2025
Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials
Ortega-Paz L, Talasaz A, Sadeghipour P, Rashedi S, Connors J, Angiolillo D, Cavallari L, Jimenez D, Bastidas G, Lorenzi E, Berry L, Hills T, McAuley D, Shah T, Lansky A, Deepti S, Gaitán-Duarte H, Potpara T, Galli M, Dixon D, Piazza G, Lip G, Mehran R, Libby P, Krumholz H, Bikdeli B. Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials. Thrombosis Research 2025, 255: 109484. PMID: 40992230, DOI: 10.1016/j.thromres.2025.109484.Peer-Reviewed Original ResearchRandomized Controlled TrialsStatin therapyCollaborative meta-analysisHospitalized patientsClinical impactImpact of statin therapyMeta-analysis of randomized controlled trialsCo-treatmentLiver enzyme abnormalitiesExcellent safety profileEffects of statinsCOVID-19 patientsNo significant differenceSafety profileEnzyme abnormalitiesLiver enzymesStatinsSafety outcomesTherapyPatientsCOVID-19 outcomesDisease severitySignificant differenceRandomized participantsSystematic reviewApproach to the Postmarket Evaluation of Consumer Wearable Technologies
Pundi K, Bhavnani S, Seninger C, Zuckerman B, Paulsen J, Aguel F, Din N, Viggiano B, Yoo R, Dalal N, Go A, Granger C, Krumholz H, Lacar K, Li R, Lin S, Mahaffey K, Mahoney M, McCall D, Hills M, Harrington R, Hernandez-Boussard T, Saha A, Shah N, Turakhia M. Approach to the Postmarket Evaluation of Consumer Wearable Technologies. JAMA Cardiology 2025, 10 PMID: 40928810, DOI: 10.1001/jamacardio.2025.3006.Peer-Reviewed Original ResearchWearable technologyConsumer wearablesConsumer wearable technologyPostmarketing evaluationReal-world dataHealth care delivery systemPatient-centered innovationCare delivery systemHealth monitoringHealth care systemHealth care resourcesAuthorization processCross-platform dataWearablePatient harmCare systemGuideline-directed treatmentCare resourcesDigital healthMedical careData qualityData completenessPostmarketing researchHealthClinical questionsMoving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care
Jain S, Mortazavi B, Chan You S, Yao X, Lam C, Elias P, Poterucha T, Avram R, Tison G, Pirruccello J, Huang C, Wiens J, Schwamm L, Ruan X, Dunn J, Luo Y, Spatz E, Krumholz H. Moving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care. Journal Of The American College Of Cardiology 2025, 86: 691-695. PMID: 40903130, DOI: 10.1016/j.jacc.2025.07.040.Peer-Reviewed Original ResearchA Tad Bit of Extra Clarity About Clots: Why JACC Took Interest in TADCLOT
Bikdeli B, Cohen D, Bittl J, Krumholz H. A Tad Bit of Extra Clarity About Clots: Why JACC Took Interest in TADCLOT. Journal Of The American College Of Cardiology 2025 PMID: 40892618, DOI: 10.1016/j.jacc.2025.08.049.Peer-Reviewed Original ResearchHow PARTHENOPE Charts the Course Toward Precision DAPT: Navigating Future Science in Antiplatelet Therapy
You S, Bikdeli B, Lin Z, Bittl J, Cohen D, Krumholz H. How PARTHENOPE Charts the Course Toward Precision DAPT: Navigating Future Science in Antiplatelet Therapy. Journal Of The American College Of Cardiology 2025 PMID: 40892615, DOI: 10.1016/j.jacc.2025.08.045.Peer-Reviewed Original ResearchCharacterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.Peer-Reviewed Original ResearchSelf-reported diagnosisPostural orthostatic tachycardia syndromeHealth statusSelf-reported long COVIDOrthostatic tachycardia syndromeHealth status of peopleEuroQol visual analog scaleDiagnosis of postural orthostatic tachycardia syndromeOnline observational studyExperiences of peopleStatus of peoplePostacute COVID-19 syndromeChest painVisual analog scaleHigher RatesExcessive fatigueHealth burdenMyalgic encephalomyelitis/chronic fatigue syndromeSocial isolationInternal tremorExercise intoleranceObservational studyFinancial difficultiesAnalog scaleSuicidal thoughtsAll-cause excess mortality associated with the Lāhainā, Maui fires
Nakatsuka M, Taparra K, Renton B, Chen A, Chen J, Krumholz H, Faust J. All-cause excess mortality associated with the Lāhainā, Maui fires. Frontiers In Climate 2025, 7: 1611198. DOI: 10.3389/fclim.2025.1611198.Peer-Reviewed Original ResearchAssociation between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure
Jimenez J, Zhang L, Lin Z, Ferrante L, Falvey J, Walkey A, Krumholz H, Jain S. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure. CHEST Journal 2025 PMID: 40818773, DOI: 10.1016/j.chest.2025.07.4079.Peer-Reviewed Original ResearchSafety-net hospitalMedian odds ratioSafety-net hospital statusDelivery of rehabilitationOlder adultsRehabilitation deliveryNon-SNHsIntensive care unitSocioeconomic disadvantageRetrospective cohort studyCohort study of older adultsHospital safety-net statusDisproportionate share hospital indexRetrospective cohort study of older adultsHierarchical multivariable logistic regression modelsStudy of older adultsSafety-net statusMedicare Provider AnalysisMultivariate logistic regression modelCritical illnessLogistic regression modelsRehabilitation servicesSocioeconomic disparitiesHospital characteristicsUS hospitalsEmicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis
Glaeser-Khan S, Ito S, Sra M, Richmond R, Bona R, Krumholz H, Croteau S, Cuker A, Goshua G. Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis. Blood Advances 2025 PMID: 40795232, DOI: 10.1182/bloodadvances.2025016822.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioSevere hemophilia AIntracranial hemorrhageEmicizumab prophylaxisHemophilia ASevere HAWTP thresholdStandard careProphylactic factor replacementUS societal perspectiveInfants Aged 0Markov cohort modelLifetime time horizonCost-effectiveness ratioProbabilistic sensitivity analysesFVIII inhibitorsBleeding riskFactor replacementSevere complicationsEmicizumabAccess placementCentral venous access placementPrimary outcomeProphylaxisNeurological disabilityCharacterization of Research Grant Terminations at the National Institutes of Health
Liu M, Kadakia K, Patel V, Krumholz H. Characterization of Research Grant Terminations at the National Institutes of Health. JAMA 2025, 334: 534-536. PMID: 40338733, PMCID: PMC12062975, DOI: 10.1001/jama.2025.7707.Peer-Reviewed Original ResearchA Breakthrough With a Burden Access, Affordability, and the Future of ATTR-CM Therapy
Krumholz H, Kittleson M, Kadakia K. A Breakthrough With a Burden Access, Affordability, and the Future of ATTR-CM Therapy. Journal Of The American College Of Cardiology 2025, 86: 409-411. PMID: 40769668, DOI: 10.1016/j.jacc.2025.07.001.Peer-Reviewed Original ResearchThe Role of Clinicians in Advancing Cardiovascular Device Safety
Kadakia K, Dhruva S, Krumholz H. The Role of Clinicians in Advancing Cardiovascular Device Safety. Journal Of The American College Of Cardiology 2025, 86: 481-484. PMID: 40803782, DOI: 10.1016/j.jacc.2025.05.015.Peer-Reviewed Original ResearchFirearm Laws and Pediatric Mortality in the US
Faust J, Chen J, Bhat S, Otugo O, Yaver M, Renton B, Chen A, Lin Z, Krumholz H. Firearm Laws and Pediatric Mortality in the US. JAMA Pediatrics 2025, 179: 896-902. PMID: 40489107, PMCID: PMC12150223, DOI: 10.1001/jamapediatrics.2025.1363.Peer-Reviewed Original ResearchUS Supreme Court decisionSupreme Court decisionPediatric firearm mortalityCourt decisionsFirearm deathsFirearm mortalityLegal landscapeLaw categoriesLaw groupFirearm lawsFirearm regulationsLegal actionWide-ranging Online DataFirearmExcess mortalityUS children aged 0Centers for Disease Control and Prevention Wide-ranging Online DataUS Centers for Disease Control and Prevention Wide-ranging ONline DataNon-Hispanic black populationUS statesLawMortality incidence ratesChildren Aged 0Associated with excess mortalityOnline dataChanges in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush J, Krumholz H, Abaluck J. Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. JAMA Network Open 2025, 8: e2526013. PMID: 40779264, PMCID: PMC12334959, DOI: 10.1001/jamanetworkopen.2025.26013.Peer-Reviewed Original ResearchConceptsHealth care expendituresCardiovascular risk factorsCare expendituresCohort studyRisk factorsYale New Haven Health SystemCohort study of adultsType 2 diabetes statusLong-term impactStudy of adultsHealth systemRetrospective cohort studyBlood pressureHemoglobin A1c reductionMain OutcomesTotal cholesterolSentara HealthcareInpatient staySecondary outcomesGlucagon-like peptide-1 receptor agonistsPrimary outcomeHealthPeptide-1 receptor agonistsAssociated with clinical outcomesAssociated with reductionsFDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program
Kadakia K, Dhruva S, Ross J, Burke J, Johnston J, Ramachandran R, Krumholz H, Rathi V. FDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program. JAMA Internal Medicine 2025, 185: 996-1004. PMID: 40587167, PMCID: PMC12210143, DOI: 10.1001/jamainternmed.2025.2235.Peer-Reviewed Original ResearchConceptsFood and Drug AdministrationFDA review timesFood and Drug Administration authorityFood and Drug Administration dataShort follow-up durationUS Food and Drug AdministrationFollow-up durationDevice programmingEffectiveness end pointCross-sectional studyHigh-risk devicesSurrogate measureTarget timeframePostmarketing studiesMain OutcomesEnd pointsPatient accessDrug AdministrationHigh riskClass IStudy characteristicsTherapeutic devicesClinical testingSurrogate measures of effectivenessMeasures of effectivenessCoronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes
Dong W, Lu Y, Li S, Sawano M, Caraballo C, Liu Y, Khera A, Philippakis A, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Herrington D, Post W, Rich S, Rotter J, Krumholz H. Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes. JACC Advances 2025, 4: 101994. PMID: 40712269, PMCID: PMC12311502, DOI: 10.1016/j.jacadv.2025.101994.Peer-Reviewed Original ResearchAcute myocardial infarction subtypePolygenic risk scoresAcute myocardial infarctionRisk of acute myocardial infarctionRisk scoreCoronary artery diseaseAssociated with acute myocardial infarctionEstimated riskAssociated with higher riskAssociated with MIAcute myocardial infarction patientsMultinomial logistic regressionArtery diseaseNonobstructive coronary artery diseaseLogistic regressionFemale-to-male ratioYoung adultsCox regressionHigh riskInfarction subtypesYoung individualsMyocardial infarctionEarly-onsetScoresSexComparing Claims Data to Stroke and Bleeding in the NCDR Left Atrial Appendage Occlusion Registry
Faridi K, Freeman J, Wang Y, Pereira L, Zimmerman S, Friedman D, Sharma R, Higgins A, Mortazavi B, Ross J, Krumholz H, Yeh R, Curtis J. Comparing Claims Data to Stroke and Bleeding in the NCDR Left Atrial Appendage Occlusion Registry. JACC Advances 2025, 4: 102019. PMID: 40712270, PMCID: PMC12311505, DOI: 10.1016/j.jacadv.2025.102019.Peer-Reviewed Original ResearchInternational ClassificationPositive predictive valueClaims dataRegistry dataIncidence rateNational Cardiovascular Data Registry LAAO RegistryGastrointestinal bleedingIntracranial hemorrhageHemorrhagic strokeBleeding eventsIschemic strokePostmarketing surveillanceTranscatheter left atrial appendage occlusionInpatient hospitalizationSurveillance of therapyRevision codesMajor bleeding eventsNegative predictive valueKappa statisticRegistryRegistry patientsModerate agreementEstimates of sensitivityMajor bleedingAppendage occlusionIdentification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning
Sangha V, Dhingra L, Aminorroaya A, Croon P, Sikand N, Sen S, Martinez M, Maron M, Krumholz H, Asselbergs F, Oikonomou E, Khera R. Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning. Nature Cardiovascular Research 2025, 4: 991-1000. PMID: 40696040, DOI: 10.1038/s44161-025-00685-3.Peer-Reviewed Original ResearchHypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Hypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic. Journal Of Clinical Hypertension 2025, 27: e70093. PMID: 40685707, PMCID: PMC12277530, DOI: 10.1111/jch.70093.Peer-Reviewed Original ResearchConceptsHypertension prevalencePrevalence ratiosUS adultsAge-standardized prevalence estimatesAggressive public health effortsPublic health effortsPre-pandemicControl of hypertensionCOVID-19 pandemicHypertension awarenessHealth effortsPoisson regressionImpact of hypertensionPost-pandemicPrevalence estimatesNHANES dataNationwide prevalenceCause of deathUnited StatesBlood pressure controlNational trendsPrevalenceCOVID-19AdultsHypertensionArtificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy
Oikonomou E, Sangha V, Vasisht Shankar S, Coppi A, Krumholz H, Nasir K, Miller E, Gallegos Kattan C, Al-Mallah M, Al-Kindi S, Khera R. Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. European Heart Journal 2025, ehaf450. PMID: 40679604, DOI: 10.1093/eurheartj/ehaf450.Peer-Reviewed Original ResearchTransthyretin amyloid cardiomyopathyTransthoracic echocardiographyATTR-CMAmyloid cardiomyopathyPreclinical progressAI-ECGRetrospective analysisDiagnosis of transthyretin amyloid cardiomyopathyDeep learning modelsAge/sex matched controlsRetrospective analysis of individualsLearning modelsPreclinical testingElectrocardiography imagingEchocardiographyHouston Methodist HospitalYale New Haven Health SystemAdvanced imagingElectrocardiographyPreclinical coursesCardiomyopathyPreclinical stage
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