2025
Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials
Ortega-Paz L, Talasaz A, Sadeghipour P, Rashedi S, Connors J, Angiolillo D, Cavallari L, Jimenez D, Bastidas G, Lorenzi E, Berry L, Hills T, McAuley D, Shah T, Lansky A, Deepti S, Gaitán-Duarte H, Potpara T, Galli M, Dixon D, Piazza G, Lip G, Mehran R, Libby P, Krumholz H, Bikdeli B. Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials. Thrombosis Research 2025, 255: 109484. PMID: 40992230, DOI: 10.1016/j.thromres.2025.109484.Peer-Reviewed Original ResearchRandomized Controlled TrialsStatin therapyCollaborative meta-analysisHospitalized patientsClinical impactImpact of statin therapyMeta-analysis of randomized controlled trialsCo-treatmentLiver enzyme abnormalitiesExcellent safety profileEffects of statinsCOVID-19 patientsNo significant differenceSafety profileEnzyme abnormalitiesLiver enzymesStatinsSafety outcomesTherapyPatientsCOVID-19 outcomesDisease severitySignificant differenceRandomized participantsSystematic review
2021
Association of COVID-19 Hospitalization Volume and Case Growth at US Hospitals with Patient Outcomes
Khera R, Liu Y, de Lemos JA, Das SR, Pandey A, Omar W, Kumbhani DJ, Girotra S, Yeh RW, Rutan C, Walchok J, Lin Z, Bradley SM, Velazquez EJ, Churchwell KB, Nallamothu BK, Krumholz HM, Curtis JP. Association of COVID-19 Hospitalization Volume and Case Growth at US Hospitals with Patient Outcomes. The American Journal Of Medicine 2021, 134: 1380-1388.e3. PMID: 34343515, PMCID: PMC8325555, DOI: 10.1016/j.amjmed.2021.06.034.Peer-Reviewed Original ResearchConceptsCOVID-19 hospitalizationHospitalization volumeAmerican Heart Association COVID-19 Cardiovascular Disease RegistryCase volumeUS hospitalsCoronavirus disease 2019 (COVID-19) hospitalizationIntensive care unit therapyHospital case fatality ratePoor COVID-19 outcomesCardiovascular Disease RegistryHospital case volumeCase fatality rateCOVID-19 outcomesHospital bed capacityLowest quartilePatient outcomesHospital careHigher oddsTriage strategiesFuture health challengesDisease RegistryMedical treatmentEarly identificationHospitalSignificant association
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