocardiography. Journal Of The American College Of Cardiology 1994, 24: 125-131. PMID: 8006255, DOI: 10.1016/0735-1097(94)90552-5.Peer-Reviewed Original ResearchConceptsNew diagnosisChart reviewEchocardiographic examinationMitral regurgitationClinical utilityLeft ventricular wall motion abnormalitiesTertiary care teaching hospitalVentricular wall motion abnormalitiesGreater mitral regurgitationProspective observational studyUse of echocardiographyWall motion abnormalitiesPharmacologic treatmentTransthoracic twoDoppler echocardiographyMotion abnormalitiesPhysician interviewsTeaching hospitalObservational studyEchocardiographyClinical practiceOutpatientsInpatientsPatient diagnosisContemporary echocardiography
1993
Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi
Manning W, Silverman D, Gordon S, Krumholz H, Douglas P. Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi. New England Journal Of Medicine 1993, 328: 750-755. PMID: 8437595, DOI: 10.1056/nejm199303183281102.Peer-Reviewed Original ResearchConceptsAtrial thrombusLong-term anticoagulationAtrial fibrillationTransesophageal echocardiographyOral anticoagulationEarly cardioversionTransthoracic echocardiographyLong-term oral anticoagulationConventional noninvasive techniquesOral anticoagulation therapyShort-term anticoagulationPresence of thrombusAnticoagulation therapyEmbolic eventsQualifying patientsConsecutive patientsProlonged anticoagulationSuccessful cardioversionSinus rhythmAnticoagulationCardioversionEchocardiographyPatientsThrombusFibrillation
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